ArticleAnalytical chemistry2018
A Nanozyme- and Ambient Light-Based Smartphone Platform for Simultaneous Detection of Dual Biomarkers from Exposure to Organophosphorus Pesticides.
Article in Analytical chemistry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed.
- Advances in Optical Biosensors for Pesticide Detection.Research (Washington, D.C.) · 2026Review
- Prussian blue nanoparticles-based dual-mode immunochromatographic assays for norfloxacin detection in animal-derived foods.Food chemistry: X · 2025Article
- Nanozyme-Powered Multimodal Sensing for Pesticide Detection.Foods (Basel, Switzerland) · 2025Review
- An Integrated Nanosensor/Smartphone Platform for Point-of-Care Biomonitoring of Human Exposure to Pesticides.Analytical chemistry · 2025Article
- NIR-triggering cobalt single-atom enzyme switches off-to-on for boosting the interactive dynamic effects of multimodal phototherapy.Nature communications · 2025Article
- Gold/DNA-CuMolecules (Basel, Switzerland) · 2024Article
- Artificial Intelligence in Point-of-Care Testing.Annals of laboratory medicine · 2023Review
- Pd@Pt nanoparticle-linked immunosorbent assay for quantification of Collagen type II.Analytica chimica acta · 2023Article
- Aptamer-Functionalized CeACS applied materials & interfaces · 2022Article
- Recent Advances in the Immunoassays Based on Nanozymes.Biosensors · 2022Review
- Recent Advances in Rapid Detection Techniques for Pesticide Residue: A Review.Journal of agricultural and food chemistry · 2022Review
- Combating small molecule environmental contaminants: detection and sequestration using functional nucleic acids.Chemical science · 2022Review
- Tailoring noble metal nanoparticle designs to enable sensitive lateral flow immunoassay.Theranostics · 2022Review
- Smartphone-Based Dual-Channel Immunochromatographic Test Strip with Polymer Quantum Dot Labels for Simultaneous Detection of Cypermethrin and 3-Phenoxybenzoic Acid.Analytical chemistry · 2021Article
- Nanozyme-Participated Biosensing of Pesticides and Cholinesterases: A Critical Review.Biosensors · 2021Review
- Nanozymes in Point-of-Care Diagnosis: An Emerging Futuristic Approach for Biosensing.Nano-micro letters · 2021Review
- Smartphone-based imaging systems for medical applications: a critical review.Journal of biomedical optics · 2021Review
- CuMikrochimica acta · 2021Article
- Smartphone-based molecularly imprinted sensors for rapid detection of thiamethoxam residues and applications.PloS one · 2021Article
- Portable smartphone-integrated paper sensors for fluorescence detection of As(III) in groundwater.Royal Society open science · 2020Article
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
A transparent, lateral-flow test strip coupled with a smartphone-based ambient light sensor was first proposed for detecting enzymatic inhibition and phosphorylation. The principle of the platform is based on the simultaneous measurement of the total amount of the enzyme and enzyme activity to biomonitor exposure to organophosphorus (OP) pesticides. In this study, butyrylcholinesterase (BChE) was adopted as the model enzyme and ethyl paraoxon was chosen as an analyte representing OP pesticides. The total amount of BChE was quantified by a sensitive colorimetric signal originating from a sandwich immunochromatographic assay utilizing PtPd nanoparticles as a colorimetric probe, which exhibited excellent catalytic activity for phenols. In the sandwich immunoassay, only one antibody against BChE was simultaneously utilized as the recognition antibody and the labeling antibody due to the tetrameric structure of native BChE. The BChE activity was estimated by another colorimetric signal using the Ellman assay. Both colorimetric signals on two separated test strips were detected by the smartphone-based ambient light sensor. The proposed sensor operated with an LED in a 3D-printed substrate, which emitted excitation light and transmitted it through a transparent, lateral-flow test strip. With the increase in the colorimetric signal in the test line of the test strip, the intensity of the transmitted light decreased. The smartphone-based sensor showed excellent linear responses for assaying the total amount of BChE and active BChE ranging from 0.05 to 6.4 nM and from 0.1 to 6.4 nM, respectively. A high portability and low detection limit were simultaneously realized in the common smartphone-based device. This low-cost, portable, easy-operation, and sensitive immunoassay strategy shows great potential for online detection of OP exposure and monitoring other disease biomarkers.
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