Evidence map›Paper›PMID 29791556›Full record

ArticleJornal brasileiro de pneumologia : publicacao oficial da Sociedade Brasileira de Pneumologia e Tisilogia2018

Clinical aspects in patients with pulmonary infection caused by mycobacteria of the Mycobacterium abscessus complex, in the Brazilian Amazon.

José Tadeu Colares Monteiro, Karla Valéria Batista Lima, Adriana Rodrigues Barretto, Ismari Perini Furlaneto, Glenda Moraes Gonçalves, Ana Roberta Fusco da Costa, Maria Luiza Lopes, Margareth Pretti Dalcolmo

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Jornal brasileiro de pneumologia : publicacao oficial da Sociedade Brasileira de Pneumologia e Tisilogia, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 11 citations in OpenAlex.

  1. Challenges in the Diagnosis and Treatment of Mycobacterium abscessus Infections.Revista da Sociedade Brasileira de Medicina Tropical · 2026
    Review
  2. Mycobacterium abscessus subsp. bolletii keratitis: rare case reported in Brazil.Revista do Instituto de Medicina Tropical de Sao Paulo · 2020
    Article
  3. Review
  4. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

José Tadeu Colares MonteiroPrograma de Pós-Graduação em Biologia Parasitária na Amazônia, Centro Universitário do Estado do Pará, Universidade do Estado do Pará, Belém, PA, Brazil.
Karla Valéria Batista LimaLaboratório de Biologia Molecular, Seção de Bacteriologia e Micologia, Instituto Evandro Chagas, Ananindeua, PA, Brasil.
Adriana Rodrigues BarrettoFaculdade de Medicina, Universidade Federal do Pará, Belém, PA, Brazil.
Ismari Perini FurlanetoPrograma de Pós-Graduação em Biologia Parasitária na Amazônia, Centro Universitário do Estado do Pará, Universidade do Estado do Pará, Belém, PA, Brazil.
Glenda Moraes GonçalvesFaculdade de Medicina, Universidade Federal do Pará, Belém, PA, Brazil.
Ana Roberta Fusco da CostaLaboratório de Biologia Molecular, Seção de Bacteriologia e Micologia, Instituto Evandro Chagas, Ananindeua, PA, Brasil.
Maria Luiza LopesLaboratório de Biologia Molecular, Seção de Bacteriologia e Micologia, Instituto Evandro Chagas, Ananindeua, PA, Brasil.
Margareth Pretti DalcolmoPrograma de Pós-Graduação, Pontifícia Universidade Católica do Rio de Janeiro, Rio de Janeiro, RJ, Brazil.
Instituto Evandro Chagas · BRUniversidade do Estado do Pará · BRUniversidade Federal do Pará · BRPontifícia Universidade Católica do Rio de Janeiro · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo describe the clinical manifestations of patients with pulmonary infection caused by mycobacteria of the Mycobacterium abscessus complex (MABSC), and to compare these manifestations with those of patients infected with other nontuberculous mycobacteria (NTM).

methodsThis was a retrospective cohort study involving 43 patients divided into two groups: the MABSC group, consisting of patients with pulmonary infection caused by MABSC (n = 17); and the NTM group, consisting of patients with pulmonary infection caused by NTM other than MABSC (n = 26). Patients were previously treated with a regimen of rifampin, isoniazid, pyrazinamide, and ethambutol before the diagnosis of NTM was confirmed by two culture-positive sputum samples. The nucleotide sequences of the hsp65, 16S rRNA, and/or rpoB genes were analyzed to identify the mycobacteria. Data were collected on demographic, clinical, and radiological characteristics, as well as on treatment responses and outcomes.

resultsLoss of appetite was the only clinical manifestation that was significantly more common in the MABSC group than in the NTM group (p = 0.0306). The chance of having to use a second treatment regimen was almost 12 times higher in the MABSC group than in the NTM group. Treatment success was significantly higher in the NTM group than in the MABSC group (83.2% vs. 17.6%; p < 0.0001). The chance of recurrence was approximately 37 times higher in the MABSC group than in the NTM group.

conclusionsIn the study sample, treatment response of pulmonary disease caused by MABSC was less favorable than that of pulmonary disease caused by other NTM.

Indexed as

AdultAgedAged, 80 and overAntitubercular AgentsBrazilComorbidityFemaleHumansLife StyleLung DiseasesMaleMiddle AgedMycobacterium abscessusMycobacterium Infections, NontuberculousNontuberculous MycobacteriaRetrospective StudiesAntitubercular Agents

Identifiers

PMID29791556
PMCPMC6044653
OpenAlexW2795974808

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.