Evidence map›Paper›PMID 29794146›Full record

Trial reportHaematologica2018

Phase 3 results for vosaroxin/cytarabine in the subset of patients ≥60 years old with refractory/early relapsed acute myeloid leukemia.

Farhad Ravandi, Ellen K Ritchie, Hamid Sayar, Jeffrey E Lancet, Michael D Craig, Norbert Vey, Stephen A Strickland, Gary J Schiller, Elias Jabbour, Arnaud Pigneux and 14 more

Abstract readClinical Trial, Phase IIILetterRandomized Controlled Trial
In one paragraph

Trial report in Haematologica, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. Review
  6. Review
  7. Review
  8. Article
  9. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors.

Farhad RavandiUniversity of Texas MD Anderson Cancer Center, Houston, TX, USA fravandi@mdanderson.org.
Ellen K RitchieWeill Cornell Medical Center, New York, NY, USA.
Hamid SayarIndiana University Simon Cancer Center, Indianapolis, IN, USA.
Jeffrey E LancetMoffitt Cancer Center, Tampa, FL, USA.
Michael D CraigWest Virginia University, Morgantown, WV, USA.
Norbert VeyInstitut Paoli-Calmettes and Aix-Marseille University, Marseille, France.
Stephen A StricklandVanderbilt-Ingram Cancer Center, Nashville, TN, USA.
Gary J SchillerDavid Geffen School of Medicine at University of California, Los Angeles, CA, USA.
Elias JabbourUniversity of Texas MD Anderson Cancer Center, Houston, TX, USA.
Arnaud PigneuxUniversité de Bordeaux, Centre Hospitalier Universitaire de Bordeaux, France.
Heinz-August HorstUniversity Hospital Schleswig-Holstein, Kiel, Germany.
Christian RécherInstitut Universitaire du Cancer de Toulouse Oncopole, Université de Toulouse III, Centre Hospitalier Universitaire de Toulouse, France.
Virginia M KlimekMemorial Sloan-Kettering Cancer Center, New York, NY, USA.
Jorge E CortesUniversity of Texas MD Anderson Cancer Center, Houston, TX, USA.
Angelo-Michele CarellaIRCCS AOU San Martino-IST, Genova, Italy.
Miklos EgyedKaposi Mor Teaching Hospital, Kaposvar, Hungary.
Utz KrugUniversitätsklinikum Münster, Germany.
Judith A FoxSunesis Pharmaceuticals, Inc., South San Francisco, CA, USA.
Adam R CraigSunesis Pharmaceuticals, Inc., South San Francisco, CA, USA.
Renee WardSunesis Pharmaceuticals, Inc., South San Francisco, CA, USA.
Jennifer A SmithSunesis Pharmaceuticals, Inc., South San Francisco, CA, USA.
Gary ActonSunesis Pharmaceuticals, Inc., South San Francisco, CA, USA.
Hagop M KantarjianUniversity of Texas MD Anderson Cancer Center, Houston, TX, USA.
Robert K StuartMedical University of South Carolina, Charleston, SC, USA.

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4M
Tumor Evolution and Metastasis ProgramP30CA016672 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Fabien Delerue · 1985 to 2026
$290.8M
NCI NIH HHS P30 CA008748
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AgedAged, 80 and overAntineoplastic Combined Chemotherapy ProtocolsCytarabineFemaleHumansLeukemia, Myeloid, AcuteMaleMiddle AgedNaphthyridinesRecurrenceThiazolesCytarabineNaphthyridinesThiazolesvosaroxin

Identifiers

PMID29794146
PMCPMC6278965

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.