Trial reportChest2018
Tobacco Dependence Predicts Higher Lung Cancer and Mortality Rates and Lower Rates of Smoking Cessation in the National Lung Screening Trial.
Trial report in Chest, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
35 citing papers in PubMed, 1 synthesis or guideline pooled it, 67 citations in OpenAlex.
- Evaluating eight smoking metrics for modelling survival in non-small cell lung cancer.Cancer epidemiology · 2026Pooled it
- Trial
- The Impact of Older Age on Smoking Cessation Outcomes After Standard Advice to Quit.Journal of applied gerontology : the official journal of the Southern Gerontological Society · 2023Trial
- Trial
- Electronic cigarette use after smoking cessation and lung cancer risk.Nature medicine · 2026Article
- What does attitude towards risk tell us about the adoption of good health behaviours? Results from a telephone survey.BMC public health · 2026Article
- Sex Differences in Overall Survival Among Patients with Non-Small-Cell Lung Cancer Across Clinical Stages: A Population-Based SEER Study.Healthcare (Basel, Switzerland) · 2026Article
- Time to first cigarette after waking and risk of incident chronic respiratory diseases in males: A prospective national cohort study.Tobacco induced diseases · 2026Article
- Article
- Tobacco use and perceived risk of lung cancer in a safety-net population.Research square · 2025Article
- Article
- Nicotine dependence is associated with an increased risk of developing chronic, non-communicable inflammatory disease: a large-scale retrospective cohort study.Frontiers in psychiatry · 2025Article
- Comparing the Fagerström Test and Heaviness of Smoking Index in Predicting Smoking Abstinence in Cancer Patients.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2024Article
- Neighborhood-level deprivation and survival in lung cancer.BMC cancer · 2024Article
- Article
- A dynamic nomogram predicting symptomatic pneumonia in patients with lung cancer receiving thoracic radiation.BMC pulmonary medicine · 2024Article
- Epidemiology of Lung Cancer in Kazakhstan: Trends and Geographic Distribution.Asian Pacific journal of cancer prevention : APJCP · 2023Article
- Analysis of nicotine dependence among daily smokers in China: evidence from a cross-sectional study in Zhejiang Province.BMJ open · 2022Article
- The α5-nAChR/PD-L1 axis facilitates lung adenocarcinoma cell migration and invasion.Human cell · 2022Article
- The Influence of Cannabis and Alcohol Use on Sexuality: An Observational Study in Young People (18-30 Years).Healthcare (Basel, Switzerland) · 2021Article
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundIncorporating tobacco treatment within lung cancer screening programs has the potential to influence cessation in high-risk smokers. We aimed to better understand the characteristics of smokers within a screening cohort, correlate those variables with downstream outcomes, and identify predictors of continued smoking.
methodsThis study is a secondary analysis of the National Lung Screening Trial randomized clinical study. Tobacco dependence was evaluated by using the Fagerstrӧm Test for Nicotine Dependence, the Heaviness of Smoking Index, and time to first cigarette (TTFC); descriptive statistics were performed. Clinical outcomes (smoking cessation, lung cancer, and mortality) were assessed with descriptive statistics and χ
resultsPatients with high dependence scores were less likely to quit smoking compared with low dependence smokers (TTFC OR, 0.50 [95% CI, 0.42-0.60]). Indicators of high dependence, as measured according to all three metrics, were associated with worsening clinical outcomes. TTFC showed that patients who smoked within 5 min of waking (indicating higher dependence) had higher rates of lung cancer (2.07% for > 60 min after waking vs 5.92% ≤ 5 min after waking; hazard ratio [HR], 2.56 [95% CI, 1.49-4.41]), all-cause mortality (5.38% for > 60 min vs 11.21% ≤ 5 min; HR, 2.19 [95% CI, 1.55-3.09]), and lung cancer-specific mortality (0.55% for > 60 min vs 2.92% for ≤ 5 min; HR, 4.46 [95% CI, 1.63-12.21]).
conclusionsUsing TTFC, a one-question assessment of tobacco dependence, at the time of lung cancer screening has implications for personalizing tobacco treatment and improving risk assessment.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.