ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2018
Classification of Neurons in the Primate Reticular Formation and Changes after Recovery from Pyramidal Tract Lesion.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed, 47 citations in OpenAlex.
- A Novel Wearable Device for Motor Recovery of Hand Function in Chronic Stroke Survivors.Neurorehabilitation and neural repair · 2020Trial
- Extent of damage to descending output from cortex rather than to specific cortical regions drives the emergence of flexor synergy in non-human primates.bioRxiv : the preprint server for biology · 2026Article
- A Spinal Origin for the Obligate Flexor Synergy in the Nonhuman Primate: Implications for Control of Reaching.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Breathing-driven modulation of reticulospinal tract activity.Experimental physiology · 2026Article
- Arm Control and its Recovery after Selective Lesions of Sensorimotor Cortex and the Red Nucleus: A Kinematic Study in Non-Human Primates.bioRxiv : the preprint server for biology · 2026Article
- Self-Organizing Recruitment of Compensatory Cortical Areas Post-Stroke Can Maximize Residual Motor Performance.IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society · 2026Article
- Transplantation of Human iPS Cell-derived Cerebral Cortical Neurons Promotes Fine Motor Recovery in a Female Mouse Model of Ischemic Stroke.Stem cell reviews and reports · 2026Article
- From thought to action: The organization of spinal projecting neurons.Cell reports · 2025Review
- A spinal origin for the obligate flexor synergy in the non-human primate: Implications for control of reaching.bioRxiv : the preprint server for biology · 2025Article
- Association of a kinematic measure of upper limb reaching and StartReact in chronic hemiparetic stroke.Experimental brain research · 2025Article
- Corticospinal and corticoreticulospinal projections have discrete but complementary roles in chronic motor behaviors after stroke.Journal of neurophysiology · 2024Article
- Pharmacologically Induced Accommodation Palsy and the Bioelectrical Activity of the Muscular System: A Preliminary Investigation.Diagnostics (Basel, Switzerland) · 2024Article
- Moving toward elucidating alternative motor pathway structures post-stroke: the value of spinal cord neuroimaging.Frontiers in neurology · 2024Review
- Adaptation of the layer V supraspinal motor corticofugal projections from the primary (M1) and premotor (PM) cortices after CNS motor disorders in non-human primates: A survey.Translational neuroscience · 2024Review
- Article
- Identifying spinal tracts transmitting distant effects of trans-spinal magnetic stimulation.Journal of neurophysiology · 2023Article
- Article
- Pairing Transcranial Magnetic Stimulation and Loud Sounds Produces Plastic Changes in Motor Output.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- The Existence of the StartReact Effect Implies Reticulospinal, Not Corticospinal, Inputs Dominate Drive to Motoneurons during Voluntary Movement.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Mapping the human corticoreticular pathway with multimodal delineation of the gigantocellular reticular nucleus and high-resolution diffusion tractography.Journal of the neurological sciences · 2022Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
The reticular formation is important in primate motor control, both in health and during recovery after brain damage. Little is known about the different neurons present in the reticular nuclei. Here we recorded extracellular spikes from the reticular formation in five healthy female awake behaving monkeys (193 cells), and in two female monkeys 1 year after recovery from a unilateral pyramidal tract lesion (125 cells). Analysis of spike shape and four measures derived from the interspike interval distribution identified four clusters of neurons in control animals. Cluster 1 cells had a slow firing rate. Cluster 2 cells had narrow spikes and irregular firing, which often included high-frequency bursts. Cluster 3 cells were highly rhythmic and fast firing. Cluster 4 cells showed negative spikes. A separate population of 42 cells was antidromically identified as reticulospinal neurons in five anesthetized female monkeys. The distribution of spike width in these cells closely overlaid the distribution for cluster 2, leading us tentatively to suggest that cluster 2 included neurons with reticulospinal projections. In animals after corticospinal lesion, cells could be identified in all four clusters. The firing rate of cells in clusters 1 and 2 was increased in lesioned animals relative to control animals (by 52% and 60%, respectively); cells in cluster 2 were also more regular and more bursting in the lesioned animals. We suggest that changes in both membrane properties and local circuits within the reticular formation occur following lesioning, potentially increasing reticulospinal output to help compensate for lost corticospinal descending drive.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.