Evidence map›Paper›PMID 29794020›Full record

ArticlePlant physiology2018

Decoys Untangle Complicated Redundancy and Reveal Targets of Circadian Clock F-Box Proteins.

Chin-Mei Lee, Ann Feke, Man-Wah Li, Christopher Adamchek, Kristofor Webb, José Pruneda-Paz, Eric J Bennett, Steve A Kay, Joshua M Gendron

Open access · bronzeAbstract read
In one paragraph

Article in Plant physiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed
13.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

42 citing papers in PubMed, 68 citations in OpenAlex.

  1. Review
  2. Review
  3. microPublication biology · 2026
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  10. A circadian clock output functions independently of phyB to sustain daytime PIF3 degradation.Proceedings of the National Academy of Sciences of the United States of America · 2024
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  12. Review
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  16. Review
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  19. SOS1 safeguards plant circadian rhythm against daily salt fluctuations.Proceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Chin-Mei LeeDepartment of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, Connecticut 06511.ORCID 0000-0003-3870-4268
Ann FekeDepartment of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, Connecticut 06511.
Man-Wah LiDepartment of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, Connecticut 06511.
Christopher AdamchekDepartment of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, Connecticut 06511.
Kristofor WebbSection of Cell and Developmental Biology, Division of Biological Sciences, University of California, San Diego, La Jolla, California 92093.ORCID 0000-0001-8111-9756
José Pruneda-PazSection of Cell and Developmental Biology, Division of Biological Sciences, University of California, San Diego, La Jolla, California 92093.
Eric J BennettSection of Cell and Developmental Biology, Division of Biological Sciences, University of California, San Diego, La Jolla, California 92093.
Steve A KayDepartment of Neurology, Keck School of Medicine, University of Southern California, Los Angeles, California 90089.
Joshua M GendronDepartment of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, Connecticut 06511 joshua.gendron@yale.edu.ORCID 0000-0001-8605-3047
Yale University · USUniversity of California San Diego · USUniversity of Southern California · US

Funding

PREDOCTORAL TRAINING PROGRAM IN GENETICST32GM007499 · NIGMS · YALE UNIVERSITY · PI CARLSON, JOHN R, REINKE, VALERIE J · 1985 to 2022
$13.9M
GENETIC ANALYSIS OF CIRCADIAN RHYTHMS IN ARABIDOPSISR01GM056006 · NIGMS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI KAY, STEVE A, PRUNEDA-PAZ, JOSE L · 1996 to 2016
$6.0M
Molecular Mechanisms in the Arabidopsis Circadian ClockR01GM067837 · NIGMS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI KAY, STEVE A · 2003 to 2015
$4.7M
Molecular Mechanisms in the Arabidopsis Circadian ClockR37GM067837 · NIGMS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI STEVE A KAY · 2017 to 2026
$4.4M
The Arabidopsis Transcription Factor ORFeome and downstream genomic applicationRC2GM092412 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ECKER, JOSEPH R, KAY, STEVE A · 2009 to 2010
$2.0M
NIGMS NIH HHS R01 GM056006NIGMS NIH HHS R01 GM067837NIGMS NIH HHS R37 GM067837NIGMS NIH HHS RC2 GM092412NIGMS NIH HHS T32 GM007499
6 · The paper itself

Abstract

Eukaryotic circadian clocks utilize the ubiquitin proteasome system to precisely degrade clock proteins. In plants, the F-box-type E3 ubiquitin ligases ZEITLUPE (ZTL), FLAVIN-BINDING, KELCH REPEAT, F-BOX1 (FKF1), and LOV KELCH PROTEIN2 (LKP2) regulate clock period and couple the clock to photoperiodic flowering in response to end-of-day light conditions. To better understand their functions, we expressed decoy ZTL, FKF1, and LKP2 proteins that associate with target proteins but are unable to ubiquitylate their targets in Arabidopsis (

Indexed as

ArabidopsisArabidopsis ProteinsCircadian ClocksFlowersGene Expression Regulation, PlantPlants, Genetically ModifiedProtein DomainsProtein Interaction MapsRepressor ProteinsUbiquitinationArabidopsis ProteinsCHE protein, ArabidopsisFKF1 protein, ArabidopsisLKP2 protein, ArabidopsisRepressor ProteinsZTL protein, Arabidopsis

Identifiers

PMID29794020
PMCPMC6052990
OpenAlexW2803408028

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.