ArticleNature communications2018
Large-scale forward genetics screening identifies Trpa1 as a chemosensor for predator odor-evoked innate fear behaviors.
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Article in Nature communications, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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35citing papers in PubMed
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35 citing papers in PubMed, 91 citations in OpenAlex.
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- Control of defensive behavior by the nucleus of Darkschewitsch GABAergic neurons.National science review · 2024Article
- A molecularly defined amygdala-independent tetra-synaptic forebrain-to-hindbrain pathway for odor-driven innate fear and anxiety.Nature neuroscience · 2024Article
- A sex-specific thermogenic neurocircuit induced by predator smell recruiting cholecystokinin neurons in the dorsomedial hypothalamus.Nature communications · 2023Article
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- The Endocannabinoid 2-Arachidonoylglycerol Bidirectionally Modulates Acute and Protracted Effects of Predator Odor Exposure.Biological psychiatry · 2022Article
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- Neuronal Electrophysiological Activities Detection of Defense Behaviors Using an Implantable Microelectrode Array in the Dorsal Periaqueductal Gray.Biosensors · 2022Article
- Energy-sparing by 2-methyl-2-thiazoline protects heart from ischaemia/reperfusion injury.ESC heart failure · 2022Article
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Authors and funding
33 authors at 6 institutions in 3 countries.
Yibing WangNational Institute of Biological Sciences, 102206, Beijing, China.
Liqin CaoInternational Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, Tsukuba, Ibaraki, 305-8575, Japan.
Chia-Ying LeeInternational Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, Tsukuba, Ibaraki, 305-8575, Japan.
Tomohiko MatsuoFunctional Neuroscience Lab, Kansai Medical University, Hirakata, Osaka, 573-1010, Japan.
Kejia WuNational Institute of Biological Sciences, 102206, Beijing, China.
Greg AsherInternational Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, Tsukuba, Ibaraki, 305-8575, Japan.
Lijun TangFunctional Neuroscience Lab, Kansai Medical University, Hirakata, Osaka, 573-1010, Japan.
Tsuyoshi SaitohInternational Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, Tsukuba, Ibaraki, 305-8575, Japan.ORCID http://orcid.org/0000-0001-6105-6292
Jamie RussellCenter for Genetics of Host Defense, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA.
Daniela Klewe-NebeniusInternational Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, Tsukuba, Ibaraki, 305-8575, Japan.
Li WangDepartment of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA.
Shingo SoyaInternational Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, Tsukuba, Ibaraki, 305-8575, Japan.
Emi HasegawaInternational Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, Tsukuba, Ibaraki, 305-8575, Japan.
Yoan ChérasseInternational Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, Tsukuba, Ibaraki, 305-8575, Japan.ORCID http://orcid.org/0000-0002-6139-8193
Jiamin ZhouDepartment of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA.
Yuwenbin LiDepartment of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA.
Tao WangCenter for Genetics of Host Defense, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA.ORCID http://orcid.org/0000-0002-4355-149X
Xiaowei ZhanCenter for Genetics of Host Defense, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA.
Chika MiyoshiInternational Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, Tsukuba, Ibaraki, 305-8575, Japan.
Yoko IrukayamaInternational Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, Tsukuba, Ibaraki, 305-8575, Japan.
Jie CaoDepartment of Neuroscience, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA.
Julian P MeeksDepartment of Neuroscience, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA.ORCID http://orcid.org/0000-0002-7537-4491
Laurent GautronDepartment of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA.
Zhiqiang WangInternational Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, Tsukuba, Ibaraki, 305-8575, Japan.
Katsuyasu SakuraiInternational Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, Tsukuba, Ibaraki, 305-8575, Japan.
Hiromasa FunatoInternational Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, Tsukuba, Ibaraki, 305-8575, Japan.ORCID http://orcid.org/0000-0002-2787-9700
Takeshi SakuraiInternational Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, Tsukuba, Ibaraki, 305-8575, Japan.
Masashi YanagisawaInternational Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, Tsukuba, Ibaraki, 305-8575, Japan.ORCID http://orcid.org/0000-0002-7358-4022
Hiroshi NagaseInternational Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, Tsukuba, Ibaraki, 305-8575, Japan.
Reiko KobayakawaFunctional Neuroscience Lab, Kansai Medical University, Hirakata, Osaka, 573-1010, Japan.
Ko KobayakawaFunctional Neuroscience Lab, Kansai Medical University, Hirakata, Osaka, 573-1010, Japan. skobayak@me.com.
Bruce BeutlerCenter for Genetics of Host Defense, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA. bruce.beutler@utsouthwestern.edu.
Qinghua LiuNational Institute of Biological Sciences, 102206, Beijing, China. qinghua.liu@utsouthwestern.edu.
University of Tsukuba · JPThe University of Texas Southwestern Medical Center · USKansai Medical University · JPNational Institute of Biological Sciences, Beijing · CNSouthwestern Medical Center · USToho University · JP
Funding
Mutagenetic analysis of LPS responsesR37GM067759 · NIGMS · UT SOUTHWESTERN MEDICAL CENTER · PI BEUTLER, BRUCE A · 2007 to 2016
$8.6MMolecular Mechanisms of the RNAi/MicroRNA PathwaysR01GM111367 · NIGMS · UT SOUTHWESTERN MEDICAL CENTER · PI JIANG, QIU-XING, LIU, QINGHUA · 2015 to 2018
$1.4MNIGMS NIH HHS R01 GM111367NIGMS NIH HHS R37 GM067759NIH HHS GM111367NIH HHS R37GM067759
Abstract
Innate behaviors are genetically encoded, but their underlying molecular mechanisms remain largely unknown. Predator odor 2,4,5-trimethyl-3-thiazoline (TMT) and its potent analog 2-methyl-2-thiazoline (2MT) are believed to activate specific odorant receptors to elicit innate fear/defensive behaviors in naive mice. Here, we conduct a large-scale recessive genetics screen of ethylnitrosourea (ENU)-mutagenized mice. We find that loss of Trpa1, a pungency/irritancy receptor, diminishes TMT/2MT and snake skin-evoked innate fear/defensive responses. Accordingly, Trpa1
Indexed as
InstinctAnimalsBehavior, AnimalFearFemaleGenotyping TechniquesMaleMiceMice, Inbred C57BLMice, KnockoutMutagenesisNeuronsNociceptionOdorantsSmellThiazoles2-methylthiazolineThiazolesTRPA1 Cation ChannelTrpa1 protein, mouse
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.