Evidence map›Paper›PMID 29795304›Full record

ArticleScientific reports2018

NELFCD and CTSZ loci are associated with jaundice-stage progression in primary biliary cholangitis in the Japanese population.

Nao Nishida, Yoshihiro Aiba, Yuki Hitomi, Minae Kawashima, Kaname Kojima, Yosuke Kawai, Kazuko Ueno, Hitomi Nakamura, Noriyo Yamashiki, Tomohiro Tanaka and 17 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.8field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Genomics of Human Fibrotic Diseases: Disordered Wound Healing Response.International journal of molecular sciences · 2020
    Review
  8. CLEC4E (Mincle) genetic variation associates with pulmonary tuberculosis in Guinea-Bissau (West Africa).Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases · 2020
    Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

27 authors at 9 institutions in 1 country.

Nao NishidaDepartment of Human Genetics, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Yoshihiro AibaClinical Research Center, National Hospital Organization (NHO) Nagasaki Medical Center, Omura, Japan.
Yuki HitomiDepartment of Human Genetics, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Minae KawashimaDepartment of Human Genetics, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Kaname KojimaDivision of Biomedical Information Analysis, Department of Integrative Genomics, Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan.
Yosuke KawaiDivision of Biomedical Information Analysis, Department of Integrative Genomics, Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan.
Kazuko UenoDivision of Biomedical Information Analysis, Department of Integrative Genomics, Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan.
Hitomi NakamuraClinical Research Center, National Hospital Organization (NHO) Nagasaki Medical Center, Omura, Japan.
Noriyo YamashikiOrgan Transplantation Service, The University of Tokyo, Tokyo, Japan.
Tomohiro TanakaOrgan Transplantation Service, The University of Tokyo, Tokyo, Japan.
Sumito TamuraHepatobiliarypancreatic Surgery Division, Artificial Organ and Transplantation Division, Department of Surgery, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Akira MoriDivision of Hepato-Biliary-Pancreatic and Transplant Surgery, Department of Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Shintaro YagiDivision of Hepato-Biliary-Pancreatic and Transplant Surgery, Department of Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Yuji SoejimaDepartment of Surgery and Science, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan.
Tomoharu YoshizumiDepartment of Surgery and Science, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan.
Mitsuhisa TakatsukiDepartment of Transplantation and Digestive Surgery, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.
Atsushi TanakaDepartment of Medicine, Teikyo University School of Medicine, Tokyo, Japan.ORCID 0000-0002-6358-5283
Kenichi HaradaDepartment of Human Pathology, Kanazawa University Graduate School of Medicine, Kanazawa, Japan.
Shinji ShimodaDepartment of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan.
Atsumasa KomoriClinical Research Center, National Hospital Organization (NHO) Nagasaki Medical Center, Omura, Japan.
Susumu EguchiDepartment of Transplantation and Digestive Surgery, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.
Yoshihiko MaeharaDepartment of Surgery and Science, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan.
Shinji UemotoDivision of Hepato-Biliary-Pancreatic and Transplant Surgery, Department of Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Norihiro KokudoHepatobiliarypancreatic Surgery Division, Artificial Organ and Transplantation Division, Department of Surgery, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Masao NagasakiDivision of Biomedical Information Analysis, Department of Integrative Genomics, Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan.
Katsushi TokunagaDepartment of Human Genetics, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Minoru NakamuraClinical Research Center, National Hospital Organization (NHO) Nagasaki Medical Center, Omura, Japan. nakamuram@nagasaki-mc.com.
The University of Tokyo · JPKyushu University · JPNagasaki Medical Center · JPTohoku University · JPKyoto University · JPNagasaki University · JPKanazawa University · JPNational Center for Global Health and Medicine · JPTeikyo University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Approximately 10-20% of patients with primary biliary cholangitis (PBC) progress to jaundice stage regardless of treatment with ursodeoxycholic acid and bezafibrate. In this study, we performed a GWAS and a replication study to identify genetic variants associated with jaundice-stage progression in PBC using a total of 1,375 patients (1,202 early-stage and 173 jaundice-stage) in a Japanese population. SNP rs13720, which is located in the 3'UTR of cathepsin Z (CTSZ), showed the strongest association (odds ratio [OR] = 2.15, P = 7.62 × 10

Indexed as

Polymorphism, Single NucleotideQuantitative Trait LociCathepsin ZDisease ProgressionFemaleGenetic MarkersGenetic Predisposition to DiseaseGenome-Wide Association StudyGenotypeHumansJapanJaundiceLinkage DisequilibriumLiver Cirrhosis, BiliaryMaleMiddle AgedCathepsin ZCTSZ protein, humanGenetic Markersnegative elongation factorTranscription Factors

Identifiers

PMID29795304
PMCPMC5966418
OpenAlexW2803694541

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.