ArticleBrazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica2018
Chemical characterization, antioxidant and antimicrobial activity of propolis obtained from Melipona quadrifasciata quadrifasciata and Tetragonisca angustula stingless bees.
Article in Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 101 citations in OpenAlex.
- Chemical Composition and Biological Activities of Geopropolis From Four Melipona Species From the Brazilian Atlantic Forest.Chemistry & biodiversity · 2026Article
- Uncovering the antiproliferative potential of Lobophytum pauciflorum metabolites through chemoinformatics and in vitro approaches.Scientific reports · 2026Article
- A Deep Metagenomic Snapshot as a Proof-of-Concept for Resource Generation: Simultaneous Assembly of Host, Food, and Microbiome Genomes From Stingless Bee Larval Food.Ecology and evolution · 2025Article
- Quality assessment and chemical diversity of Australian propolis from Tetragonula carbonaria and Tetragonula hockingsi stingless bees.Scientific reports · 2025Article
- Chemical Characterization and Antibiotic-Enhancing Activity of the Essential Oils of Propolis ofPlants (Basel, Switzerland) · 2025Article
- The Comparative Study of the Antioxidant and Antibacterial Effects of Propolis Extracts in Veterinary Medicine.Veterinary sciences · 2024Article
- Evaluation of the antinociceptive activities of natural propolis extract derived from stingless beeThe Korean journal of pain · 2024Article
- In Vitro Antimycotic Activity and Structural Damage against CanineVeterinary sciences · 2024Article
- Antioxidant and anti-Alzheimer's potential of Tetragonisca angustula (Jataí) stingless bee pollen.Scientific reports · 2024Article
- Article
- Exploring the Functional Properties of Propolis, Geopropolis, and Cerumen, with a Special Emphasis on Their Antimicrobial Effects.Foods (Basel, Switzerland) · 2023Review
- Phenolic Content and Bioactivity as Geographical Classifiers of Propolis from Stingless Bees in Southeastern Mexico.Foods (Basel, Switzerland) · 2023Article
- Antimicrobial Activity of Propolis from the Brazilian Stingless BeesMicroorganisms · 2022Article
- Therapeutic Potential of Honey and Propolis on Ocular Disease.Pharmaceuticals (Basel, Switzerland) · 2022Review
- Chemical Composition and Biological Activity of Argentinian Propolis of Four Species of Stingless Bees.Molecules (Basel, Switzerland) · 2022Article
- Chemical Profiling, Antioxidant, and Antimicrobial Activity of Saudi Propolis Collected by Arabian Honey Bee (Antioxidants (Basel, Switzerland) · 2022Article
- Active Potential of Bacterial Cellulose-Based Wound Dressing: Analysis of Its Potential for Dermal Lesion Treatment.Pharmaceutics · 2022Article
- Antimicrobial activity of supernatants produced by bacteria isolated from Brazilian stingless bee's larval food.BMC microbiology · 2022Article
- Propolis characterization and antimicrobial activities againstSaudi journal of biological sciences · 2022Review
- Synergistic Effect of Polyphenol-Rich Complex of Plant and Green Propolis Extracts with Antibiotics against Respiratory Infections Causing Bacteria.Antibiotics (Basel, Switzerland) · 2022Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In this study, we investigated the chemical composition, and antioxidant and antibacterial properties of ethanolic extracts of propolis (EEP) from Melipona quadrifasciata quadrifasciata and Tetragonisca angustula. Chemical composition of EEP was determined by colorimetry and chromatographic (HPLC-DAD and UPLC-Q/TOF-MS/MS) analysis. Antimicrobial activity of EEP was evaluated against gram-positive (S. aureus, methicillin-resistant S. aureus, E. faecalis) and gram-negative (E. coli and K. pneumoniae) bacteria by the minimal inhibitory concentration (MIC) test using the microdilution method. Furthermore, the growth curve and integrity of cell membrane of S. aureus and E. coli were investigated using standard microbiological methods. HPLC-DAD analysis showed that the EEP of M. quadrifasciata quadrifasciata has a more complex chemical composition than the EEP of T. angustula. Moreover, UPLC-MS analyses of M. quadrifasciata quadrifascita indicated flavonoids and terpenes as major constituents. The bactericidal activity of both EEPs was higher against gram-positive bacteria than for gram-negative bacteria. The EEP from M. quadrifasciata quadrifasciata presented MIC values lower than the EEP from T. angustula for all tested bacteria. The EEP from M. quadrifasciata quadrifasciata caused lysis of the bacterial wall and release of intracellular components from both E. coli and S. aureus. Our findings indicate that the chemical composition of propolis from stingless bees is complex and depends on the species. The extract from M. quadrifasciata quadrifascita was more effective against gram-positive than gram-negative strains, especially against S. aureus and methicillin-resistant S. aureus compared to T. angustula extract, by a mechanism that involves disturbance of the bacterial cell membrane integrity.
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