ArticleSpinal cord2018
Development of an International Canine Spinal Cord Injury observational registry: a collaborative data-sharing network to optimize translational studies of SCI.
Article in Spinal cord, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.
- Systematic Evaluation of Spinal Cord Injury Animal Models in the Field of Biomaterials.Tissue engineering. Part B, Reviews · 2022Pooled it
- Effect of local epidural application of methylprednisolone acetate on time to ambulation in non-ambulatory dogs with thoracolumbar intervertebral disc disease: A prospective randomised, blinded control trial.The Veterinary record · 2025Article
- Results of routine thoracic radiographic examinations rarely impact the plan to proceed with anesthetic procedures in dogs with presumed acute intervertebral disc herniation.Frontiers in veterinary science · 2024Article
- Neural stem/progenitor cells from adult canine cervical spinal cord have the potential to differentiate into neural lineage cells.BMC veterinary research · 2023Article
- Developing a predictive model for spinal shock in dogs with spinal cord injury.Journal of veterinary internal medicine · 2022Observational
- Characterization of microglia/macrophage phenotypes in the spinal cord following intervertebral disc herniation.Frontiers in veterinary science · 2022Article
- Functional Neurorehabilitation in Dogs with an Incomplete Recovery 3 Months following Intervertebral Disc Surgery: A Case Series.Animals : an open access journal from MDPI · 2021Article
- A CTSA One Health Alliance (COHA) survey of clinical trial infrastructure in North American veterinary institutions.BMC veterinary research · 2021Article
- Article
- Association between anesthesia duration and outcome in dogs with surgically treated acute severe spinal cord injury caused by thoracolumbar intervertebral disk herniation.Journal of veterinary internal medicine · 2020Article
- FAIR SCI Ahead: The Evolution of the Open Data Commons for Pre-Clinical Spinal Cord Injury Research.Journal of neurotrauma · 2020Review
- Current Approaches to the Management of Acute Thoracolumbar Disc Extrusion in Dogs.Frontiers in veterinary science · 2020Review
- Clinical Trial Design-A Review-With Emphasis on Acute Intervertebral Disc Herniation.Frontiers in veterinary science · 2020Review
- Risk factors associated with progressive myelomalacia in dogs with complete sensorimotor loss following intervertebral disc extrusion: a retrospective case-control study.BMC veterinary research · 2019Article
- Translational medicine between human and veterinary emergency and critical care medicine: a story meant to have a happy ending.Critical care (London, England) · 2019Article
- Tissue-Engineered Neural Network Graft Relays Excitatory Signal in the Completely Transected Canine Spinal Cord.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2019Article
- Urological Sequelae to Acute Spinal Cord Injury in Pet Dogs: A Natural Disease Model of Neuropathic Bladder Dysfunction.Topics in spinal cord injury rehabilitation · 2019Review
- REDCap: web-based software for all types of data storage and collection.Spinal cord · 2018Article
- Reassessment Campaign on Veterinary Resuscitation (RECOVER) Initiative Small Animal CPR Registry Report 2025.Journal of veterinary emergency and critical care (San Antonio, Tex. : 2001)Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 7 institutions in 4 countries.
Funding
Abstract
STUDY
designProspective cross-sectional cohort study.
objectivesThe canine spontaneous model of spinal cord injury (SCI) is as an important pre-clinical platform as it recapitulates key facets of human injury in a naturally occurring context. The establishment of an observational canine SCI registry constitutes a key step in performing epidemiologic studies and assessing the impact of therapeutic strategies to enhance translational research. Further, accumulating information on dogs with SCI may contribute to current "big data" approaches to enhance understanding of the disease using heterogeneous multi-institutional, multi-species datasets from both pre-clinical and human studies.
settingMultiple veterinary academic institutions across the United States and Europe.
methodsCommon data elements recommended for experimental and human SCI studies were reviewed and adapted for use in a web-based registry, to which all dogs presenting to member veterinary tertiary care facilities were prospectively entered over ~1 year.
resultsAnalysis of data accumulated during the first year of the registry suggests that 16% of dogs with SCI present with severe, sensorimotor-complete injury and that 15% of cases are seen by a tertiary care facility within 8 h of injury. Similar to the human SCI population, 34% were either overweight or obese.
conclusionsSeverity of injury and timing of presentation suggests that neuroprotective studies using the canine clinical model could be conducted efficiently using a multi-institutional approach. Additionally, pet dogs with SCI experience similar comorbidities to people with SCI, in particular obesity, and could serve as an important model to evaluate the effects of this condition.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.