ArticlePLoS pathogens2018
A novel mouse model of Campylobacter jejuni enteropathy and diarrhea.
Article in PLoS pathogens, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
51 citing papers in PubMed, 64 citations in OpenAlex.
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- Time-Resolved Epithelial Responses to ETEC-K88 Reveal Tryptophan-Linked Protection in IPEC-J2 Cells and Strain-Specific Intestinal Injury in Mice.Animals : an open access journal from MDPI · 2026Article
- Zinc in Soil-Plant-Human Systems: A Synthesis of Its Fate, Essential Roles, and Health Implications.Scientifica · 2026Review
- A defined bacterial consortium and spatial transcriptomics highlight the complex interaction betweenGut microbes · 2025Article
- Review
- Treatment heterogeneity of water, sanitation, hygiene, and nutrition interventions on child growth by environmental enteric dysfunction and pathogen status for young children in Bangladesh.PLoS neglected tropical diseases · 2025Article
- Potential relationship between gut microbiota and animal diarrhea: a systematic review.Frontiers in microbiology · 2025Review
- Pathogenicity and virulence ofVirulence · 2024Review
- The epidemiology and impact of persistentEClinicalMedicine · 2024Article
- Possible Role of Cytomegalovirus in Gastric Cancer Development and Recurrent Macrolide-ResistantMicroorganisms · 2024Review
- Treatment Heterogeneity of Water, Sanitation, Hygiene, and Nutrition Interventions on Child Growth by Environmental Enteric Dysfunction and Pathogen Status for Young Children in Bangladesh.medRxiv : the preprint server for health sciences · 2024Article
- The Public Health Importance and Management of Infectious Poultry Diseases in Smallholder Systems in Africa.Foods (Basel, Switzerland) · 2024Review
- QcrC is a potential target for antibody therapy and vaccination to controlFrontiers in microbiology · 2024Article
- Protective effect of chicken yolk antibody Y againstFrontiers in microbiology · 2024Article
- Network analysis of patterns and relevance of enteric pathogen co-infections among infants in a diarrhea-endemic setting.PLoS computational biology · 2023Article
- Bacterial chemotaxis in human diseases.Trends in microbiology · 2023Review
- Environmental enteric dysfunction: gut and microbiota adaptation in pregnancy and infancy.Nature reviews. Gastroenterology & hepatology · 2023Review
- Molecular Targets inBiomolecules · 2023Review
- The Use of Interdisciplinary Approaches to Understand the Biology ofMicroorganisms · 2022Review
- Controlled Human Infection Models To Accelerate Vaccine Development.Clinical microbiology reviews · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 5 institutions in 4 countries.
Funding
Abstract
Campylobacter infections are among the leading bacterial causes of diarrhea and of 'environmental enteropathy' (EE) and growth failure worldwide. However, the lack of an inexpensive small animal model of enteric disease with Campylobacter has been a major limitation for understanding its pathogenesis, interventions or vaccine development. We describe a robust standard mouse model that can exhibit reproducible bloody diarrhea or growth failure, depending on the zinc or protein deficient diet and on antibiotic alteration of normal microbiota prior to infection. Zinc deficiency and the use of antibiotics create a niche for Campylobacter infection to establish by narrowing the metabolic flexibility of these mice for pathogen clearance and by promoting intestinal and systemic inflammation. Several biomarkers and intestinal pathology in this model also mimic those seen in human disease. This model provides a novel tool to test specific hypotheses regarding disease pathogenesis as well as vaccine development that is currently in progress.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.