ArticlePediatric research2018
Gastrointestinal pathogens in anti-FH antibody positive and negative Hemolytic Uremic Syndrome.
Article in Pediatric research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 13 citations in OpenAlex.
- Anti-factor B antibodies in atypical hemolytic uremic syndrome.Pediatric nephrology (Berlin, Germany) · 2024Article
- Rotavirus-Associated Hospitalization in Children With Subsequent Autoimmune Disease.JAMA network open · 2023Article
- Clinical features of children with anti-CFH autoantibody-associated hemolytic uremic syndrome: a report of 8 cases.Renal failure · 2022Article
- Anti-factor H antibody associated hemolytic uremic syndrome following SARS-CoV-2 infection.Pediatric nephrology (Berlin, Germany) · 2022Article
- Anti-Factor H Antibodies in Egyptian Children with Hemolytic Uremic Syndrome.International journal of nephrology · 2021Article
- The complement system in liver diseases: Evidence-based approach and therapeutic options.Journal of translational autoimmunity · 2019Review
- Norovirus: a novel etiologic agent in hemolytic uremic syndrome in an infant.BMC nephrology · 2019Article
- Clinical and Immunological Profile of Anti-factor H Antibody Associated Atypical Hemolytic Uremic Syndrome: A Nationwide Database.Frontiers in immunology · 2019Article
- Rare Functional Variants in Complement Genes and Anti-FH Autoantibodies-Associated aHUS.Frontiers in immunology · 2019Article
Corrections and comments
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Authors and funding
9 authors at 7 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundProdromal symptoms are frequently reported in the atypical form of Hemolytic uremic syndrome (aHUS) suggesting implication of infectious triggers. Some pathogens may also play a role in the mechanisms of production of autoantibody directed against Factor H (FH), a complement regulator, leading to aHUS.
methodsThe presence of 15 gastrointestinal (GI) pathogens was investigated by using xTAG-based multiplex PCR techniques on stools collected at the acute phase in a cohort of Indian HUS children classified according to the presence or absence of anti-FH autoantibodies.
resultsPrevalence of pathogens in patients with anti-FH antibody (62.5%) was twice that in those without (31.5%). Different pathogens were detected, the most frequent being Clostridium difficile, Giardia intestinalis, Salmonella, Shigella, Rotavirus, Norovirus and Entamoeba histolytica. No stool was positive for Shigatoxin.
conclusionThis study reveals a higher prevalence of GI pathogens in anti-FH positive than in negative patients. No single pathogen was implicated exclusively in one form of HUS. These pathogens may play a role in the disease initiation by inducing complement activation or an autoimmune response.
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