Evidence map›Paper›PMID 29793519›Full record

ArticleDiagnostic pathology2018

High-grade B-cell lymphoma with MYC and BCL2 rearrangements arising in a composite lymphoma.

Alison M Moore, Olga Moshkin, Gordon J Swain, Susan Crocker, David P LeBrun

Open access · goldAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Diagnostic pathology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.2field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Alison M MooreDepartment of Pathology and Molecular Medicine, Queen's University, Kingston, ON, Canada.
Olga MoshkinPeterborough Regional Health Centre, Peterborough, ON, Canada.
Gordon J SwainPeterborough Regional Health Centre, Peterborough, ON, Canada.
Susan CrockerDepartment of Pathology and Molecular Medicine, Queen's University, Kingston, ON, Canada.
David P LeBrunDepartment of Pathology and Molecular Medicine, Queen's University, Kingston, ON, Canada. dpl1@queensu.ca.ORCID http://orcid.org/0000-0002-8695-0247
Queen's University · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundWe report the first case of composite lymphoma consisting of chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL), follicular lymphoma (FL) and high-grade B-cell lymphoma with MYC and BCL2 rearrangements within the same needle biopsy in which a clonal relationship between the FL and high-grade B-cell lymphoma components was demonstrated by molecular cytogenetics. CASE PRESENTATION: An 85-year-old man presented with masses in his neck and right groin. Cutting needle biopsy of the inguinal mass revealed the three lymphoma types which were morphologically, immunophenotypically and topographically distinct. Fluorescence in situ hybridization (FISH) identified an IGH-BCL2 rearrangement in both the FL and high-grade B-cell components while a MYC rearrangement was detected in the high-grade B-cell component alone.

conclusionsOur findings suggest that the high-grade lymphoma with MYC and BCL2 translocations evolved through transformation of the FL by a process that entailed acquisition of the MYC translocation. No clonal relationship between the FL and CLL/SLL components was evident since the IGH-BCL2 rearrangement was present in in the former but not the latter. This unique case of co-localized FL, CLL/SLL, and high-grade B-cell lymphoma contributes to our understanding of the clonal relationships that may exist between the components of composite lymphomas.

Indexed as

Aged, 80 and overComposite LymphomaGene RearrangementHumansLeukemia, Lymphocytic, Chronic, B-CellLymphoma, FollicularLymphoma, Large B-Cell, DiffuseMaleProto-Oncogene Proteins c-bcl-2Proto-Oncogene Proteins c-mycProto-Oncogene Proteins c-bcl-2Proto-Oncogene Proteins c-mycBCL2Chronic lymphocytic leukemiaComposite lymphomaCytogeneticsDiffuse large B-cell lymphomaDouble-hit lymphomaFollicular lymphomaHigh-grade B-cell lymphomaMYCSmall lymphocytic lymphoma

Identifiers

PMID29793519
PMCPMC5968498
OpenAlexW2805093224

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.