ArticlePediatric research2018
Incidence of neonatal hypertension from a large multicenter study [Assessment of Worldwide Acute Kidney Injury Epidemiology in Neonates-AWAKEN].
Article in Pediatric research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to 2 registered trials, which are not on this map. Cited by 19 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Assessment of Worldwide Acute Kidney Injury Epidemiology in Neonates
Improving the Measurement of Neonatal High Blood Pressure Using the Boppli Device
Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 46 citations in OpenAlex.
- Antenatal and perinatal factors influencing neonatal blood pressure: a systematic review.Journal of perinatology : official journal of the California Perinatal Association · 2021Pooled it
- A Pathophysiological Approach for Early Detection and Prevention of AKI in the NICU.American journal of perinatology · 2026Review
- Kidney care at NICU discharge and follow-up recommendations for preterm infants<34 weeks.Journal of perinatology : official journal of the California Perinatal Association · 2026Article
- Neonatal intermittent hypoxemia events are associated with later systemic hypertension.Pediatric research · 2025Article
- Sequence of antihypertensive medications used in preterm infants with hypertension: A cross-sectional study.PloS one · 2025Article
- Blood pressure in preterm infants with bronchopulmonary dysplasia in the first three months of life.Pediatric nephrology (Berlin, Germany) · 2024Article
- Review
- A reappraisal of risk factors for hypertension after pediatric acute kidney injury.Pediatric nephrology (Berlin, Germany) · 2024Observational
- Blood Pressure Outcomes in NICU-Admitted Infants with Neonatal Hypertension: A Pediatric Nephrology Research Consortium Study.The Journal of pediatrics · 2024Article
- Neonatal hypertension: concerns within and beyond the neonatal intensive care unit.Clinical and experimental pediatrics · 2022Article
- Management of Acute Kidney Injury in Extremely Low Birth Weight Infants.Frontiers in pediatrics · 2022Review
- Neonatal acute kidney injury: a case-based approach.Pediatric nephrology (Berlin, Germany) · 2021Review
- Pediatric acute kidney injury: new advances in the last decade.Kidney research and clinical practice · 2021Article
- Improving the quality of neonatal acute kidney injury care: neonatal-specific response to the 22nd Acute Disease Quality Initiative (ADQI) conference.Journal of perinatology : official journal of the California Perinatal Association · 2021Review
- Assessment of the Cardiovascular Risk Profile of Infants Exposed to Pre-eclampsiaFrontiers in cardiovascular medicine · 2021Article
- The impact of fluid balance on outcomes in premature neonates: a report from the AWAKEN study group.Pediatric research · 2020Article
- AWAKEN-Ing a New Frontier in Neonatal Nephrology.Frontiers in pediatrics · 2020Review
- Neonatal hypertension: an educational review.Pediatric nephrology (Berlin, Germany) · 2019Review
- Improving Blood Pressure Screening in Neonatal Follow-up Clinic: A Quality Improvement Initiative.Pediatric quality & safetyArticle
Corrections and comments
- Erratum issued
Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHypertension occurs in up to 3% of neonates admitted to the Neonatal Intensive Care Unit (NICU), and is a potentially under-recognized condition. The aim of this study was to examine the incidence of documented and undiagnosed hypertension from the 24-center Assessment of Worldwide Acute Kidney Injury Epidemiology in Neonates (AWAKEN) database, and to assess risk factors for hypertension according to gestational age.
methodsDiagnosed hypertension was documented if an infant had a discharge diagnosis of hypertension and/or discharged on antihypertensive medications. Undiagnosed hypertension was defined when infants did not have a diagnosis of hypertension, but >50% of the lowest mean, diastolic and systolic blood pressure recordings were >95
resultsOf the 2162 neonates enrolled in the study, hypertension was documented in 1.8%. An additional 3.7% were defined as having undiagnosed hypertension. There was a significant correlation with neonatal hypertension and acute kidney injury (AKI). Additional risk factors for neonatal hypertension were hyperbilirubinaemia, Caucasian race, outborn, vaginal delivery, and congenital heart disease. Protective factors were small for gestational age, multiple gestations, and steroids for fetal maturation.
conclusionsNeonatal hypertension may be an under-recognized condition. AKI and other risk factors predispose infants to hypertension.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.