Evidence map›Paper›PMID 29795314›Full record

Trial reportJournal of perinatology : official journal of the California Perinatal Association2018

The window of improved neonatal respiratory compliance after rescue antenatal steroids.

Brian K Jordan, Diane Schilling, Cindy T McEvoy

Registry-linked trialAbstract readComparative StudyMulticenter StudyRandomized Controlled Trial
In one paragraph

Trial report in Journal of perinatology : official journal of the California Perinatal Association, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00669383 (Rescue Antenatal Steroids and Lung Volumes in Preterm Infants), which is not on this map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
0.4field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00669383 nacompletednot on this map

Rescue Antenatal Steroids and Lung Volumes in Preterm Infants

TypeinterventionalSponsorOregon Health and Science UniversityRan2001 to 2009Enrolled85ConditionsRespiratory Compliance, Functional Residual Capacity, Pulmonary Function TestingArmsbetamethasone, placebo
3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it, 4 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Brian K JordanDivision of Neonatology, Department of Pediatrics, Oregon Health and Science University, Portland, OR, USA. jordabr@ohsu.edu.ORCID http://orcid.org/0000-0002-1553-8503
Diane SchillingDivision of Neonatology, Department of Pediatrics, Oregon Health and Science University, Portland, OR, USA.
Cindy T McEvoyDivision of Neonatology, Department of Pediatrics, Oregon Health and Science University, Portland, OR, USA.
Oregon Health & Science University · US

Funding

Oregon Clinical and Translational Research InstituteUL1TR000128 · NCATS · OREGON HEALTH & SCIENCE UNIVERSITY · PI ELLISON, DAVID H · 2012 to 2015
$28.7M
VitC to Decrease Effects of Smoking in Pregnancy on Infant Lung Function-CCC-LeadR01HL105447 · NHLBI · OREGON HEALTH & SCIENCE UNIVERSITY · PI MCEVOY, CYNTHIA T · 2012 to 2021
$9.8M
In-Utero Smoke, Vitamin C and Newborn Lung FunctionK23HL080231 · NHLBI · OREGON HEALTH & SCIENCE UNIVERSITY · PI MCEVOY, CYNTHIA T · 2006 to 2010
$675k
NCATS NIH HHS UL1 TR000128NHLBI NIH HHS K23 HL080231NHLBI NIH HHS L40 HL133983NHLBI NIH HHS R01 HL105447
6 · The paper itself

Abstract

objectiveTo evaluate whether premature infants delivered ≤7 days after rescue antenatal steroid treatment (ideal treatment) have increased passive respiratory compliance compared to those delivered >7 days after treatment (remote treatment).

methodsSecondary analysis of a randomized trial of rescue antenatal steroids on respiratory compliance. Infants in the treatment group were stratified by the interval between rescue antenatal steroids and delivery. We then compared the respiratory compliance in the ideal vs. remote groups.

resultsForty-four women (56 infants) received rescue antenatal steroids. Forty-nine infants had evaluable respiratory compliance measurements, with 27 (GA 30.1 weeks, BW 1362 g) "ideally" treated, and 22 (GA 33.8 weeks, BW 2248 g) "remotely" treated. Respiratory compliance was significantly higher for the ideal compared to the remote group (1.32 vs. 1.06 mL/cm H

conclusionInfants treated with rescue antenatal steroids have a significantly higher respiratory compliance if delivery occurs within 7 days after treatment.

Indexed as

Infant, PrematureBetamethasoneFemaleFloridaGestational AgeHumansInfant HealthInfant, NewbornLung ComplianceOregonPregnancyPregnancy OutcomePrenatal CarePulmonary SurfactantsRespiratory Distress Syndrome, NewbornRespiratory Function TestsBetamethasonePulmonary Surfactants

Identifiers

PMID29795314
PMCPMC6070394
OpenAlexW2805020981

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.