Evidence map›Paper›PMID 29793619›Full record

ArticleThe Journal of investigative dermatology2018

Modes of Action of Intravenous Immunoglobulin in Bullous Pemphigoid.

Ning Li, Donna Culton, Luis A Diaz, Zhi Liu

Open access · bronzeAbstract readComment
In one paragraph

Article in The Journal of investigative dermatology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.8field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 14 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Bullous pemphigoid.Anais brasileiros de dermatologia
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Ning LiDepartment of Dermatology, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, North Carolina, USA.
Donna CultonDepartment of Dermatology, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, North Carolina, USA.
Luis A DiazDepartment of Dermatology, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, North Carolina, USA.
Zhi LiuDepartment of Dermatology, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, North Carolina, USA; Department of Microbiology and Immunology, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, North Carolina, USA. Electronic address: zhi_liu@med.unc.edu.
University of North Carolina at Chapel Hill · US

Funding

ETIOLOGY AND PATHOGENESIS OF PEMPHIGUSR01AR032599 · NIAMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI DIAZ, LUIS A. · 1987 to 2017
$5.2M
IMMUNOPATHOGENESIS OF BULLOUS PEMPHIGOIDR01AI040768 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI LIU, ZHI · 2001 to 2016
$4.1M
PEMPHIGUS AND PEMPHIGOIDR01AR032081 · NIAMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI DIAZ, LUIS A. · 1986 to 2011
$3.3M
Eosinophils in Bullous PemphigoidR01AR070276 · NIAMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI LIU, ZHI · 2017 to 2021
$1.9M
Inflammasome-gasdermin axis in bullous pemphigoidR01AR072694 · NIAMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI LIU, ZHI, MIAO, EDWARD A · 2018 to 2022
$1.9M
Role of the matrix metalloproteinase in pemphigus autoantibody-mediated epidermalR01AR061372 · NIAMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI LI, NING · 2012 to 2016
$1.5M
NIAID NIH HHS R01 AI040768NIAMS NIH HHS R01 AR032081NIAMS NIH HHS R01 AR032599NIAMS NIH HHS R01 AR061372NIAMS NIH HHS R01 AR070276NIAMS NIH HHS R01 AR072694
6 · The paper itself

Abstract

Bullous pemphigoid is an autoantibody-mediated skin blistering disease. Previous studies revealed that intravenous Ig is therapeutic in animal models of bullous pemphigoid by saturating the IgG-protective receptor FcRn, thereby accelerating degradation of pathogenic IgG. Sasaoka et al. demonstrate that the inhibitory effects of intravenous Ig on bullous pemphigoid are also associated with negative modulation of cytokine production by keratinocytes.

Indexed as

Pemphigoid, BullousAnimalsAutoantibodiesAutoantigensImmunoglobulin GImmunoglobulins, IntravenousInterleukin-6AutoantibodiesAutoantigensImmunoglobulin GImmunoglobulins, IntravenousInterleukin-6

Identifiers

PMID29793619
PMCPMC7577376
OpenAlexW2803957444

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.