ArticlePsychosomatic medicine
Brain Correlates of Mental Stress-Induced Myocardial Ischemia.
Article in Psychosomatic medicine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers, 1 of them a synthesis that pooled it.
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Who cites it
49 citing papers in PubMed, 1 synthesis or guideline pooled it, 70 citations in OpenAlex.
- A meta-analysis on the prevalence, associated factors and diagnostic methods of mental stress induced myocardial ischemia.Journal of translational medicine · 2020Pooled it
- Comparison of autonomic stress reactivity in young healthy versus aging subjects with heart disease.PloS one · 2019Trial
- Non-invasive vagal nerve stimulation decreases brain activity during trauma scripts.Brain stimulationTrial
- Bidirectional brain-heart interactions in health and disease.Nature reviews. Neurology · 2026Review
- Baihe Dihuang Danshen Decoction Alleviates Myocardial Ischemia-Reperfusion Injury in Depression-Induced Rats by Inhibiting Ferroptosis.Combinatorial chemistry & high throughput screening · 2026Article
- Brain activation and heart rate variability as markers of autonomic function under stress.Scientific reports · 2025Article
- Poor Mental Health Status as a Risk Factor and Prognosticator in SMuRF-Less Acute Myocardial Infarction.Journal of clinical medicine · 2025Article
- Review
- Autonomic reactivity to mental stress is associated with cardiovascular mortality.European heart journal open · 2024Article
- Stress and cardiovascular disease: an update.Nature reviews. Cardiology · 2024Review
- Heart-brain axis: Pushing the boundaries of cardiovascular molecular imaging.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2024Review
- Imaging of the brain-heart axis: prognostic value in a European setting.European heart journal · 2024Article
- Article
- Central stress pathways in the development of cardiovascular disease.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2024Review
- Major depression is not associated with higher myocardial infarction rates: insights from a large database.Future cardiology · 2024Article
- Triglyceride-glucose index as a potential predictor of major adverse cardiovascular and cerebrovascular events in patients with coronary heart disease complicated with depression.Frontiers in endocrinology · 2024Article
- Mediating role of coping styles on the relationship between personality types and mental disorders in cardiovascular patients: a cross-sectional study in Iran.BMC psychiatry · 2023Article
- A Pilot Study of Neurobiological Mechanisms of Stress and Cardiovascular Risk.Medical research archives · 2023Article
- Disrupted resting-state functional connectivity of the thalamus in patients with coronary heart disease.Heliyon · 2023Article
- Validation of a new impedance cardiography analysis algorithm for clinical classification of stress states.Psychophysiology · 2022Article
Corrections and comments
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Authors and funding
17 authors at 1 institution in 1 country.
Funding
Abstract
objectiveCoronary artery disease (CAD) is a major cause of morbidity and mortality, and despite important advances in our understanding of this disorder, the underlying mechanisms remain under investigation. Recently, increased attention has been placed on the role of behavioral factors such as emotional stress on CAD risk. Brain areas involved in memory and the stress response, including medial prefrontal cortex, insula, and parietal cortex, also have outputs to the peripheral cardiovascular system. The purpose of this study was to assess the effects of mental stress on brain and cardiac function in patients with CAD.
methodsCAD patients (N = 170) underwent cardiac imaging with [Tc-99m] sestamibi single-photon emission tomography at rest and during a public speaking mental stress task. On another day, they underwent imaging of the brain with [O-15] water positron emission tomography (PET) during mental stress (arithmetic and public speaking) and control conditions.
resultsPatients with mental stress-induced myocardial ischemia showed increased activation with stress in anterior cingulate, inferior frontal gyrus, and parietal cortex (p < .005). This was seen with both arithmetic stress and public speaking stress. Arithmetic stress was additionally associated with left insula activation, and public speaking with right pre/postcentral gyrus and middle temporal gyrus activation (p < .005).
conclusionsThese findings suggest that mental stress-induced myocardial ischemia is associated with activation in brain areas involved in the stress response and autonomic regulation of the cardiovascular system. Altered brain reactivity to stress could possibly represent a mechanism through which stress leads to increased risk of CAD-related morbidity and mortality.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.