ArticleTranslational psychiatry2018
Longitudinal and cross-sectional investigations of long-term potentiation-like cortical plasticity in bipolar disorder type II and healthy individuals.
Article in Translational psychiatry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 36 citations in OpenAlex.
- A brief visual evoked potential (VEP) modulation assessment of experience-dependent plasticity recorded via wireless dry-EEG headset in Phase 1 clinical units.Scientific reports · 2026Article
- Development of VEP-based biomarkers to assess plasticity states.Translational psychiatry · 2025Article
- The interplay between Hebbian and homeostatic plasticity in the adult visual cortex.The Journal of physiology · 2025Article
- Genetic mechanisms for impaired synaptic plasticity in schizophrenia revealed by computational modeling.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Role of microtubule actin crosslinking factor 1 (MACF1) in bipolar disorder pathophysiology and potential in lithium therapeutic mechanism.Translational psychiatry · 2023Review
- Assaying Chemical Long-Term Potentiation in Human iPSC-Derived Neuronal Networks.Methods in molecular biology (Clifton, N.J.) · 2023Article
- Probing long-term potentiation-like visual cortical plasticity in humans using repeated visual stimulation: effects on visual evoked potentials.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2023Article
- Sensory tetanisation to induce long-term-potentiation-like plasticity: A review and reassessment of the approach.The European journal of neuroscience · 2022Review
- Development of a platform to investigate long-term potentiation in human iPSC-derived neuronal networks.Stem cell reports · 2022Article
- A family study of symbolic learning and synaptic plasticity in autism spectrum disorder.Frontiers in human neuroscience · 2022Article
- Long-Term Potentiation-Like Visual Synaptic Plasticity Is Negatively Associated With Self-Reported Symptoms of Depression and Stress in Healthy Adults.Frontiers in human neuroscience · 2022Article
- Evidence for Reduced Long-Term Potentiation-Like Visual Cortical Plasticity in Schizophrenia and Bipolar Disorder.Schizophrenia bulletin · 2021Article
- Comparing the effects of crocin at different doses on excitability and long-term potentiation in the CA1 area, as well as the electroencephalogram responses of rats under chronic stress.Metabolic brain disease · 2021Article
- Insights into the Pathophysiology of Psychiatric Symptoms in Central Nervous System Disorders: Implications for Early and Differential Diagnosis.International journal of molecular sciences · 2021Review
- Visual cortical plasticity and the risk for psychosis: An interim analysis of the North American Prodrome Longitudinal Study.Schizophrenia research · 2021Article
- Transcranial direct current stimulation induces long-term potentiation-like plasticity in the human visual cortex.Translational psychiatry · 2021Article
- Sensory-Induced Human LTP-Like Synaptic Plasticity - Using Visual Evoked Potentials to Explore the Relation Between LTP-Like Synaptic Plasticity and Visual Perceptual Learning.Frontiers in human neuroscience · 2021Article
- Effects of Exercise on Long-Term Potentiation in Neuropsychiatric Disorders.Advances in experimental medicine and biology · 2020Review
- Impaired Potentiation of Theta Oscillations During a Visual Cortical Plasticity Paradigm in Individuals With Schizophrenia.Frontiers in psychiatry · 2020Article
- Childhood Adversity Is Associated With IncreasedFrontiers in psychiatry · 2018Article
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Authors and funding
12 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Visual evoked potential (VEP) plasticity is a promising assay for noninvasive examination of long-term potentiation (LTP)-like synaptic processes in the cerebral cortex. We conducted longitudinal and cross-sectional investigations of VEP plasticity in controls and individuals with bipolar disorder (BD) type II. VEP plasticity was assessed at baseline, as described previously (Elvsåshagen et al. Biol Psychiatry 2012), and 2.2 years later, at follow-up. The longitudinal sample with VEP data from both time points comprised 29 controls and 16 patients. VEP data were available from 13 additional patients at follow-up (total n = 58). VEPs were evoked by checkerboard reversals in two premodulation blocks before and six blocks after a plasticity-inducing block of prolonged (10 min) visual stimulation. VEP plasticity was computed by subtracting premodulation VEP amplitudes from postmodulation amplitudes. Saliva samples for cortisol analysis were collected immediately after awakening in the morning, 30 min later, and at 12:30 PM, at follow-up. We found reduced VEP plasticity in BD type II, that impaired plasticity was present in the euthymic phases of the illness, and that VEP plasticity correlated negatively with depression severity. There was a positive association between VEP plasticity and saliva cortisol in controls, possibly reflecting an inverted U-shaped relationship between cortisol and synaptic plasticity. VEP plasticity exhibited moderate temporal stability over a period of 2.2 years. The present study provides additional evidence for impaired LTP-like cortical plasticity in BD type II. VEP plasticity is an accessible method, which may help elucidate the pathophysiological and clinical significance of synaptic dysfunction in psychiatric disorders.
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