Trial reportMedicine2018
Tranexamic acid use during total hip arthroplasty: A single center retrospective analysis.
Trial report in Medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05325671 (Efficacy of Postoperative Pain Control Between Transarticular VS Periartiucular Multimodal Drug Infiltration in Total Hip Arthroplasty), which is not on this map. Cited by 18 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Efficacy of Postoperative Pain Control Between Transarticular VS Periartiucular Multimodal Drug Infiltration in Total Hip Arthroplasty: Double-blinded Randomized Control Trial
Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.
- Comparison of efficacy and safety between oral and intravenous administration of tranexamic acid for primary total knee/hip replacement: a meta-analysis of randomized controlled trial.Journal of orthopaedic surgery and research · 2020Pooled it
- Real-Time Coagulation Monitoring via Thromboelastography and Platelet Mapping in Total Hip Arthroplasty for a Patient with Factor XI Deficiency: A Case Report.Journal of orthopaedic case reports · 2026Article
- Intravenous versus oral tranexamic acid in shoulder arthroplasty.Archives of orthopaedic and trauma surgery · 2026Article
- Tranexamic acid in high-risk shoulder arthroplasty patients: safety across thromboembolic, cardiac, renal, and neurologic risk profiles.Archives of orthopaedic and trauma surgery · 2026Article
- Efficacy of postoperative tranexamic acid administration in patients undergoing proximal femoral tumor endoprosthesis reconstruction.Perioperative medicine (London, England) · 2026Article
- Tranexamic Acid Use in Total Hip Arthroplasty for Avascular Necrosis: A Single-Center Experience.Journal of clinical medicine · 2025Article
- Administration of Perioperative Tranexamic Acid and Range of Motion After Total Shoulder Arthroplasty.Journal of shoulder and elbow arthroplasty · 2025Article
- Tranexamic acid use in arthroscopic rotator cuff repair: a systematic review and meta-analysis of randomized controlled trials.JSES international · 2024Review
- Usage of Tranexamic Acid for Total Hip Arthroplasty: A Matched Cohort Analysis of 144,344 Patients.Journal of clinical medicine · 2024Article
- Tranexamic acid in total hip arthroplasty: An umbrella review on efficacy and safety.Journal of orthopaedics · 2024Review
- Incidence of Subclinical Deep Vein Thrombosis after Total Hip and Knee Arthroplasty Is Not Correlated with Number of Tranexamic Acid Doses.Journal of clinical medicine · 2024Article
- Predicting surgical operative time in primary total knee arthroplasty utilizing machine learning models.Archives of orthopaedic and trauma surgery · 2023Article
- [Comparison of hemostatic effect and safety in primary unilateral total hip arthroplasty receiving different anticoagulants after anti-fibrinolysis with tranexamic acid].Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery · 2020Article
- Effect of 3 different anticoagulants on hidden blood loss during total hip arthroplasty after tranexamic acid.Medicine · 2020Article
- Tranexamic Acid Combined with Compression Bandage Following Total Knee Arthroplasty Promotes Blood Coagulation: A Retrospective Analysis.BioMed research international · 2020Review
- Transfusion rate, hospital stay and cost-effectiveness of intravenous or local administration of tranexamic acid in total hip and knee arthroplasty: A single-center randomized controlled clinical study.Orthopedic reviews · 2019Article
- Intraoperative Cell Salvage for Revision Hip Arthroplasty: A 24-Year Study of Transfusion Requirements.JB & JS open accessArticle
- A break-even analysis of tranexamic acid for prevention of periprosthetic joint infection following total hip and knee arthroplasty.Journal of orthopaedicsArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTranexamic acid (TXA) is an antifibrinolytic agent that has shown promise in reducing blood loss during total hip arthroplasty (THA). Several studies have reported side effects of high-dose TXA administration, including myocardial infarction (MI), thromboembolic events, and seizures. These possible side effects have prevented the widespread adoption of TXA in the surgical community.
methodsWe conducted a retrospective chart review of 564 primary and revision THAs performed at a single academic center. Surgical patients received either no TXA or 1 g IV TXA at the beginning of surgery followed by a second bolus just before the surgical wound closure, at the surgeon's discretion. We analyzed differences in hemoglobin (Hb), hematocrit (Hct), estimated blood loss (EBL), and adverse events in patients receiving TXA versus patients not receiving TXA up to 2 days following surgery.
resultsSignificantly higher Hb and Hct values were found across all time points among patients undergoing primary posterior or revision THA who had received TXA. In addition, transfusion rates were significantly decreased in both primary posterior THAs and revision THAs when TXA was administered. Patients who received TXA experienced significantly fewer adverse events than those who did not for all surgery types.
conclusionAdministration of low-dose intravenous (IV) and intra-articular (IA) TXA does not appear to increase rates of adverse events and may be effective in minimizing blood loss, as reflected by Hb and Hct values following THA.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.