Evidence map›Paper›PMID 29795391›Full record

ArticleScientific reports2018

Salvianolic acids from antithrombotic Traditional Chinese Medicine Danshen are antagonists of human P2Y

Xuyang Liu, Zhan-Guo Gao, Yiran Wu, Raymond C Stevens, Kenneth A Jacobson, Suwen Zhao

Erratum issuedOpen access · goldAbstract read
In one paragraph

Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
5.1field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 34 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Salvianolic acid B inhibits thrombosis and directly blocks the thrombin catalytic site.Research and practice in thrombosis and haemostasis · 2024
    Article
  5. Review
  6. Article
  7. Effects ofFrontiers in cell and developmental biology · 2023
    Review
  8. The Potential Role of Phenolic Acids fromInternational journal of molecular sciences · 2022
    Article
  9. Article
  10. Review
  11. Review
  12. Article
  13. Update of P2Y receptor pharmacology: IUPHAR Review 27.British journal of pharmacology · 2020
    Review
  14. Article
  15. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Xuyang LiuiHuman Institute, ShanghaiTech University, Shanghai, 201210, China.
Zhan-Guo GaoMolecular Recognition Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, 20892, USA.
Yiran WuiHuman Institute, ShanghaiTech University, Shanghai, 201210, China.
Raymond C StevensiHuman Institute, ShanghaiTech University, Shanghai, 201210, China.ORCID 0000-0002-4522-8725
Kenneth A JacobsonMolecular Recognition Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, 20892, USA.ORCID 0000-0001-8104-1493
Suwen ZhaoiHuman Institute, ShanghaiTech University, Shanghai, 201210, China. zhaosw@shanghaitech.edu.cn.ORCID 0000-0001-5609-434X
ShanghaiTech University · CNNational Institutes of Health · US

Funding

Development Of P2Y Receptor LigandsZIADK031116 · NIDDK · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · PI JACOBSON, KENNETH ALAN · 2009 to 2025
$8.9M
Intramural NIH HHS ZIA DK031116
6 · The paper itself

Abstract

Many hemorheologic Traditional Chinese Medicines (TCMs) that are widely-used clinically lack molecular mechanisms of action. We hypothesized that some of the active components of hemorheologic TCMs may function through targeting prothrombotic P2Y

Indexed as

Purinergic P2Y Receptor AntagonistsAlkenesBenzofuransCaffeic AcidsDepsidesDrugs, Chinese HerbalFibrinolytic AgentsHumansLactatesMedicine, Chinese TraditionalModels, MolecularMolecular Docking SimulationMolecular StructurePolyphenolsReceptors, Purinergic P2Y1Receptors, Purinergic P2Y12AlkenesBenzofuransCaffeic Acidsdan-shen root extractDepsidesDrugs, Chinese HerbalFibrinolytic AgentsLactatesPolyphenolsPurinergic P2Y Receptor AntagonistsReceptors, Purinergic P2Y1Receptors, Purinergic P2Y12salvianolic acidsalvianolic acid Asalvianolic acid B

Identifiers

PMID29795391
PMCPMC5967328
OpenAlexW2804157395

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.