ArticleInternational journal of obesity (2005)2019
Gut hormone release after gastric bypass depends on the length of the biliopancreatic limb.
Article in International journal of obesity (2005), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 37 citations in OpenAlex.
- Effect of RYGB Limb Lengths on HbA1c in Patients with Obesity and Type 2 Diabetes.Obesity surgery · 2026Trial
- Glucose-Dependent Insulinotropic Polypeptide and Glucagon After Weight Loss Induced by Diet or Bariatric Surgery.Obesity (Silver Spring, Md.) · 2025Trial
- The Effect of Standard Versus Longer Intestinal Bypass on GLP-1 Regulation and Glucose Metabolism in Patients With Type 2 Diabetes Undergoing Roux-en-Y Gastric Bypass: The Long-Limb Study.Diabetes care · 2021 · on this mapTrial
- Efficacy and safety of limb distalization after Roux-en-Y gastric bypass: a retrospective cohort study.Frontiers in surgery · 2026Article
- Gut microbiota alterations induced by Roux-en-Y gastric bypass result in glucose-lowering by enhancing intestinal glucose excretion.Gut microbes · 2025Article
- Methodological Concerns in Long Versus Short BPL RYGB Following Sleeve Gastrectomy: A Comment on Salman et al.Obesity surgery · 2025Article
- Glycemic variability and entero-pancreatic hormones signatures after different bariatric surgery procedures: a cross-sectional study.International journal of obesity (2005) · 2025Article
- Mid-term Outcomes in Primary Roux-en-Y Gastric Bypass Procedures with Short or Long Biliopancreatic Limb.Obesity surgery · 2025Article
- The Impact of Cholecystectomy in Patients with Post-Bariatric Surgery Hypoglycemia.Obesity surgery · 2024Article
- Individuals with type 2 diabetes have higher density of small intestinal neurotensin-expressing cells.Molecular and cellular biochemistry · 2023Article
- Towards precision medicine in bariatric surgery prescription.Reviews in endocrine & metabolic disorders · 2023Review
- Effects of short or long biliopancreatic limb length after laparoscopic Roux-en-Y gastric bypass surgery for obesity: a propensity score-matched analysis.Langenbeck's archives of surgery · 2022Article
- Shortening the Biliopancreatic Limb Length of One Anastomosis Gastric Bypass Maintains Glucose Homeostasis Improvement with Limited Weight Loss.Journal of clinical medicine · 2022Article
- Similar Gut Hormone Secretions Two Years After One Anastomosis Gastric Bypass and Roux-en-Y Gastric Bypass: a Pilot Study.Obesity surgery · 2022Observational
- Daily transient coating of the intestine leads to weight loss and improved glucose tolerance.Metabolism: clinical and experimental · 2022Article
- Effect of Roux-en-Y Gastric Bypass with Different Lengths of Biliopancreatic and Alimentary Limbs for Patients with Type 2 Diabetes Mellitus and a BMI < 35 kg/mObesity surgery · 2021Article
- Are the Changes in Gastrointestinal Hormone Secretion Necessary for the Success of Bariatric Surgery? A Critical Review of the Literature.Obesity surgery · 2021Review
- Biliopancreatic Limb Length of Small Intestinal Bypass in Non-obese Goto-Kakizaki (GK) Rats Correlates with Gastrointestinal Hormones, Adipokines, and Improvement in Type 2 Diabetes.Obesity surgery · 2021Article
- Can Metabolite and Hormone Profiles Provide a Rationale for Choosing Between Bariatric Procedures?Obesity surgery · 2021Article
- Does Reconstruction Type After Gastric Resection Matters for Type 2 Diabetes Improvement?Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2020Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND/
objectivesChanges in gut hormone secretion are important for the anti-diabetic effects of bariatric surgery. Roux-en-Y gastric bypass (RYGB) with extended biliopancreatic limb (BPL) length may improve the metabolic outcomes when compared to the classical procedure. The purpose of this study was to compare the gut hormone responses to a liquid mixed meal after RYGB with one of two different BPL lengths. SUBJECTS/
methodsNon-diabetic weight-stable individuals previously submitted to classical RYGB (n = 9; BPL length: 87.8 ± 20.5 cm) or long BPL RYGB (n = 11; BPL length: 200 cm) underwent a liquid mixed-meal tolerance test (MMTT). Blood was sampled at baseline and 15, 30, 45, 60, 90 and 120 min later for measurement of plasma glucose, enteropancreatic hormones and total bile acids (TBA).
resultsPlasma glucose excursion curves were similar in the two groups. The long BPL RYGB group displayed significantly higher fasting and post-prandial GLP-1 (t = 0 min, p = 0.01 and t = 45 min, p < 0.05; tAUC: 11,205 ± 3399 vs 7889 ± 1686 pmol/L × min, p = 0.02) and neurotensin (t = 0 min, p = 0.02; t = 45 min, p < 0.05 and t = 60 min, p < 0.01; tAUC: 18,392 ± 7066 vs 11,437 ± 3658 pmol/L × min, p = 0.02) levels, while responses of GIP (t = 15 min, p < 0.01), insulin and C-peptide (t = 30 min, p < 0.001) were lower as compared to classical RYGB. There were no differences in glucagon, PP, PYY and TBA between the groups.
conclusionsRYGB with a longer BPL results in a distinctive post-prandial hormone profile with augmented GLP-1 and neurotensin responses that could be beneficial for the metabolic outcomes of the surgery.
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