Evidence map›Paper›PMID 29795461›Full record

ArticleInternational journal of obesity (2005)2018

Epigallocatechin gallate targets FTO and inhibits adipogenesis in an mRNA m

Ruifan Wu, Yongxi Yao, Qin Jiang, Min Cai, Qing Liu, Yizhen Wang, Xinxia Wang

Abstract read
PubMed Publisher
In one paragraph

Article in International journal of obesity (2005), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 76 papers.

0numbers the graph read from it
0cells of the map it votes in
76citing papers in PubMed
6.8field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

76 citing papers in PubMed, 135 citations in OpenAlex.

  1. Review
  2. Review
  3. NBiomolecules · 2026
    Review
  4. MFrontiers in genetics · 2026
    Review
  5. Review
  6. The emerging role of mFrontiers in immunology · 2026
    Review
  7. Review
  8. Review
  9. Article
  10. Review
  11. Article
  12. Epigenetic Mechanisms in Osteoporosis: Exploring the Power of mJournal of cellular and molecular medicine · 2025
    Review
  13. Article
  14. RNA m6A methylation regulators in sepsis.Molecular and cellular biochemistry · 2024
    Review
  15. Review
  16. Review
  17. Review
  18. Review
  19. Insights into the role of RNA mGenes & diseases · 2024
    Review
  20. mAging and disease · 2024
    Article

16 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Ruifan WuCollege of Animal Sciences, Key Laboratory of Animal Nutrition & Feed Sciences, Ministry of Agriculture, Zhejiang Provincial Laboratory of Feed and Animal Nutrition, Zhejiang University, No. 866 Yuhangtang Road, Hangzhou, Zhejiang, 310058, China.
Yongxi YaoCollege of Animal Sciences, Key Laboratory of Animal Nutrition & Feed Sciences, Ministry of Agriculture, Zhejiang Provincial Laboratory of Feed and Animal Nutrition, Zhejiang University, No. 866 Yuhangtang Road, Hangzhou, Zhejiang, 310058, China.
Qin JiangCollege of Animal Sciences, Key Laboratory of Animal Nutrition & Feed Sciences, Ministry of Agriculture, Zhejiang Provincial Laboratory of Feed and Animal Nutrition, Zhejiang University, No. 866 Yuhangtang Road, Hangzhou, Zhejiang, 310058, China.
Min CaiCollege of Animal Sciences, Key Laboratory of Animal Nutrition & Feed Sciences, Ministry of Agriculture, Zhejiang Provincial Laboratory of Feed and Animal Nutrition, Zhejiang University, No. 866 Yuhangtang Road, Hangzhou, Zhejiang, 310058, China.
Qing LiuCollege of Animal Sciences, Key Laboratory of Animal Nutrition & Feed Sciences, Ministry of Agriculture, Zhejiang Provincial Laboratory of Feed and Animal Nutrition, Zhejiang University, No. 866 Yuhangtang Road, Hangzhou, Zhejiang, 310058, China.
Yizhen WangCollege of Animal Sciences, Key Laboratory of Animal Nutrition & Feed Sciences, Ministry of Agriculture, Zhejiang Provincial Laboratory of Feed and Animal Nutrition, Zhejiang University, No. 866 Yuhangtang Road, Hangzhou, Zhejiang, 310058, China. yzwang@zju.edu.cn.
Xinxia WangCollege of Animal Sciences, Key Laboratory of Animal Nutrition & Feed Sciences, Ministry of Agriculture, Zhejiang Provincial Laboratory of Feed and Animal Nutrition, Zhejiang University, No. 866 Yuhangtang Road, Hangzhou, Zhejiang, 310058, China. xinxiawang@zju.edu.cn.
Zhejiang University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND/

objectiveN

methodsHigh-performance liquid chromatography coupled with triple-quadrupole tandem mass spectrometry (HPLC-QqQ-MS/MS) was performed to determine the m

resultsHere we showed that EGCG inhibited adipogenesis by blocking the mitotic clonal expansion (MCE) at the early stage of adipocyte differentiation. Exposing 3T3-L1 cells to EGCG reduced the expression of fat mass and obesity-associated (FTO) protein, an m

conclusionOur findings provide mechanistic insights into how m

Indexed as

3T3-L1 CellsAdipocytesAdipogenesisAlpha-Ketoglutarate-Dependent Dioxygenase FTOAnimalsAnti-Obesity AgentsCatechinDisease Models, AnimalMiceRNA-Binding ProteinsRNA, MessengerTeaAlpha-Ketoglutarate-Dependent Dioxygenase FTOAnti-Obesity AgentsCatechinepigallocatechin gallateFTO protein, mouseRNA-Binding ProteinsRNA, MessengerTeaYTHDF2 protein, mouse

Identifiers

PMID29795461
OpenAlexW2803474766

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.