Evidence map›Paper›PMID 29792238›Full record

ArticlePsychological medicine2019

Mapping the neuroanatomic substrates of cognition in familial attention deficit hyperactivity disorder.

Rachel Muster, Saadia Choudhury, Wendy Sharp, Steven Kasparek, Gustavo Sudre, Philip Shaw

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Article in Psychological medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. An examination of the relationships between attention/deficit hyperactivity disorder symptoms and functional connectivity over time.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2022
    Article
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Rachel MusterNeurobehavioral Clinical Research Section, Social and Behavioral Research Branch,National Human Genome Research Institute, and the National Institute of Mental Health, NIH,Building 31, Bethesda B1B37,USA.
Saadia ChoudhuryNeurobehavioral Clinical Research Section, Social and Behavioral Research Branch,National Human Genome Research Institute, and the National Institute of Mental Health, NIH,Building 31, Bethesda B1B37,USA.
Wendy SharpNeurobehavioral Clinical Research Section, Social and Behavioral Research Branch,National Human Genome Research Institute, and the National Institute of Mental Health, NIH,Building 31, Bethesda B1B37,USA.
Steven KasparekNeurobehavioral Clinical Research Section, Social and Behavioral Research Branch,National Human Genome Research Institute, and the National Institute of Mental Health, NIH,Building 31, Bethesda B1B37,USA.
Gustavo SudreNeurobehavioral Clinical Research Section, Social and Behavioral Research Branch,National Human Genome Research Institute, and the National Institute of Mental Health, NIH,Building 31, Bethesda B1B37,USA.
Philip ShawNeurobehavioral Clinical Research Section, Social and Behavioral Research Branch,National Human Genome Research Institute, and the National Institute of Mental Health, NIH,Building 31, Bethesda B1B37,USA.

Funding

Intramural NIH HHS Z99 MH999999
6 · The paper itself

Abstract

backgroundWhile the neuroanatomic substrates of symptoms of attention deficit hyperactivity disorder (ADHD) have been investigated, less is known about the neuroanatomic correlates of cognitive abilities pertinent to the disorder, particularly in adults. Here we define the neuroanatomic correlates of key cognitive abilities and determine if there are associations with histories of psychostimulant medication.

methodsWe acquired neuroanatomic magnetic resonance imaging data from 264 members of 60 families (mean age 29.5; s.d. 18.4, 116 with ADHD). Using linear mixed model regression, we tested for associations between cognitive abilities (working memory, information processing, intelligence, and attention), symptoms and both cortical and subcortical volumes.

resultsSymptom severity was associated with spatial working memory (t = -3.77, p = 0.0002), processing speed (t = -2.95, p = 0.004) and a measure of impulsive responding (t = 2.19, p = 0.03); these associations did not vary with age (all p > 0.1). Neuroanatomic associations of cognition varied by task but centered on prefrontal, lateral parietal and temporal cortical regions, the thalamus and putamen. The neuroanatomic correlates of ADHD symptoms overlapped significantly with those of working memory (Dice's overlap coefficient: spatial, p = 0.003; verbal, p = 0.001) and information processing (p = 0.02). Psychostimulant medication history was associated with neither cognitive skills nor with a brain-cognition relationships.

conclusionsDiagnostic differences in the cognitive profile of ADHD does not vary significantly with age; nor were cognitive differences associated with psychostimulant medication history. The neuroanatomic substrates of working memory and information overlapped with those for symptoms within these extended families, consistent with a pathophysiological role for these cognitive skills in familial ADHD.

Indexed as

Brain MappingCognitionAdultAttentionAttention Deficit Disorder with HyperactivityBrainChildFamilyFemaleHumansIntelligenceMagnetic Resonance ImagingMaleMemory, Short-TermNeuroimagingNeuropsychological TestsADHDattention deficit hyperactivity disorderfamilial ADHDpsychiatrypsychostimulant

Identifiers

PMID29792238
PMCPMC6252155

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.