Evidence map›Paper›PMID 29795347›Full record

ArticleNature2018

Insights into catalysis and function of phosphoribosyl-linked serine ubiquitination.

Sissy Kalayil, Sagar Bhogaraju, Florian Bonn, Donghyuk Shin, Yaobin Liu, Ninghai Gan, Jérôme Basquin, Paolo Grumati, Zhao-Qing Luo, Ivan Dikic

Abstract read
In one paragraph

Article in Nature, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 72 papers.

0numbers the graph read from it
0cells of the map it votes in
72citing papers in PubMed
9.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

72 citing papers in PubMed, 115 citations in OpenAlex.

  1. Review
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12 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Sissy KalayilInstitute of Biochemistry II, Goethe University Frankfurt - Medical Faculty, University Hospital, Frankfurt am Main, Germany.
Sagar BhogarajuInstitute of Biochemistry II, Goethe University Frankfurt - Medical Faculty, University Hospital, Frankfurt am Main, Germany.
Florian BonnInstitute of Biochemistry II, Goethe University Frankfurt - Medical Faculty, University Hospital, Frankfurt am Main, Germany.
Donghyuk ShinInstitute of Biochemistry II, Goethe University Frankfurt - Medical Faculty, University Hospital, Frankfurt am Main, Germany.
Yaobin LiuInstitute of Biochemistry II, Goethe University Frankfurt - Medical Faculty, University Hospital, Frankfurt am Main, Germany.
Ninghai GanPurdue Institute of Immunology, Inflammation and Infectious Diseases and Department of Biological Sciences, Purdue University, West Lafayette, IN, USA.
Jérôme BasquinMax Planck Institute of Biochemistry, Department of Structural Cell Biology, Martinsried, Germany.
Paolo GrumatiInstitute of Biochemistry II, Goethe University Frankfurt - Medical Faculty, University Hospital, Frankfurt am Main, Germany.
Zhao-Qing LuoPurdue Institute of Immunology, Inflammation and Infectious Diseases and Department of Biological Sciences, Purdue University, West Lafayette, IN, USA.
Ivan DikicInstitute of Biochemistry II, Goethe University Frankfurt - Medical Faculty, University Hospital, Frankfurt am Main, Germany. ivan.dikic@biochem2.de.
Goethe University Frankfurt · DEPurdue University West Lafayette · USUniversity Hospital Frankfurt · DEMax Planck Institute of Biochemistry · DE

Funding

Effector-mediated Ubiquitin Manipulation in Legionella Pneumophila PathogenesisR01AI127465 · NIAID · PURDUE UNIVERSITY · PI Qing Deng · 2017 to 2026
$3.4M
NIAID NIH HHS R01 AI127465
6 · The paper itself

Abstract

Conventional ubiquitination regulates key cellular processes by catalysing the ATP-dependent formation of an isopeptide bond between ubiquitin (Ub) and primary amines in substrate proteins

Indexed as

BiocatalysisUbiquitinationAdenosine DiphosphateADP Ribose TransferasesAmino Acid SequenceBacterial ProteinsBinding SitesCatalytic DomainCrystallography, X-RayLegionella pneumophilaLegionnaires' DiseaseMembrane ProteinsModels, MolecularPhosphoric Diester HydrolasesProtein Structure, SecondarySerineAdenosine DiphosphateADP Ribose TransferasesBacterial ProteinsMembrane ProteinsPhosphoric Diester HydrolasesSdeA protein, Legionella pneumophilaSerineUbiquitin

Identifiers

PMID29795347
PMCPMC5980784
OpenAlexW2803828311

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.