ArticleJournal of the American Chemical Society2018
Site-Selective Switching Strategies to Functionalize Polyazines.
Article in Journal of the American Chemical Society, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Phosphonium Ions as Activating Groups for the Selective Alkylation of Pyridines and Polyazines.Journal of the American Chemical Society · 2026Article
- Article
- Site-selective chemical reactions by on-water surface sequential assembly.Nature communications · 2023Article
- Synthesis and Functionalization of Thiophosphonium Salts: A Divergent Approach to Access Thioether, Thioester, and Dithioester Derivatives.Organic letters · 2023Article
- Late-Stage C-H Functionalization of Azines.Chemical reviews · 2023Review
- Transition Metal-Free Regioselective Phosphonation of Pyridines: Scope and Mechanism.ACS organic & inorganic Au · 2023Article
- Halogenation of the 3-position of pyridines through Zincke imine intermediates.Science (New York, N.Y.) · 2022Article
- Metal-Free Phosphination and Continued Functionalization of Pyridine: A Theoretical Study.Molecules (Basel, Switzerland) · 2022Article
- Nucleophilic C-H Etherification of Heteroarenes Enabled by Base-Catalyzed Halogen Transfer.Journal of the American Chemical Society · 2021Article
- Late-stage C-H functionalization offers new opportunities in drug discovery.Nature reviews. Chemistry · 2021Review
- Phosphorus-mediated spNature · 2021Article
- Metal-free oxidative cross-coupling enabled practical synthesis of atropisomeric QUINOL and its derivatives.Nature communications · 2021Article
- Facile Pyridine SSynlett : accounts and rapid communications in synthetic organic chemistry · 2021Article
- Late stage C-H functionalizationChemical science · 2020Review
- TPP-based mitocans: a potent strategy for anticancer drug design.RSC medicinal chemistry · 2020Review
- Selective Halogenation of Pyridines Using Designed Phosphine Reagents.Journal of the American Chemical Society · 2020Article
- Switching the site-selectivity of C-H activation in aryl sulfonamides containing strongly coordinating N-heterocycles.Chemical science · 2019Article
- Nonsymmetrical Bis-Azine Biaryls from Chloroazines: A Strategy Using Phosphorus Ligand-Coupling.Journal of the American Chemical Society · 2019Article
- Cobalt-Catalyzed Alkylation of Drug-Like Molecules and Pharmaceuticals Using Heterocyclic Phosphonium Salts.ACS catalysis · 2019Article
- Heterobiaryl synthesis by contractive C-C coupling via P(V) intermediates.Science (New York, N.Y.) · 2018Article
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Authors and funding
3 authors.
Funding
Abstract
Many drug fragments and therapeutic compounds contain multiple pyridines and diazines. Developing site-selective reactions where specific C-H bonds can be transformed in polyazine structures would enable rapid access to valuable derivatives. We present a study that addresses this challenge by selectively installing a phosphonium ion as a versatile functional handle. Inherent factors that control site-selectivity are described along with mechanistically driven approaches for site-selective switching, where the C-
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.