Evidence map›Paper›PMID 29795238›Full record

ArticleEuropean journal of clinical nutrition2019

Intake of cocoa products and risk of type-2 diabetes: the multiethnic cohort.

Gertraud Maskarinec, Simone Jacobs, Yurii Shvetsov, Carol J Boushey, Veronica W Setiawan, Laurence N Kolonel, Christopher A Haiman, Loïc Le Marchand

Open access · greenAbstract readMulticenter Study
In one paragraph

Article in European journal of clinical nutrition, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Chocolate, "Food of the Gods": History, Science, and Human Health.International journal of environmental research and public health · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 6 institutions in 2 countries.

Gertraud MaskarinecEpidemiology Program, University of Hawaii Cancer Center, Honolulu, HI, USA. gertraud@cc.hawaii.edu.
Simone JacobsInstitute of Public Health, Heidelberg University, Heidelberg, Germany.
Yurii ShvetsovEpidemiology Program, University of Hawaii Cancer Center, Honolulu, HI, USA.
Carol J BousheyEpidemiology Program, University of Hawaii Cancer Center, Honolulu, HI, USA.
Veronica W SetiawanEpidemiology Program, University of Hawaii Cancer Center, Honolulu, HI, USA.
Laurence N KolonelEpidemiology Program, University of Hawaii Cancer Center, Honolulu, HI, USA.
Christopher A HaimanDepartment of Preventive Medicine, Keck School of Medicine, and Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA, USA.
Loïc Le MarchandEpidemiology Program, University of Hawaii Cancer Center, Honolulu, HI, USA.
University of Hawaiʻi at Mānoa · USUniversity of Hawaii System · USCancer Center of Hawaii · USHeidelberg University · DEUniversity of Hawaii Cancer CenterUniversity of Southern California · US

Funding

University of Hawaii Cancer Center CCSGP30CA071789 · NCI · UNIVERSITY OF HAWAII AT MANOA · PI Xin Chen · 1996 to 2026
$56.2M
Understanding Population Differences in Cancer: The MEC StudyU01CA164973 · NCI · UNIVERSITY OF HAWAII AT MANOA · PI HAIMAN, CHRISTOPHER ALAN, LE MARCHAND, LOIC · 2015 to 2025
$37.4M
Multiethnic Cohort Study of Diet and CancerR37CA054281 · NCI · UNIVERSITY OF HAWAII AT MANOA · PI KOLONEL, LAURENCE N. · 2003 to 2012
$23.2M
Understanding Ethnic Differences in Cancer: The Multiethnic Cohort StudyUM1CA164973 · NCI · UNIVERSITY OF HAWAII AT MANOA · PI HENDERSON, BRIAN E, LE MARCHAND, LOIC · 2012 to 2014
$11.3M
Nutritional Risk Factors for Type 2 Diabetes in the Multiethnic CohortR21DK073816 · NIDDK · UNIVERSITY OF HAWAII AT MANOA · PI MASKARINEC, GERTRAUD · 2007 to 2008
$389k
NCI NIH HHS P30 CA071789NCI NIH HHS R37 CA054281NCI NIH HHS U01 CA164973NCI NIH HHS UM1 CA164973NIDDK NIH HHS R21 DK073816
6 · The paper itself

Abstract

BACKGROUND/

objectivesAs cocoa products may be protective against chronic disease due to their polyphenol content, the current study determined the association of chocolate consumption and flavanol intake with type-2 diabetes (T2D) incidence in the Multiethnic Cohort (MEC) Study. SUBJECTS/

methodsThe analysis included 151,691 participants of Native Hawaiian, Japanese American, Latino, African American, and white ancestry with 8487 incident T2D cases after 7.8 ± 3.5 years of follow-up. T2D status was based on three self-reports and confirmed by at least one of three administrative data sources. Dietary intake was assessed using a validated quantitative food frequency questionnaire, and flavanols from cocoa products were estimated from self-reported consumption of chocolate candy and drinks. Cox hazard regression, adjusted for potential confounders was applied to estimate hazard ratios (HR) and 95% confidence intervals (CI).

resultsFor chocolate candy, both the highest vs. lowest (≥10 vs. <1 g/day) consumption (HR = 0.90; 95% CI, 0.83-0.97; p

conclusionsThe current study confirms previous reports that participants with high intake of chocolate products and cocoa-derived flavanols experience a reduced risk of developing T2D even after controlling for sugar intake, diet quality, and other aspects of the diet.

Indexed as

CacaoChocolateDietAgedCohort StudiesDiabetes Mellitus, Type 2EthnicityFemaleHumansIncidenceJapanMaleMiddle AgedRisk FactorsSurveys and QuestionnairesUnited States

Identifiers

PMID29795238
PMCPMC6542564
OpenAlexW2803946916

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.