ArticleLife (Basel, Switzerland)2018
Molecular Evolution in a Peptide-Vesicle System.
Article in Life (Basel, Switzerland), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed, 44 citations in OpenAlex.
- Growth of fatty acid vesicles coupled with amino acid sequences of peptides toward evolvable protocells.Communications chemistry · 2026Article
- The Transformation Experiment of Frederick Griffith II: Inclusion of Cellular Heredity for the Creation of Novel Microorganisms.Bioengineering (Basel, Switzerland) · 2025Review
- Prebiotic Peptide Synthesis: How Did Longest Peptide Appear?Journal of molecular evolution · 2025Review
- The Origin of Life in the Early Continental Crust: A Comprehensive Model.Life (Basel, Switzerland) · 2025Article
- Alternative Pathways in Astrobiology: Reviewing and Synthesizing Contingency and Non-Biomolecular Origins of Terrestrial and Extraterrestrial Life.Life (Basel, Switzerland) · 2024Review
- The GARD Prebiotic Reproduction Model Described in Order and Complexity.Life (Basel, Switzerland) · 2024Article
- Evolution at the Origins of Life?Life (Basel, Switzerland) · 2024Review
- The 3 31 Nucleotide Minihelix tRNA Evolution Theorem and the Origin of Life.Life (Basel, Switzerland) · 2023Review
- Structural Phenomena in a Vesicle Membrane Obtained through an Evolution Experiment: A Study Based on MD Simulations.Life (Basel, Switzerland) · 2023Article
- Aliphatic Aldehydes in the Earth's Crust-Remains of Prebiotic Chemistry?Life (Basel, Switzerland) · 2022Article
- Spontaneous Formation of Functional Structures in Messy Environments.Life (Basel, Switzerland) · 2022Article
- Membrane Structure Obtained in an Experimental Evolution Process.Life (Basel, Switzerland) · 2022Article
- Binding of Dipeptides to Fatty Acid Membranes Explains Their Colocalization in Protocells but Does Not Select for Them Relative to Unjoined Amino Acids.The journal of physical chemistry. B · 2021Article
- Spontaneous emergence of membrane-forming protoamphiphiles from a lipid-amino acid mixture under wet-dry cycles.Chemical science · 2021Article
- AFM Images of Viroid-Sized Rings That Self-Assemble from Mononucleotides through Wet-Dry Cycling: Implications for the Origin of Life.Life (Basel, Switzerland) · 2020Article
- The Hot Spring Hypothesis for an Origin of Life.Astrobiology · 2020Review
- Life in The Context of Order and Complexity.Life (Basel, Switzerland) · 2020Article
- Chemical Ecosystem Selection on Mineral Surfaces Reveals Long-Term Dynamics Consistent with the Spontaneous Emergence of Mutual Catalysis.Life (Basel, Switzerland) · 2019Article
- Prebiotic amino acids bind to and stabilize prebiotic fatty acid membranes.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Based on a new model of a possible origin of life, we propose an efficient and stable system undergoing structural reproduction, self-optimization, and molecular evolution. This system is being formed under realistic conditions by the interaction of two cyclic processes, one of which offers vesicles as the structural environment, with the other supplying peptides from a variety of amino acids as versatile building blocks. We demonstrate that structures growing in a combination of both cycles have the potential to support their own existence, to undergo chemical and structural evolution, and to develop unpredicted functional properties. The key mechanism is the mutual stabilization of the peptides by the vesicles and of the vesicles by the peptides together with a constant production and selection of both. The development of the proposed system over time would not only represent one of the principles of life, but could also be a model for the formation of self-evolving structures ultimately leading to the first living cell. The experiment yields clear evidence for a vesicle-induced accumulation of membrane-interacting peptide which could be identified by liquid chromatography combined with high-resolution mass spectroscopy. We found that the selected peptide has an immediate effect on the vesicles, leading to (i) reduced vesicle size, (ii) increased vesicle membrane permeability, and (iii) improved thermal vesicle stability.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.