SynthesisPsychological medicine2019
Affective problems and decline in cognitive state in older adults: a systematic review and meta-analysis.
Synthesis in Psychological medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 75 papers, 5 of them syntheses that pooled it.
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Who cites it
75 citing papers in PubMed, 5 syntheses or guidelines pooled it.
- Risk and protective factors associated with depressive symptoms in older adults with visual impairment: a systematic review.The Gerontologist · 2026Pooled it
- Cognitive impairment and depression: Meta-analysis of structural magnetic resonance imaging studies.NeuroImage. Clinical · 2021Pooled it
- Prevalence of mental disorders among elderly men: a systematic review and meta-analysis.Sao Paulo medical journal = Revista paulista de medicina · 2020Pooled it
- Evidence for Structural and Functional Alterations of Frontal-Executive and Corticolimbic Circuits in Late-Life Depression and Relationship to Mild Cognitive Impairment and Dementia: A Systematic Review.Frontiers in neuroscience · 2020Pooled it
- Road Traffic Noise Exposure and Depression/Anxiety: An Updated Systematic Review and Meta-Analysis.International journal of environmental research and public health · 2019Pooled it
- Depression and cognition: is there a bidirectional relationship?Aging & mental health · 2026Article
- Association of low sleep efficiency and carotid plaque with cognitive impairment in older adults with chronic diseases: A retrospective cross-sectional study.The Journal of international medical research · 2026Article
- Benefit and Uptake: A Mixed Methods Study Exploring Older Adults' Experiences With a Psychoeducational and Exercise Training Maintenance Intervention.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2026Article
- Psychometric Properties of the Italian Adaptation of the Subjective Cognitive Reserve Questionnaire Based on Modifiable Lifestyle Factors (SCR-Q).Healthcare (Basel, Switzerland) · 2026Article
- Longitudinal associations of psychological distress with subsequent cognitive decline and dementia: a multi-cohort study.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Characterizing olfaction, anxiety, and depression in subjective cognitive decline.Journal of Alzheimer's disease : JAD · 2026Article
- Clinical Effectiveness of Treatments for Mild Cognitive Impairment in Adults: A Systematic Review.European journal of investigation in health, psychology and education · 2025Review
- Wellbeing and memory function: testing bidirectional associations in the English Longitudinal Study of Ageing (ELSA).Aging & mental health · 2025Article
- Perceived stress shapes symptom and social network dynamics: a network analysis of depression, anxiety, and relationship-specific support and strain.BMC psychiatry · 2025Article
- Temporal Associations Between Cognitive Impairment and Depression in Older Adults: A Longitudinal Analysis.European journal of investigation in health, psychology and education · 2025Article
- The role of plasma inflammatory markers in late-life depression and conversion to dementia: a 3-year follow-up study.Molecular psychiatry · 2025Article
- Quality of life, religion/spirituality, and dementia risk among Black people in the US.Aging & mental health · 2025Observational
- Association of Life's Crucial 9 with cognitive function and stroke risk: insights from the NHANES 2011-2014 study.BMC public health · 2025Article
- History of chronic pain and opioid use is associated with cognitive decline and mild cognitive impairment.Journal of the International Neuropsychological Society : JINS · 2025Article
- [Effects of a personalised, adapted computerised cognitive stimulation programme versus stimulating leisure activities in younger and older adults with mild or subjective cognitive impairment. Protocol for a randomised controlled trial].Anales del sistema sanitario de Navarra · 2025Article
15 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
Evidence suggests that affective problems, such as depression and anxiety, increase risk for late-life dementia. However, the extent to which affective problems influence cognitive decline, even many years prior to clinical diagnosis of dementia, is not clear. The present study systematically reviews and synthesises the evidence for the association between affective problems and decline in cognitive state (i.e., decline in non-specific cognitive function) in older adults. An electronic search of PubMed, PsycInfo, Cochrane, and ScienceDirect was conducted to identify studies of the association between depression and anxiety separately and decline in cognitive state. Key inclusion criteria were prospective, longitudinal designs with a minimum follow-up period of 1 year. Data extraction and methodological quality assessment using the STROBE checklist were conducted independently by two raters. A total of 34 studies (n = 71 244) met eligibility criteria, with 32 studies measuring depression (n = 68 793), and five measuring anxiety (n = 4698). A multi-level meta-analysis revealed that depression assessed as a binary predictor (OR 1.36, 95% CI 1.05-1.76, p = 0.02) or a continuous predictor (B = -0.008, 95% CI -0.015 to -0.002, p = 0.012; OR 0.992, 95% CI 0.985-0.998) was significantly associated with decline in cognitive state. The number of anxiety studies was insufficient for meta-analysis, and they are described in a narrative review. Results of the present study improve current understanding of the temporal nature of the association between affective problems and decline in cognitive state. They also suggest that cognitive function may need to be monitored closely in individuals with affective disorders, as these individuals may be at particular risk of greater cognitive decline.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.