Evidence map›Paper›PMID 29793552›Full record

ArticleBMC medicine2018

A cut-off of daily sedentary time and all-cause mortality in adults: a meta-regression analysis involving more than 1 million participants.

Po-Wen Ku, Andrew Steptoe, Yung Liao, Ming-Chun Hsueh, Li-Jung Chen

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In one paragraph

Article in BMC medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 103 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
103citing papers in PubMed, 6 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

103 citing papers in PubMed, 6 syntheses or guidelines pooled it.

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  11. Pain and its association with device-measured activity patterns in older adults: age and sex differences in a population-based cross-sectional study.European review of aging and physical activity : official journal of the European Group for Research into Elderly and Physical Activity · 2026
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43 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Po-Wen KuGraduate Institute of Sports and Health, National Changhua University of Education, Changhua City, Taiwan.
Andrew SteptoeDepartment of Behavioural Science and Health, University College London, London, UK.
Yung LiaoDepartment of Health Promotion and Health Education, National Taiwan Normal University, Taipei, Taiwan.
Ming-Chun HsuehDepartment of Physical Education, National Taiwan Normal University, NO.162, He-ping East Road, Section 1, Taipei, 106, Taiwan. boxeo@ntnu.edu.tw.
Li-Jung ChenDepartment of Exercise Health Science, National Taiwan University of Sport, No. 16, Section 1, Shuang-Shih Rd., Taichung, 404, Taiwan. ljchen@gm.ntupes.edu.tw.

Funding

Ministry of Science and Technology, Taiwan (TW) 105-2628-H-018-001-MY2
6 · The paper itself

Abstract

backgroundThe appropriate limit to the amount of daily sedentary time (ST) required to minimize mortality is uncertain. This meta-analysis aimed to quantify the dose-response association between daily ST and all-cause mortality and to explore the cut-off point above which health is impaired in adults aged 18-64 years old. We also examined whether there are differences between studies using self-report ST and those with device-based ST.

methodsProspective cohort studies providing effect estimates of daily ST (exposure) on all-cause mortality (outcome) were identified via MEDLINE, PubMed, Scopus, Web of Science, and Google Scholar databases until January 2018. Dose-response relationships between daily ST and all-cause mortality were examined using random-effects meta-regression models.

resultsBased on the pooled data for more than 1 million participants from 19 studies, the results showed a log-linear dose-response association between daily ST and all-cause mortality. Overall, more time spent in sedentary behaviors is associated with increased mortality risks. However, the method of measuring ST moderated the association between daily ST and mortality risk (p < 0.05). The cut-off of daily ST in studies with self-report ST was 7 h/day in comparison with 9 h/day for those with device-based ST.

conclusionsHigher amounts of daily ST are log-linearly associated with increased risk of all-cause mortality in adults. On the basis of a limited number of studies using device-based measures, the findings suggest that it may be appropriate to encourage adults to engage in less sedentary behaviors, with fewer than 9 h a day being relevant for all-cause mortality.

Indexed as

Regression AnalysisSedentary BehaviorAdolescentAdultFemaleHumansMaleMiddle AgedMortalityProspective StudiesTime FactorsYoung AdultCut-pointInactivityRecommendationReviewSedentary behaviorSitting

Identifiers

PMID29793552
PMCPMC5998593

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.