ArticleAlzheimer's research & therapy2018
Meaning in life: resilience beyond reserve.
Article in Alzheimer's research & therapy, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
38 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Association between sense of coherence and depression in patients with chronic pain: A systematic review and meta-analysis.PloS one · 2023Pooled it
- Technologies for Monitoring Lifestyle Habits Related to Brain Health: A Systematic Review.Sensors (Basel, Switzerland) · 2019Pooled it
- Measuring Cognitive Reserve (CR) - A systematic review of measurement properties of CR questionnaires for the adult population.PloS one · 2019Pooled it
- Adjunctive Brexpiprazole for Patient Life Engagement in Major Depressive Disorder: A Canadian, Phase 4, Open-Label, Interventional Study: Brexpiprazole d'appoint pour l'engagement dans la vie des patients souffrant de trouble dépressif majeur: une étude interventionnelle canadienne ouverte de phase 4.Canadian journal of psychiatry. Revue canadienne de psychiatrie · 2024Trial
- Pathways to resilience: relationships between cognitive reserve, psychological debt, and Alzheimer's disease biomarkers.Alzheimer's research & therapy · 2026Article
- Development and validation of the engaging in life scale: long and short forms among Chinese adults with emotional distress.BMC psychology · 2026Article
- The serial mediating role of self-esteem and health literacy in the relationship between self-efficacy and benefit finding among Chinese systemic lupus erythematosus patients.Frontiers in psychology · 2026Article
- Physical activity and psychosocial profiles associated with mental health risk in community-dwelling older adults: a cross-sectional study.Frontiers in sports and active living · 2026Article
- The relationship between alexithymia, meaning in life, and quality of life in older breast cancer patients: a cross-sectional study based on variable-centered and person-centered perspectives.Frontiers in medicine · 2026Article
- Cross-Species Framework for Emotional Well-Being and Brain Aging: Lessons From Behavioral Neuroscience.JAMA psychiatry · 2025Review
- Functional brain connectivity prior to the COVID-19 outbreak predicts mental health trajectories during two years of pandemic.Psychiatry and clinical neurosciences · 2024Article
- Effect of Lurasidone on Life Engagement in Schizophrenia: Post-Hoc Analysis of the JEWEL Study.Neuropsychiatric disease and treatment · 2024Article
- The relationship of social support to posttraumatic growth in COVID-19 among college students after experiencing campus lockdown: the effects of belief in a just world and meaning in life.Frontiers in psychiatry · 2024Article
- Life engagement in people living with schizophrenia: predictors and correlates of patient life engagement in a large sample of people living in the community.Psychological medicine · 2023Article
- The effect of mobile-based logotherapy on depression, suicidal ideation, and hopelessness in patients with major depressive disorder: a mixed-methods study.Scientific reports · 2023Article
- Meaning in challenging times: Sense of meaning supports wellbeing despite pandemic stresses.SSM. Mental health · 2023Article
- Purpose in life promotes resilience to age-related brain burden in middle-aged adults.Alzheimer's research & therapy · 2023Article
- Life Engagement Improvement Following Initiation of Brexpiprazole Treatment in Patients with MDD: A Naturalistic, Retrospective Real-World Study.ClinicoEconomics and outcomes research : CEOR · 2023Article
- Cognitive functions and sense of coherence in patients with carotid artery stenosis-Preliminary report.Frontiers in psychiatry · 2023Article
- Exploring life engagement from the perspective of patients with major depressive disorder: a study using patient interviews.Journal of patient-reported outcomes · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
backgroundThe contribution of psychological factors to brain health and resilience remains poorly investigated. Furthermore, their possible interaction with 'classical' cognitive reserve (CR) estimates in predicting perceived mental health and cognitive status has not been specifically addressed.
methodsWe obtained data from 1081 adults responding to questionnaires on the three meaning in life (MiL) dimensions: purpose in life (PiL), sense of coherence (SoC), and engagement with life (EwL). A questionnaire on CR variables was also administered. The outcome measures were self-reported cognitive function and affective status (depression, stress, and anxiety). Multiple linear regression analyses were used to evaluate the association between sociodemographic variables, MiL dimensions, and CR with the two selected outcomes. Mediation analyses, adjusted for age and gender, were applied to determine whether the MiL dimensions mediated the putative effects of CR on self-reported mental and cognitive health.
resultsAll three MiL components, but not CR estimates, correlated with the self-reported affective status of the participants. Higher CR, PiL, and SoC (but not EwL) scores significantly correlated with higher perceived cognitive function. Notably, the observed association between the CR measures and self-reported cognitive function was mediated by PiL and SoC.
conclusionsPsychological MiL dimensions mediate the association between classic CR estimates and self-perceived cognitive function. Further studies on CR could consider including formal measures of such psychological factors to better understand their unique or synergistic contributions, as well as investigate the associated mechanisms maintaining brain function at older ages.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.