ArticleBritish journal of cancer2018
Mendelian randomisation study of age at menarche and age at menopause and the risk of colorectal cancer.
Registry-linked trialOpen access · hybridAbstract read
In one paragraph
Article in British journal of cancer, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02328677 (ColoCare Transdisciplinary Research in Colorectal Cancer Prognosis), which is not on this map. Cited by 12 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 2 pooled it
1.1field-weighted citation impact, top 20% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
ColoCare Transdisciplinary Research in Colorectal Cancer Prognosis
Who cites it
12 citing papers in PubMed, 2 syntheses or guidelines pooled it, 20 citations in OpenAlex.
- Systematic review of Mendelian randomization studies on risk of cancer.BMC medicine · 2022Pooled it
- Female sex is associated with a lower risk of bone metastases and favourable prognosis in non-sex-specific cancers.BMC cancer · 2019Pooled it
- Age at menarche and idiopathic pulmonary fibrosis: a two-sample mendelian randomization study.BMC pulmonary medicine · 2024Article
- Age at Menarche, age at Natural Menopause, and Risk of Lung and Colorectal Cancers: A Mendelian Randomization Study.Journal of the Endocrine Society · 2023Article
- Review of mendelian randomization studies on age at natural menopause.Frontiers in endocrinology · 2023Review
- Genetic causal relationship between age at menarche and benign oesophageal neoplasia identified by a Mendelian randomization study.Frontiers in endocrinology · 2023Article
- Reproductive Factors in Relation to Incidence of Lung and Colorectal Cancers in a Cohort of Norwegian Women: The HUNT Study.Journal of the Endocrine Society · 2022Article
- Identifying potential causal effects of age at menopause: a Mendelian randomization phenome-wide association study.European journal of epidemiology · 2022Article
- Reproductive Factors and Colorectal Cancer Risk: A Population-Based Case-Control Study.JNCI cancer spectrum · 2022Article
- Genetic Variation and Mendelian Randomization Approaches.Advances in experimental medicine and biology · 2022Article
- Shared Genetics Between Age at Menopause, Early Menopause, POI and Other Traits.Frontiers in genetics · 2021Review
- Mendelian randomisation: A powerful and inexpensive method for identifying and excluding non-genetic risk factors for colorectal cancer.Molecular aspects of medicine · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
51 authors at 20 institutions in 9 countries.
Sonja NeumeyerDivision of Cancer Epidemiology, German Cancer Research Center (DKFZ), 69120, Heidelberg, Germany.
Barbara L BanburyPublic Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, 98124, USA.
Volker ArndtDivision of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), 69120, Heidelberg, Germany.
Sonja I BerndtDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, 20892-9776, USA.
Stephane BezieauCentre Hospitalier Universitaire (CHU), Nantes Service de Génétique Médicale, 44093, Nantes, France.
Stephanie A BienPublic Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, 98124, USA.
Dan D BuchananColorectal Oncogenomics Group, Genetic Epidemiology Laboratory, Department of Pathology, The University of Melbourne, Melbourne, VIC, 3010, Australia.
Katja ButterbachDivision of Cancer Epidemiology, German Cancer Research Center (DKFZ), 69120, Heidelberg, Germany.
Bette J CaanDivision of Research, Kaiser Permanente Medical Care Program of Northern California, Oakland, 94612, CA, USA.
Peter T CampbellEpidemiology Research Program, American Cancer Society, Atlanta, GA, 30329-4251, USA.
Graham CaseyCenter for Public Health Genomics, University of Virginia, Charlottesville, VA, 22908, USA.
Andrew T ChanClinical and Translational Epidemiology Unit and Division of Gastroenterology, Massachusetts General Hospital, Boston, MA, 02115, USA.
Stephen J ChanockDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, 20892-9776, USA.
James Y DaiPublic Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, 98124, USA.
Steven GallingerLunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, M5G 1 X 5, Canada.
Edward L GiovannucciChanning Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, 02115, USA.
Graham G GilesCentre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Parkville, VIC, 3010, Australia.
William M GradyDepartment of Medicine, Division of Gastroenterology, University of Washington School of Medicine, Seattle, WA, 98195, USA.
Jochen HampeMedical Department 1, University Hospital Dresden, TU Dresden, 01307, Dresden, Germany.
Michael HoffmeisterDivision of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), 69120, Heidelberg, Germany.
John L HopperCentre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Parkville, VIC, 3010, Australia.
Li HsuPublic Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, 98124, USA.
Mark A JenkinsCentre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Parkville, VIC, 3010, Australia.
Amit JoshiDepartment of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 02115, USA.
Susanna C LarssonInstitute of Environmental Medicine, Karolinska Institutet Solna, SE-171 77, Stockholm, Sweden.
Loic Le MarchandEpidemiology Program, University of Hawaii Cancer Center, Honolulu, 96822, HI, USA.
