ArticleNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2018
Cerebral white matter sex dimorphism in alcoholism: a diffusion tensor imaging study.
Article in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 41 citations in OpenAlex.
- A coordinate-based meta-analysis of white matter alterations in patients with alcohol use disorder.Translational psychiatry · 2022Pooled it
- Alcohol Cues Elicit Differences in Brain Activation Patterns of Abstinent Men and Women with Alcohol Use Disorders.Neuropsychiatric disease and treatment · 2026Article
- Connectomics modeling of regional networks of white-matter fractional anisotropy to predict the severity of young adult drinking.Quantitative imaging in medicine and surgery · 2025Article
- Sex-based Influences on White Matter Tract Integrity in Alcohol Use Disorder: a Systematic Review.Current addiction reports · 2025Article
- Sex and sobriety: Human brain structure and function in AUD abstinence.Alcohol (Fayetteville, N.Y.) · 2024Review
- Imaging neuroinflammation in individuals with substance use disorders.The Journal of clinical investigation · 2024Review
- Novel insight into the lipid network of plasma extracellular vesicles reveal sex-based differences in the lipidomic profile of alcohol use disorder patients.Biology of sex differences · 2024Article
- Anterior cingulate metabolite levels, memory, and inhibitory control in abstinent men and women with alcohol use disorder.Alcohol and alcoholism (Oxford, Oxfordshire) · 2023Article
- Intrinsic brain functional connectivity patterns in alcohol use disorder.Brain communications · 2022Article
- Sex is a defining feature of neuroimaging phenotypes in major brain disorders.Human brain mapping · 2022Review
- Evaluating effects of sex and age on white matter microstructural alterations in alcohol use disorder: A diffusion tensor imaging study.Alcoholism, clinical and experimental research · 2021Article
- Sex/gender differences in brain function and structure in alcohol use: A narrative review of neuroimaging findings over the last 10 years.Journal of neuroscience research · 2021Review
- Brain responsivity to emotional faces differs in men and women with and without a history of alcohol use disorder.PloS one · 2021Article
- Sex Differences in Substance Use Disorders: A Neurobiological Perspective.Frontiers in global women's health · 2021Review
- Hippocampal subfield volumes in abstinent men and women with a history of alcohol use disorder.PloS one · 2020Article
- Sex differences in associations of socioemotional dispositions measured in childhood and adolescence with brain white matter microstructure 12 years later.Personality neuroscience · 2020Article
- Alcohol's Unique Effects on Cognition in Women: A 2020 (Re)view to Envision Future Research and Treatment.Alcohol research : current reviews · 2020Review
- Role of Patient Sex in Early Recovery from Alcohol-Related Cognitive Impairment: Women Penalized.Journal of clinical medicine · 2019Article
- Article
- Selective micro-structural integrity impairment of the isthmus subregion of the corpus callosum in alcohol-dependent males.BMC psychiatry · 2019Article
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
Excessive alcohol consumption is associated with brain aberrations, including abnormalities in frontal and limbic brain regions. In a prior diffusion tensor magnetic resonance imaging (dMRI) study of neuronal circuitry connecting the frontal lobes and limbic system structures, we demonstrated decreases in white matter fractional anisotropy in abstinent alcoholic men. In the present study, we examined sex differences in alcoholism-related abnormalities of white matter connectivity and their association with alcoholism history. The dMRI scans were acquired from 49 abstinent alcoholic individuals (26 women) and 41 nonalcoholic controls (22 women). Tract-based spatial statistical tools were used to estimate regional FA of white matter tracts and to determine sex differences and their relation to measures of alcoholism history. Sex-related differences in white matter connectivity were observed in association with alcoholism: Compared to nonalcoholic men, alcoholic men had diminished FA in portions of the corpus callosum, the superior longitudinal fasciculi II and III, and the arcuate fasciculus and extreme capsule. In contrast, alcoholic women had higher FA in these regions. Sex differences also were observed for correlations between corpus callosum FA and length of sobriety. Our results suggest that sexual dimorphism in white matter microstructure in abstinent alcoholics may implicate underlying differences in the neurobehavioral liabilities for developing alcohol abuse disorders, or for sequelae following abuse.
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Registered trials
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