Evidence map›Paper›PMID 29792810›Full record

ArticleACS synthetic biology2018

Optogenetic Inhibition of Gα

Pimkhuan Hannanta-Anan, Brian Y Chow

Open access · greenAbstract read
In one paragraph

Article in ACS synthetic biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.0field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 19 citations in OpenAlex.

  1. Article
  2. Review
  3. Light-Inducible Deformation of Mitochondria in Live Cells.Methods in molecular biology (Clifton, N.J.) · 2025
    Article
  4. Selective optogenetic inhibition of GαProceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  5. Review
  6. Cardiac optogenetics: shining light on signaling pathways.Pflugers Archiv : European journal of physiology · 2023
    Review
  7. Review
  8. Article
  9. Review
  10. Review
  11. Optogenetic approaches to control CaCurrent opinion in physiology · 2020
    Article
  12. Optogenetic Rac1 engineered from membrane lipid-binding RGS-LOV for inducible lamellipodia formation.Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology · 2020
    Article
  13. Review
  14. Optically inducible membrane recruitment and signaling systems.Current opinion in structural biology · 2019
    Review
  15. Directly light-regulated binding of RGS-LOV photoreceptors to anionic membrane phospholipids.Proceedings of the National Academy of Sciences of the United States of America · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Pimkhuan Hannanta-AnanDepartment of Bioengineering , University of Pennsylvania , Philadelphia , Pennsylvania 19104 , United States.ORCID 0000-0002-9450-0799
Brian Y ChowDepartment of Bioengineering , University of Pennsylvania , Philadelphia , Pennsylvania 19104 , United States.ORCID 0000-0001-6784-6404
University of Pennsylvania · US

Funding

Ultrafast Genetically Encoded Voltage Indicators Designed from First PrinciplesR01NS101106 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI DISCHER, BOHDANA · 2017 to 2021
$2.2M
Optogenetic Toolbox for Studying Regulators of G-Protein Signaling in AddictionR21DA040434 · NIDA · UNIVERSITY OF PENNSYLVANIA · PI CHOW, BRIAN Y · 2015 to 2016
$385k
NIDA NIH HHS R21 DA040434NINDS NIH HHS R01 NS101106
6 · The paper itself

Abstract

As fast terminators of G-protein coupled receptor (GPCR) signaling, regulators of G-protein signaling (RGS) serve critical roles in fine-tuning second messenger levels and, consequently, cellular responses to external stimuli. Here, we report the creation of an optogenetic RGS2 (opto-RGS2) that suppresses agonist-evoked calcium oscillations by the inactivation of Gα

Indexed as

Arabidopsis ProteinsCalcium SignalingCarbacholCryptochromesFeedback, PhysiologicalGTP-Binding Protein alpha Subunits, Gq-G11HEK293 CellsHumansOptogeneticsRecombinant Fusion ProteinsRGS ProteinsSignal-To-Noise RatioStochastic ProcessesArabidopsis ProteinsCarbacholCRY2 protein, ArabidopsisCryptochromesGTP-Binding Protein alpha Subunits, Gq-G11Recombinant Fusion ProteinsRGS2 protein, humanRGS Proteinscalcium signalingoptogeneticsregulators of G-protein signaling (RGS)stochasticity

Identifiers

PMID29792810
PMCPMC6311707
OpenAlexW2804649442

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.