Annika LindblomDepartment of Clinical Genetics, Karolinska University Hospital Solna, SE-171 77, Stockholm, Sweden.
Victor MorenoCatalan Institute of Oncology, Bellvitge Biomedical Research Institute (IDIBELL), 08028, Barcelona, Spain.
Mathieu LemireOntario Institute for Cancer Research, Toronto, ON, M5G 0A3, Canada.
Li LiDepartment of Family Medicine and Community Health, Case Western Reserve University, Cleveland, OH, 44106, USA.
Yi LinPublic Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, 98124, USA.
Kenneth OffitDepartment of Medicine, Clinical Genetics Service, Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA.
Polly A NewcombPublic Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, 98124, USA.
Paul D PharaohCentre for Cancer Genetic Epidemiology, Department of Public Health & Primary Care, University of Cambridge, Cambridge, CB2 8AR, UK.
John D PotterPublic Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, 98124, USA.
Lihong QiDepartment of Public Health Sciences, University of California, Davis, CA, 95817, USA.
Gad RennertBruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel.
Clemens SchafmayerDepartment of General and Thoracic Surgery, University Hospital Schleswig-Holstein, Campus Kiel, 24118, Kiel, Germany.
Robert E SchoenDepartment of Medicine and Epidemiology, University of Pittsburgh Medical Center, Pittsburgh, PA, 15213, USA.
Martha L SlatteryDepartment of Internal Medicine, University of Utah Health Sciences Center, Salt Lake City, UT, 84108, USA.
Mingyang SongClinical and Translational Epidemiology Unit and Division of Gastroenterology, Massachusetts General Hospital, Boston, MA, 02115, USA.
Cornelia M UlrichHuntsman Cancer Institute and Department of Population Health Sciences, University of Utah, Salt Lake City, UT, 84112, USA.
Aung K WinCentre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Parkville, VIC, 3010, Australia.
Emily WhitePublic Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, 98124, USA.
Alicja WolkInstitute of Environmental Medicine, Karolinska Institutet Solna, SE-171 77, Stockholm, Sweden.
Michael O WoodsFaculty of Medicine, Memorial University of Newfoundland, St. John's, NL, A1C 5S7, Canada.
Anna H WuDepartment of Preventive Medicine, University of Southern California Keck School of Medicine, Los Angeles, CA, 90033, USA.
Stephen B GruberDepartment of Medicine, University of Southern California Keck School of Medicine, Los Angeles, CA, 90033, USA.
Hermann BrennerDivision of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), 69120, Heidelberg, Germany.
Ulrike PetersPublic Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, 98124, USA.
Jenny Chang-ClaudeDivision of Cancer Epidemiology, German Cancer Research Center (DKFZ), 69120, Heidelberg, Germany. j.chang-claude@dkfz-heidelberg.de.
Fred Hutch Cancer Center · USUniversity of Melbourne · AUKarolinska Institutet · SEBrigham and Women's Hospital · USGerman Cancer Research Center · DEHeidelberg University · DEMount Sinai Hospital · CAUniversity of Southern California · USUniversity of Utah · USAmerican Cancer Society · USCarmel Medical Center · ILCentre Hospitalier Universitaire de Nantes · FRCentro de Investigación Biomédica en Red de Epidemiología y Salud Pública · ESHarvard University · USKaiser Permanente · USMassachusetts General Hospital · USMemorial Sloan Kettering Cancer Center · USMemorial University of Newfoundland · CANational Cancer Institute · USNational Center for Tumor Diseases · DE
Funding
X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4MTranslational Bioimaging Core Shared ResourceP30CA015704 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI Eric Collisson · 1985 to 2026
$296.4MUSC/NORRIS COMPREHENSIVE CANCER CENTER (CORE) SUPPORTP30CA014089 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI MYLES G COCKBURN · 1985 to 2026
$181.4MTRANSLATIONAL RESEARCHP30CA076292 · NCI · UNIVERSITY OF SOUTH FLORIDA · PI Christine O'Connell · 1998 to 2026
$93.5MStatistical MethodsP01CA087969 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI ROSNER, BERNARD A · 2000 to 2019
$77.8MTissue and Pathology ResourcesP50CA127003 · NCI · DANA-FARBER CANCER INST · PI BASS, ADAM JOEL · 2007 to 2023
