ArticleJournal of the American Society of Nephrology : JASN2018
A NOX4/TRPC6 Pathway in Podocyte Calcium Regulation and Renal Damage in Diabetic Kidney Disease.
Open access · bronzeAbstract read
In one paragraph
Article in Journal of the American Society of Nephrology : JASN, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 86 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
86citing papers in PubMed, 1 pooled it
11.8field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
86 citing papers in PubMed, 1 synthesis or guideline pooled it, 142 citations in OpenAlex.
- Focus on podocytes: diabetic kidney disease and renal fibrosis - a global bibliometric analysis (2000-2024).Frontiers in pharmacology · 2024Pooled it
- Transient receptor potential canonical (TRPC) channels in diabetes and associated complications.Channels (Austin, Tex.) · 2026Review
- Varespladib attenuatesRedox report : communications in free radical research · 2025Article
- The effects of Cannabidiol on podocytes in vitro.Biochemical and biophysical research communications · 2025Article
- Mechanisms and Therapeutic Perspectives of Podocyte Aging in Podocytopathies.International journal of molecular sciences · 2025Review
- Renal Implications of Kappa Opioid Receptor Signaling in Sprague-Dawley Rats.Function (Oxford, England) · 2025Article
- Combining sodium-glucose co-transporter-2 inhibitor with mesenchymal stem cells and brown adipose tissue (BAT) and white adipose tissue (WAT) transplantation to mitigate the progression of diabetic kidney disease: a pre-clinical approach.Stem cell research & therapy · 2025Article
- Podocyte-Specific Expression of the Stress Response Protein REDD1 Is Necessary for Diabetes-Induced Podocytopenia.Diabetes · 2025Article
- Mechanistic Insights Into Redox Damage of the Podocyte in Hypertension.Hypertension (Dallas, Tex. : 1979) · 2025Review
- The roles of TRPC6 in renal tubular disorders: a narrative review.Renal failure · 2024Review
- Podocyte SIRPα reduction in diabetic nephropathy aggravates podocyte injury by promoting pyruvate kinase M2 nuclear translocation.Redox biology · 2024Article
- Effects of zinc in podocytes and cortical collecting duct in vitro and Dahl salt-sensitive rats in vivo.The Journal of biological chemistry · 2024Article
- Sparsentan improves glomerular hemodynamics, cell functions, and tissue repair in a mouse model of FSGS.JCI insight · 2024Article
- The mineralocorticoid receptor in diabetic kidney disease.American journal of physiology. Renal physiology · 2024Review
- Non-voltage-gated CaAmerican journal of physiology. Renal physiology · 2024Review
- Calcium signalling and transport in the kidney.Nature reviews. Nephrology · 2024Review
- Effects of insonification on repairing the renal injury of diabetic nephropathy rats.BMJ open diabetes research & care · 2024Article
- TRPC6 Knockout Alleviates Renal Fibrosis through PI3K/AKT/GSK3B Pathway.Current medical science · 2024Article
- Molecular Targets of Novel Therapeutics for Diabetic Kidney Disease: A New Era of Nephroprotection.International journal of molecular sciences · 2024Review
- Wound Repair and CaCells · 2024Review
26 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 2 institutions in 2 countries.
Daria V IlatovskayaDepartment of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin.
Gregory BlassDepartment of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin.
Oleg PalyginDepartment of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin.
Vladislav LevchenkoDepartment of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin.
Tengis S PavlovDepartment of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin.
Michael N GrzybowskiDepartment of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin.
Kristen WinsorDepartment of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin.
Leonid S ShuyskiyDepartment of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin.
Aron M GeurtsDepartment of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin.
Allen W CowleyDepartment of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin.
Lutz BirnbaumerNeurobiology Laboratory, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina; and.
Alexander StaruschenkoDepartment of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin; staruschenko@mcw.edu.ORCID 0000-0002-5190-8356
Medical College of Wisconsin · USPontificia Universidad Católica Argentina · AR
Funding
TRANSGENIC COREP60DK020595 · NIDDK · UNIVERSITY OF CHICAGO · PI BELL, GRAEME I · 1985 to 2012
$25.5MPilot and Feasibility ProgramP30DK020595 · NIDDK · UNIVERSITY OF CHICAGO · PI Raghavendra G Mirmira · 2013 to 2026
$20.9MTherapeutic Effects of mTOR Inhibition in Salt-Sensitive HypertensionP01HL116264 · NHLBI · MEDICAL COLLEGE OF WISCONSIN · PI LIANG, MINGYU · 2013 to 2021
$18.7MRenal ion channels in the control of blood pressureR35HL135749 · NHLBI · UNIVERSITY OF SOUTH FLORIDA · PI STARUSCHENKO, ALEXANDER · 2017 to 2023
$3.6MAdvanced genetic engineering technology developmentDP2OD008396 · OD · MEDICAL COLLEGE OF WISCONSIN · PI GEURTS, ARON M · 2011 to 2011
$2.3MRole of NOX4 In Kidney Function In Salt-Sensitive HypertensionR01HL122662 · NHLBI · MEDICAL COLLEGE OF WISCONSIN · PI COWLEY, ALLEN W, STARUSCHENKO, ALEXANDER · 2015 to 2018
$1.5MThe involvement of ATP-dependent inhibition of ENaC in ARPKD cystogenesisR00DK105160 · NIDDK · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI ILATOVSKAYA, DARIA · 2018 to 2020
$747kRegulation of ENaC in salt-sensitive hypertension via inflammation-induced ROS productionR00HL116603 · NHLBI · MEDICAL COLLEGE OF WISCONSIN · PI PAVLOV, TENGIS S · 2015 to 2017
$716kRegulation of ENaC in salt-sensitive hypertension via inflammation-induced ROS prK99HL116603 · NHLBI · MEDICAL COLLEGE OF WISCONSIN · PI PAVLOV, TENGIS S · 2013 to 2014
$180kThe involvement of ATP-dependent inhibition of ENaC in ARPKD cystogenesisK99DK105160 · NIDDK · MEDICAL COLLEGE OF WISCONSIN · PI ILATOVSKAYA, DARIA · 2015 to 2016
$180kNHLBI NIH HHS K99 HL116603NHLBI NIH HHS P01 HL116264NHLBI NIH HHS R00 HL116603NHLBI NIH HHS R01 HL122662NHLBI NIH HHS R35 HL135749NIDDK NIH HHS K99 DK105160NIDDK NIH HHS P30 DK020595NIDDK NIH HHS P60 DK020595NIDDK NIH HHS R00 DK105160NIH HHS DP2 OD008396
Abstract
PubMed holds no abstract for this paper.
Indexed as
Angiotensin IIAnimalsCalciumDiabetes Mellitus, ExperimentalDiabetic NephropathiesHydrogen PeroxideMaleMiceMice, KnockoutNADPH Oxidase 4PodocytesRatsRats, Inbred DahlReactive Oxygen SpeciesTRPC6 Cation ChannelTRPC Cation ChannelsAngiotensin IICalciumHydrogen PeroxideNADPH Oxidase 4Nox4 protein, mouseNox4 protein, ratReactive Oxygen SpeciesTrpc5 protein, mouseTRPC6 Cation ChannelTrpc6 protein, mouseTrpc6 protein, ratTRPC Cation Channelscalciumdiabetic nephropathyion channelNADPH oxidasepodocytereactive oxygen species
Identifiers
What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.