Evidence map›Paper›PMID 29793164›Full record

ArticleSocial science & medicine (1982)2018

Childhood socioeconomic status and longitudinal patterns of alcohol problems: Variation across etiological pathways in genetic risk.

Peter B Barr, Judy Silberg, Danielle M Dick, Hermine H Maes

Open access · greenAbstract read
In one paragraph

Article in Social science & medicine (1982), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
5.8field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 38 citations in OpenAlex.

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  11. Review
  12. Machine-Learning prediction of comorbid substance use disorders in ADHD youth using Swedish registry data.Journal of child psychology and psychiatry, and allied disciplines · 2020
    Article
  13. Article
  14. Beyond the looking glass: recent advances in understanding the impact of environmental exposures on neuropsychiatric disease.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2020
    Review
  15. Article
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Peter B BarrDepartment of Psychology, Virginia Commonwealth University, USA. Electronic address: pbarr2@vcu.edu.
Judy SilbergVirginia Institute for Psychiatric and Behavioral Genetics, Department of Psychiatry, School of Medicine, Virginia Commonwealth University, USA; Department of Human and Molecular Genetics, School of Medicine, Virginia Commonwealth University, USA; Department of Psychiatry, School of Medicine, Virginia Commonwealth University, USA.
Danielle M DickDepartment of Psychology, Virginia Commonwealth University, USA; Department of Human and Molecular Genetics, School of Medicine, Virginia Commonwealth University, USA; College Behavioral and Emotional Health Institute, Virginia Commonwealth University, Richmond, VA, USA.
Hermine H MaesVirginia Institute for Psychiatric and Behavioral Genetics, Department of Psychiatry, School of Medicine, Virginia Commonwealth University, USA; Department of Human and Molecular Genetics, School of Medicine, Virginia Commonwealth University, USA; Department of Psychiatry, School of Medicine, Virginia Commonwealth University, USA; Massey Cancer Center, Virginia Commonwealth University, USA.
Virginia Commonwealth University · US

Funding

The development of alcohol misuse and related problems from adolescence to early midlifeR01AA015416 · NIAAA · WASHINGTON UNIVERSITY · PI DICK, DANIELLE M, SALVATORE, JESSICA E · 2005 to 2024
$7.6M
Twin, molecular, and developmental approaches to understanding alcohol misuseK02AA018755 · NIAAA · VIRGINIA COMMONWEALTH UNIVERSITY · PI DICK, DANIELLE M · 2010 to 2019
$1.3M
NIAAA NIH HHS K02 AA018755NIAAA NIH HHS R01 AA015416
6 · The paper itself

Abstract

Childhood socioeconomic status (SES) is an important aspect of early life environment associated with later life health/health behaviors, including alcohol misuse. However, alcohol misuse is modestly heritable and involves differing etiological pathways. Externalizing disorders show significant genetic overlap with substance use, suggesting an impulsivity pathway to alcohol misuse. Alcohol misuse also overlaps with internalizing disorders, suggesting alcohol is used to cope. These differing pathways could lead to different patterns over time and/or differential susceptibility to environmental conditions, such as childhood SES. We examine whether: 1) genetic risk for externalizing and internalizing disorders influence trajectories of alcohol problems across adolescence to adulthood, 2) childhood SES alters genetic risk these disorders on trajectories of alcohol problems, and 3) these patterns are consistent across sex. We find modest evidence of gene-environment interaction. Higher childhood SES increases the risk of alcohol problems in late adolescence/early adulthood, while lower childhood SES increases the risk of alcohol problems in later adulthood, but only among males at greater genetic risk of externalizing disorders. Females from lower SES families with higher genetic risk of internalizing or externalizing disorders have greater risk of developing alcohol problems.

Indexed as

Social ClassAdolescentAdultAlcoholismChildFemaleGene-Environment InteractionGenetic Predisposition to DiseaseHumansLongitudinal StudiesMaleRisk FactorsYoung AdultAlcohol misuseChildhood socioeconomic statusGene-environment interactionLife course

Identifiers

PMID29793164
PMCPMC5997543
OpenAlexW2804349419

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.