ArticleJournal of perinatology : official journal of the California Perinatal Association2018
Prediction of preterm birth with and without preeclampsia using mid-pregnancy immune and growth-related molecular factors and maternal characteristics.
Article in Journal of perinatology : official journal of the California Perinatal Association, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 20 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 3 syntheses or guidelines pooled it, 34 citations in OpenAlex.
- Association of maternal prenatal copper concentration with gestational duration and preterm birth: a multicountry meta-analysis.The American journal of clinical nutrition · 2024Pooled it
- Is there a maternal blood biomarker that can predict spontaneous preterm birth prior to labour onset? A systematic review.PloS one · 2022Pooled it
- Association of maternal prenatal selenium concentration and preterm birth: a multicountry meta-analysis.BMJ global health · 2021Pooled it
- "Actionable" risk for preterm birth: patterns and prediction in California singleton births 2016-2020.BMC pregnancy and childbirth · 2026Article
- Diagnostic applicability of the circulating growth factors in preeclampsia.Scientific reports · 2025Article
- The single-cell immune profile throughout gestation and its potential value for identifying women at risk for spontaneous preterm birth.European journal of obstetrics & gynecology and reproductive biology: X · 2025Review
- Predicting Spontaneous Preterm Birth Using the Immunome.Clinics in perinatology · 2024Review
- Prediction of preterm birth at St. Mary's Hospital Lacor, Northern Uganda: a prospective cohort study.African health sciences · 2024Article
- Review
- Maternal cytokine profiles in second and early third trimester are not predictive of preterm birth.PloS one · 2024Article
- Assessing for prenatal risk factors associated with infant neurologic morbidity using a multivariate analysis.Journal of perinatology : official journal of the California Perinatal Association · 2023Article
- Decreased Adiponectin Levels in Early Pregnancy Are Associated with High Risk of Prematurity for African American Women.Journal of clinical medicine · 2022Article
- Association of Maternal Immune Activation during Pregnancy and Neurologic Outcomes in Offspring.The Journal of pediatrics · 2021Article
- Data-Driven Modeling of Pregnancy-Related Complications.Trends in molecular medicine · 2021Review
- Prediction of neonatal morbidity and very preterm delivery using maternal steroid biomarkers in early gestation.PloS one · 2021Article
- Maternal cardiovascular disease risk factors as predictors of preterm birth in California: a case-control study.BMJ open · 2020Article
- Alterations in endogenous progesterone metabolism associated with spontaneous very preterm delivery.Human reproduction open · 2020Article
- Effects of Selective Exclusion of Patients on Preterm Birth Test Performance.Obstetrics and gynecology · 2019Article
- The Association of Polymorphisms in Circadian Clock and Lipid Metabolism Genes With 2Frontiers in genetics · 2019Article
- Knowledge Gaps and Emerging Research Areas in Intrauterine Growth Restriction-Associated Brain Injury.Frontiers in endocrinology · 2019Review
Corrections and comments
- Erratum issued
Authors and funding
10 authors at 3 institutions in 1 country.
Funding
Abstract
objectiveTo evaluate if mid-pregnancy immune and growth-related molecular factors predict preterm birth (PTB) with and without (±) preeclampsia. STUDY
designIncluded were 400 women with singleton deliveries in California in 2009-2010 (200 PTB and 200 term) divided into training and testing samples at a 2:1 ratio. Sixty-three markers were tested in 15-20 serum samples using multiplex technology. Linear discriminate analysis was used to create a discriminate function. Model performance was assessed using area under the receiver operating characteristic curve (AUC).
resultsTwenty-five serum biomarkers along with maternal age <34 years and poverty status identified >80% of women with PTB ± preeclampsia with best performance in women with preterm preeclampsia (AUC = 0.889, 95% confidence interval (0.822-0.959) training; 0.883 (0.804-0.963) testing).
conclusionTogether with maternal age and poverty status, mid-pregnancy immune and growth factors reliably identified most women who went on to have a PTB ± preeclampsia.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.