Evidence map›Paper›PMID 29795033›Full record

ArticleViruses2018

K15 Protein of Kaposi's Sarcoma Herpesviruses Increases Endothelial Cell Proliferation and Migration through Store-Operated Calcium Entry.

Wei Chen, Changqing Xu, Liuqing Wang, Bing Shen, Linding Wang

Open access · goldAbstract read
In one paragraph

Article in Viruses, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.1field-weighted citation impact, top 51% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Kaposi Sarcoma, a Trifecta of Pathogenic Mechanisms.Diagnostics (Basel, Switzerland) · 2022
    Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Wei ChenDepartment of Microbiology, Anhui Medical University, Hefei 230032, China. chenwei1413@163.com.
Changqing XuDepartment of Microbiology, Anhui Medical University, Hefei 230032, China. xcq521208@163.com.
Liuqing Wang
Bing ShenDepartment of Physiology, Anhui Medical University, Hefei 230032, China. shenbing@ahmu.edu.cn.ORCID 0000-0001-7263-4748
Linding WangDepartment of Microbiology, Anhui Medical University, Hefei 230032, China. wanglinding@ahmu.edu.cn.
Anhui Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Kaposi's sarcoma (KS) is a tumor of the vascular endothelium that is caused by Kaposi's sarcoma-associated herpesvirus (KSHV). K15 of KSHV is a specific gene encoding a transmembrane protein. Two highly different forms of K15, the predominant (K15P) and minor (K15M) have been identified in different KSHV strains. In genomic locations and protein topology, two K15 alleles resemble the latent membrane protein (LMP) 1 and LMP2A of Epstein⁻Barr virus. Both K15 proteins have motifs similar to those found in LMP1 and LMP2A. K15 therefore seems to be a hybrid of a distant evolutionary relative of LMP1 and LMP2A. Ca

Indexed as

Cell MovementCalciumCell LineCell ProliferationEndothelial CellsHEK293 CellsHerpesvirus 8, HumanHumansMembrane ProteinsSarcoma, KaposiViral ProteinsCalciumK15 protein, Human herpesvirus 8Membrane ProteinsViral Proteinscell migrationcell proliferationK15Kaposi’s sarcoma-associated herpesvirusOrail1store-operated calcium entry

Identifiers

PMID29795033
PMCPMC6024707
OpenAlexW2804999348

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.