ArticleJournal of applied oral science : revista FOB2018
Osteoradionecrosis of the jaws: case series treated with adjuvant low-level laser therapy and antimicrobial photodynamic therapy.
Article in Journal of applied oral science : revista FOB, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
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The trial behind it
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 77 citations in OpenAlex.
- Therapeutic alternatives in the management of osteoradionecrosis of the jaws. Systematic review.Medicina oral, patologia oral y cirugia bucal · 2021Pooled it
- Antimicrobial Photodynamic Therapy Associated With Systemic Treatment in Osteoradionecrosis: An In Vivo Study.Lasers in surgery and medicine · 2026Article
- Recent Advances in Caries Prevention and Non-Invasive Management: From Ecological Modulation to Precision Interventions.Dentistry journal · 2026Review
- Photodynamic Therapy and Photobiomodulation in the Treatment of Osteonecrosis: A Series of Cases.Journal of lasers in medical sciences · 2026Article
- Review
- Chronic Pain in the Cancer Survivor.Current pain and headache reports · 2025Review
- Autofluorescence-Guided Surgery in the Management of Osteonecrosis of the Jaw: Correlation Between Bone Autofluorescence and Histopathological Findings in 56 Samples.Life (Basel, Switzerland) · 2025Article
- Oral Ulceration With Bone Sequestration: Diagnostic Challenge, Management Strategy.Clinical case reports · 2025Article
- Effectiveness of a protocol with antimicrobial photodynamic therapy for treating osteoradionecrosis: a retrospective study.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025Article
- Combination of Different Laser Wavelengths as a Treatment Strategy for Maxillary Osteonecrosis: A Case Report.Journal of lasers in medical sciences · 2025Article
- Role of Photodynamic Therapy in Osteonecrosis and Osteoradionecrosis of the Jaws: A Systematic Review.Journal of maxillofacial and oral surgery · 2024Review
- A Systematic Review of Laser Photobiomodulation Dosimetry and Treatment Protocols in the Management of Medications-Related Osteonecrosis of the Jaws: A Rationalised Consensus for Future Randomised Controlled Clinical Trials.Pharmaceuticals (Basel, Switzerland) · 2024Review
- Pre- and Post-Operative Quality of Life in Patients with Osteoradionecrosis of the Jaw.Cancers · 2024Article
- Oral Complications and Management Strategies for Cancer Patients: Principles of Supportive Oncology in Dentistry.Current oncology reports · 2024Review
- The Role of Dental Practitioners in the Management of Oncology Patients: The Head and Neck Radiation Oncology Patient and the Medical Oncology Patient.Dentistry journal · 2023Review
- Effects of dose-dependent response to gamma radiation on circumvallate papilla by expression of caspase-3 in vivo.The Saudi dental journal · 2021Article
- [Progress on photodynamic therapy in oral diseases].Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology · 2021Review
- Photodynamic Therapy as an adjunct in the Treatment of Medication-Related Osteonecrosis of the Jaw: A Case Report.Journal of lasers in medical sciences · 2021Article
- Osteoradionecrosis of the Midface and Mandible: Pathogenesis and Management.Seminars in plastic surgery · 2020Review
- Use of Laser Systems in Orthodontics.Turkish journal of orthodontics · 2020Review
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundOsteoradionecrosis of the jaw (ORNJ) is the most severe and complex sequel of head and neck radiotherapy (RT) because of the bone involved, it may cause pain, paresthesia, foul odor, fistulae with suppuration, need for extra oral communication and pathological fracture. We treated twenty lesions of ORNJ using low-level laser therapy (LLLT) and antimicrobial photodynamic therapy (aPDT). The objective of this study was to stimulate the affected area to homeostasis and to promote the healing of the oral mucosa.
methodsWe performed aPDT on the exposed bone, while LLLT was performed around the bone exposure (red spectrum) and on the affected jaw (infrared spectrum). Monitoring and clinical intervention occurred weekly or biweekly for 2 years.
results100% of the sample presented clinical improvement, and 80% presented complete covering of the bone exposure by intact oral mucosa.
conclusionLLLT and aPDT showed positive results as an adjuvant therapy to treat ORNJ.
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Registered trials
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