Evidence map›Paper›PMID 29794230›Full record

ArticlePediatrics2018

Predictors of Medication Continuity in Children With ADHD.

William B Brinkman, Heidi Sucharew, Jessica Hartl Majcher, Jeffery N Epstein

Open access · bronzeAbstract read
In one paragraph

Article in Pediatrics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 3 pooled it
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 3 syntheses or guidelines pooled it, 45 citations in OpenAlex.

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  20. Attention Deficit Hyperactivity Disorder: What Are Pharmacists' Roles and Associated Outcomes?International journal of environmental research and public health · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

William B BrinkmanDepartment of Pediatrics, Cincinnati Children's Hospital and College of Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio; and bill.brinkman@cchmc.org.
Heidi SucharewDepartment of Pediatrics, Cincinnati Children's Hospital and College of Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio; and.
Jessica Hartl MajcherBowling Green State University, Bowling Green, Ohio.
Jeffery N EpsteinDepartment of Pediatrics, Cincinnati Children's Hospital and College of Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio; and.
University of Cincinnati Medical Center · USBowling Green State University · USCincinnati Children's Hospital Medical Center · US

Funding

LCenter for Clinical and Translational Science and TrainingUL1TR001425 · NCATS · UNIVERSITY OF CINCINNATI · PI MEINZEN-DERR, JAREEN, STRAWN, JEFFREY ROBERT · 2015 to 2024
$37.5M
Examining the Biological Basis of ADHDK24MH064478 · NIMH · DUKE UNIVERSITY · PI EPSTEIN, JEFF N. · 2002 to 2014
$1.4M
Medication Continuity in Children Treated for ADHDK23MH083027 · NIMH · CINCINNATI CHILDRENS HOSP MED CTR · PI BRINKMAN, WILLIAM BERNARD · 2010 to 2014
$878k
NCATS NIH HHS UL1 TR001425NIMH NIH HHS K23 MH083027NIMH NIH HHS K24 MH064478
6 · The paper itself

Abstract

objectivesTo identify predictors of attention-deficit/hyperactivity disorder (ADHD) medication continuity, hypothesizing greater continuity among children with (1) greater child acceptance of treatment, (2) parent belief in longer time course for ADHD, (3) positive differential between parent-perceived need for and concerns about medication, and (4) greater parent-perceived alliance with their child's doctor.

methodsWe conducted a prospective longitudinal cohort of 89 children aged 6 to 10 years old newly treated for ADHD by 1 of 44 pediatricians in 11 practices. Parents completed validated surveys on their beliefs about ADHD and medicine. We audited charts and obtained pharmacy dispensing records. In our analyses, we examined the relationship between predictor variables (eg, sociodemographic and clinical characteristics, quality of care, and belief measures) and short-term (first 90 days after starting medication) and long-term (91-450 days) medication continuity as defined by the number of days covered with medication.

resultsChildren had a median of 81% of days covered over 0 to 90 days and 54% of days covered over 91 to 450 days after starting medicine. In the first 90 days, medication coverage related to child age, satisfaction with information about medicine, medication titration, symptom reduction, parent beliefs about control over symptoms, uncertainty about treating with medicine, and working alliance. Long-term medication continuity related to child acceptance of treatment and differential between parent-perceived need for and concerns about medication at 3 months, not baseline factors.

conclusionsAdherence is a process that can change over time in response to experiences with treatment. Interventions are needed to promote productive interactions between pediatricians and families in support of continuity.

Indexed as

Drug MonitoringAge FactorsAttention Deficit Disorder with HyperactivityAttitude to HealthCentral Nervous System StimulantsChildFemaleHumansKentuckyLongitudinal StudiesMaleOhioParentsPatient Acceptance of Health CareProfessional-Family RelationsProspective StudiesCentral Nervous System Stimulants

Identifiers

PMID29794230
PMCPMC6317545
OpenAlexW2804527943

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.