Evidence map›Paper›PMID 29791486›Full record

ArticlePloS one2018

Involvement of the renin-angiotensin system in the progression of severe hand-foot-and-mouth disease.

Chao Zhang, Shuaiyin Chen, Guangyuan Zhou, Yuefei Jin, Rongguang Zhang, Haiyan Yang, Yuanlin Xi, Jingchao Ren, Guangcai Duan

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.9field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Chao ZhangDepartment of Epidemiology, College of Public Health, Zhengzhou University, Zhengzhou, Henan Province, China.
Shuaiyin ChenDepartment of Epidemiology, College of Public Health, Zhengzhou University, Zhengzhou, Henan Province, China.
Guangyuan ZhouDepartment of Epidemiology, School of Public Health, Xinxiang Medical University, Henan Province, Xinxiang, China.
Yuefei JinDepartment of Epidemiology, College of Public Health, Zhengzhou University, Zhengzhou, Henan Province, China.
Rongguang ZhangDepartment of Epidemiology, College of Public Health, Zhengzhou University, Zhengzhou, Henan Province, China.
Haiyan YangDepartment of Epidemiology, College of Public Health, Zhengzhou University, Zhengzhou, Henan Province, China.
Yuanlin XiDepartment of Epidemiology, College of Public Health, Zhengzhou University, Zhengzhou, Henan Province, China.
Jingchao RenDepartment of Epidemiology, School of Public Health, Xinxiang Medical University, Henan Province, Xinxiang, China.
Guangcai DuanDepartment of Epidemiology, College of Public Health, Zhengzhou University, Zhengzhou, Henan Province, China.ORCID 0000-0003-1353-9833
Zhengzhou University · CNXinxiang Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundHand-foot-and-mouth disease (HFMD) is generally considered as a mild exanthematous disease to infants and young children worldwide. HFMD cases are usually mild and self-limiting but for few cases leads to complicated severe clinical outcomes, and even death. Previous studies have indicated that serum Ang II levels in patients with H7N9 infection were related to the severity of infection. However, the mechanisms underlying the pathogenesis of severe HFMD remain unclear. This study was undertaken to clarify the role of the renin-angiotensin system (RAS) in the progression of severe HFMD.

methodsIn the present study, 162 children including HFMD patients and healthy controls were recruited. The data was analyzed by time-series fashion. Concentrations of angiotensin II (Ang II) and noradrenaline (NA) in serum of patients were measured with ELISA. We established a mouse model for enterovirus 71 (EV71) infection and determined concentrations of Ang II, NA in tissue lysates at 3, 5 and 7 days post infection (dpi).

resultsThe concentrations of Ang II and NA in serum of the HFMD patients with mild or severe symptoms were significantly higher than that in healthy controls. Additionally, the concentrations of Ang II and NA in serum of severe cases were significantly higher than those mild cases and the increased concentrations of Ang II and NA showed the same time trend during the progression of HFMD in the severe cases. Furthermore, the concentrations of Ang II and NA in target organs of EV71-infected mice including brains, skeletal muscle, and lungs were increased with the progression of EV71 infection in mice. Histopathological alterations were observed in the brains, skeletal muscle and lungs of EV71-infected mice.

conclusionOur study suggested that activation of the RAS is implicated in the pathogenesis of severe HFMD.

Indexed as

Disease ProgressionAngiotensin IIAnimalsChild, PreschoolEnterovirus A, HumanFemaleFoot-and-Mouth DiseaseHumansInfantMaleNorepinephrineRenin-Angiotensin SystemAngiotensin IINorepinephrine

Identifiers

PMID29791486
PMCPMC5965884
OpenAlexW3014520925

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.