ArticleAIDS (London, England)2018
Abdominal obesity, sarcopenia, and osteoporosis are associated with frailty in men living with and without HIV.
Article in AIDS (London, England), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers, 7 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
51 citing papers in PubMed, 7 syntheses or guidelines pooled it, 73 citations in OpenAlex.
- The burden of sarcopenia in people living with HIV: a systematic review and meta-analysis across WHO regions.BMC infectious diseases · 2026Pooled it
- Risk factors for HIV-associated neurocognitive impairment and frailty in aging people with HIV in Latin America: a systematic review.BMC neurology · 2026Pooled it
- Sarcopenic Obesity in People With HIV: Diagnostic Criteria and Classification-A Scoping Review With a Meta-Analysis of Prevalence.Journal of obesity · 2026Pooled it
- A systematic review of the relationship between body composition including muscle, fat, bone, and body water and frailty in Asian residents.Nagoya journal of medical science · 2025Pooled it
- A systematic review of sarcopenia prevalence and associated factors in people living with human immunodeficiency virus.Journal of cachexia, sarcopenia and muscle · 2023Pooled it
- Guideline
- Sarcopenia in people living with the Human Immunodeficiency Virus: a systematic review and meta-analysis.European journal of clinical nutrition · 2020Pooled it
- Tesamorelin as an Adjunct to Exercise for Improving Physical Function in HIV (TRIUMPH): a clinical trial protocol.BMJ open · 2026Article
- Prevalence and factors associated with frailty among older adults with and without HIV in Kampala, Uganda.AIDS research and therapy · 2025Article
- Association Between Reduced Daily Protein Intake and Sarcopenic Obesity in Men Living with HIV: A New Screening Tool.Nutrients · 2025Article
- Determinants of Brain Atrophy in People Living with HIV: The Role of Lifestyle, Demographics, and Comorbidities.Journal of clinical medicine · 2025Article
- The Impact of HIV on Early Brain Aging-A Pathophysiological (Re)View.Journal of clinical medicine · 2024Review
- Muscle Quality and Physical Function in Men With and Without HIV.The journals of gerontology. Series A, Biological sciences and medical sciences · 2024Article
- Sarcopenic obesity and reduced BMD in young men living with HIV: body composition and sex steroids interplay.Journal of endocrinological investigation · 2024Observational
- Prevalence and associated factors related to sarcopenia in people living with HIV/AIDS.BMC infectious diseases · 2024Article
- Sarcopenic obesity and pre-sarcopenia contribute to frailty in community-dwelling Italian older people: data from the FRASNET study.BMC geriatrics · 2024Article
- The association between frailty and body composition among the elderly: Birjand Longitudinal Aging Study (BLAS).Journal of diabetes and metabolic disorders · 2024Article
- Observational
- Prevalence and Factors Associated With Frailty Among Older Adults Living With HIV Compared to Their Uninfected Peers From the Kenyan Coast.International journal of public health · 2024Article
- Combined effects of smoking and HIV infection on the occurrence of aging-related manifestations.Scientific reports · 2023Article
Corrections and comments
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Authors and funding
11 authors at 4 institutions in 1 country.
Funding
Abstract
objectiveThe relationships between frailty and body composition in older adults with HIV infection are poorly understood. We sought to describe associations between frailty and measures of body composition among adult men with HIV and without HIV. DESIGN/
methodsMen with and without HIV (age 50-69 years) in the Multicenter AIDS Cohort Study (MACS) Bone Strength Substudy were included if evaluated for frailty (by Fried phenotype) and body composition [BMI, waist circumference, abdominal visceral (VAT) and subcutaneous (SAT) adipose tissue, sarcopenia, and osteopenia/osteoporosis]. All participants with HIV infection were on antiretroviral therapy. Multivariate multinomial logistic regression models were used to determine associations of frailty with body composition.
resultsA total of 399 men, including 199 men with HIV and 200 men without HIV, both with median age 60 years, constituted our study population. Frailty prevalence was 16% (men with HIV) vs. 8% (men without HIV). HIV serostatus was associated with a 2.43 times higher odds of frailty (P = 0.01). Higher waist circumference, VAT, sarcopenia, and femoral neck osteoporosis were associated with increased odds of frailty (aOR 4.18, 4.45, 4.15, and 13.6, respectively, and all P < 0.05); BMI and SAT were not. None of these measures presented a differential association with frailty by HIV serostatus (all P > 0.20).
conclusionHigher abdominal obesity and sarcopenia were associated with frailty among men with and without HIV. Assessment of these body composition parameters may help detect frailty in the clinical setting.
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