Evidence map›Paper›PMID 29792531›Full record

ArticleAmerican journal of physiology. Gastrointestinal and liver physiology2018

Expression of lysophosphatidic acid receptor 5 is necessary for the regulation of intestinal Na

Kayte A Jenkin, Peijian He, C Chris Yun

Open access · bronzeAbstract read
In one paragraph

Article in American journal of physiology. Gastrointestinal and liver physiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
0.6field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 20 citations in OpenAlex.

  1. Article
  2. Is LPAR5 agonist a new treatment for microvilli inclusion disease?American journal of physiology. Gastrointestinal and liver physiology · 2025
    Article
  3. Article
  4. LPAAmerican journal of physiology. Gastrointestinal and liver physiology · 2024
    Article
  5. Article
  6. Metformin Inhibits NaFrontiers in physiology · 2022
    Article
  7. Survival of Stem Cells and Progenitors in the Intestine Is Regulated by LPACellular and molecular gastroenterology and hepatology · 2022
    Article
  8. Article
  9. Article
  10. Review
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Kayte A JenkinDivision of Digestive Diseases, Department of Medicine, Emory University School of Medicine , Atlanta, Georgia.
Peijian HeDivision of Digestive Diseases, Department of Medicine, Emory University School of Medicine , Atlanta, Georgia.
C Chris YunDivision of Digestive Diseases, Department of Medicine, Emory University School of Medicine , Atlanta, Georgia.
Emory University · USVeterans Health Administration · US

Funding

Winship Cancer Institute Cancer Center Support GrantP30CA138292 · NCI · EMORY UNIVERSITY · PI Suresh S Ramalingam · 2009 to 2026
$47.5M
Regulation of NHE3 by glucocorticoids, SGK1 and NHERF2R01DK061418 · NIDDK · EMORY UNIVERSITY · PI YUN, CHANGHYON CHRIS · 2003 to 2015
$4.0M
Regulation of Human NHE3 by UbiquitinationR01DK107719 · NIDDK · EMORY UNIVERSITY · PI YUN, CHANGHYON CHRIS · 2016 to 2019
$1.4M
BLRD VA I01 BX002540National Cancer Institute P30 CA138292NIDDK NIH HHS R01 DK061418NIDDK NIH HHS R01 DK107719
6 · The paper itself

Abstract

Lysophosphatidic acid (LPA) is a bioactive lipid molecule, which regulates a broad range of pathophysiological processes. Recent studies have demonstrated that LPA modulates electrolyte flux in the intestine, and its potential as an antidiarrheal agent has been suggested. Of six LPA receptors, LPA

Indexed as

AnimalsEnterocytesIntestinal AbsorptionLysophospholipidsMiceMice, Inbred C57BLProtein TransportReceptors, Lysophosphatidic AcidSodium-Hydrogen Exchanger 3LPAR5 protein, mouselysophosphatidic acidLysophospholipidsReceptors, Lysophosphatidic AcidSlc9a3 protein, mouseSodium-Hydrogen Exchanger 3LPAmouseNHE3

Identifiers

PMID29792531
PMCPMC6230692
OpenAlexW2806714026

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.