$33.2MPLCO Trial Etiologic and Early Marker StudyZIACP010152 · NCI · DIVISION OF CANCER EPIDEMIOLOGY AND GENETICS · PI MOORE, STEVEN · 2009 to 2025
$29.9MJH/CIDR Genotyping for Genome-Wide Association StudiesU01HG004438 · NHGRI · JOHNS HOPKINS UNIVERSITY · PI VALLE, DAVID · 2007 to 2011
$24.2MGENETIC SUSCEPTIBILITY TO CANCER IN MULTIETHNIC COHORTSR01CA063464 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI HENDERSON, BRIAN E · 2001 to 2005
$23.2MMultiethnic Cohort Study of Diet and CancerR37CA054281 · NCI · UNIVERSITY OF HAWAII AT MANOA · PI KOLONEL, LAURENCE N. · 2003 to 2012
$23.2MLong Term Multidisciplinary Study of Cancer in Women: The Nurses Health StudyUM1CA186107 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI ELIASSEN, A. HEATHER, STAMPFER, MEIR · 2014 to 2023
$22.3MMolecular pathological epidemiology of colorectal cancerU01CA137088 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI PETERS, ULRIKE · 2009 to 2018
$21.8MIntramural NIH HHS Z01 CP010200NCI NIH HHS K05 CA154337NCI NIH HHS K07 CA190673NCI NIH HHS P01 CA033619NCI NIH HHS P01 CA087969NCI NIH HHS P30 CA008748NCI NIH HHS P30 CA014089NCI NIH HHS P30 CA015704NCI NIH HHS P30 CA076292NCI NIH HHS P50 CA127003NCI NIH HHS R01 CA048998NCI NIH HHS R01 CA054281NCI NIH HHS R01 CA059045NCI NIH HHS R01 CA060987NCI NIH HHS R01 CA063464NCI NIH HHS R01 CA076366NCI NIH HHS R01 CA081488NCI NIH HHS R01 CA137178NCI NIH HHS R01 CA143237NCI NIH HHS R01 CA151993NCI NIH HHS R01 CA189184NCI NIH HHS R01 CA189532NCI NIH HHS R01 CA197350NCI NIH HHS R01 CA207371NCI NIH HHS R35 CA197735NCI NIH HHS R37 CA054281NCI NIH HHS U01 CA074783NCI NIH HHS U01 CA074794NCI NIH HHS U01 CA074799NCI NIH HHS U01 CA074800NCI NIH HHS U01 CA074806NCI NIH HHS U01 CA097735NCI NIH HHS U01 CA122839NCI NIH HHS U01 CA137088NCI NIH HHS U01 CA152756NCI NIH HHS U01 CA167551NCI NIH HHS U01 CA206110NCI NIH HHS U19 CA148107NCI NIH HHS U24 CA074783NCI NIH HHS U24 CA074794NCI NIH HHS U24 CA074799NCI NIH HHS U24 CA074800NCI NIH HHS U24 CA074806NCI NIH HHS U24 CA097735NCI NIH HHS UM1 CA167551NCI NIH HHS UM1 CA186107NHGRI NIH HHS U01 HG004438NHGRI NIH HHS U01 HG004446NHLBI NIH HHS HHSN268201100001INHLBI NIH HHS HHSN268201100002INHLBI NIH HHS HHSN268201100003INHLBI NIH HHS HHSN268201100004INHLBI NIH HHS HHSN268201100046CNHLBI NIH HHS HHSN268201600001CNHLBI NIH HHS HHSN268201600002CNHLBI NIH HHS HHSN268201600003CNHLBI NIH HHS HHSN268201600004CNHLBI NIH HHS HHSN268201600018CNIA NIH HHS HHSN271201100004CNIDDK NIH HHS K01 DK110267NIH HHS S10 OD020069WHI NIH HHS HHSN268201100001CWHI NIH HHS HHSN268201100002CWHI NIH HHS HHSN268201100003CWHI NIH HHS HHSN268201100004C
Abstract
backgroundSubstantial evidence supports an association between use of menopausal hormone therapy and decreased colorectal cancer (CRC) risk, indicating a role of exogenous sex hormones in CRC development. However, findings on endogenous oestrogen exposure and CRC are inconsistent.
methodsWe used a Mendelian randomisation approach to test for a causal effect of age at menarche and age at menopause as surrogates for endogenous oestrogen exposure on CRC risk. Weighted genetic risk scores based on 358 single-nucleotide polymorphisms associated with age at menarche and 51 single-nucleotide polymorphisms associated with age at menopause were used to estimate the association with CRC risk using logistic regression in 12,944 women diagnosed with CRC and 10,741 women without CRC from three consortia. Sensitivity analyses were conducted to address pleiotropy and possible confounding by body mass index.
resultsGenetic risk scores for age at menarche (odds ratio per year 0.98, 95% confidence interval: 0.95-1.02) and age at menopause (odds ratio 0.98, 95% confidence interval: 0.94-1.01) were not significantly associated with CRC risk. The sensitivity analyses yielded similar results.
conclusionsOur study does not support a causal relationship between genetic risk scores for age at menarche and age at menopause and CRC risk.
Indexed as
Age FactorsCase-Control StudiesColorectal NeoplasmsFemaleGenetic Predisposition to DiseaseHumansLogistic ModelsMenarcheMendelian Randomization AnalysisMenopausePolymorphism, Single NucleotideRegistries
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Registered trials
NCT02328677ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.