Evidence map›Paper›PMID 29794136›Full record

ArticleThe Journal of biological chemistry2018

The transcription factor Vezf1 represses the expression of the antiangiogenic factor Cited2 in endothelial cells.

Lama AlAbdi, Ming He, Qianyi Yang, Allison B Norvil, Humaira Gowher

Open access · hybridAbstract read
In one paragraph

Article in The Journal of biological chemistry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 35 citations in OpenAlex.

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  9. The Role of Circular RNAs in Ischemic Stroke.Neurochemical research · 2023
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Lama AlAbdiFrom the Department of Biochemistry and.
Ming HeFrom the Department of Biochemistry and.
Qianyi YangFrom the Department of Biochemistry and.
Allison B NorvilFrom the Department of Biochemistry and.
Humaira GowherFrom the Department of Biochemistry and hgowher@purdue.edu.ORCID 0000-0002-1250-9571
Purdue University West Lafayette · US

Funding

Transgenic Mouse Core Facility Shared Resource (TMCF-SR)P30CA023168 · NCI · PURDUE UNIVERSITY WEST LAFAYETTE · PI John Tesmer · 1985 to 2026
$43.4M
Regulation of Dnmt3 Activity at Enhancers of Cell Identity Genes During DifferentiationR01GM118654 · NIGMS · PURDUE UNIVERSITY · PI GOWHER, HUMAIRA · 2017 to 2021
$1.6M
NCI NIH HHS P30 CA023168NIGMS NIH HHS R01 GM118654
6 · The paper itself

Abstract

Formation of the vasculature by angiogenesis is critical for proper development, but angiogenesis also contributes to the pathogenesis of various disorders, including cancer and cardiovascular diseases. Vascular endothelial zinc finger 1 (Vezf1), is a Krüppel-like zinc finger protein that plays a vital role in vascular development. However, the mechanism by which Vezf1 regulates this process is not fully understood. Here, we show that

Indexed as

Cell DifferentiationGene Expression RegulationAngiogenesis InhibitorsAnimalsCells, CulturedDNA-Binding ProteinsEmbryonic Stem CellsEndothelium, VascularKruppel-Like Transcription FactorsMiceMice, KnockoutPromoter Regions, GeneticRepressor ProteinsTrans-ActivatorsTranscription FactorsAngiogenesis InhibitorsCited2 protein, mouseDNA-Binding ProteinsKruppel-Like Transcription FactorsRepressor ProteinsTrans-ActivatorsTranscription FactorsVezf1 protein, mouseangiogenesiscell differentiationchromatin immunoprecipitation (ChiP)Cited2DNA methylationE1A-binding protein p300 (P300)embryonic stem cellendothelial cellgene regulationH3K27 acetylationhistone acetylationvascular endothelial growth factor (VEGF)Vezf1

Identifiers

PMID29794136
PMCPMC6052231
OpenAlexW2803969454

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.