ArticleJournal of perinatal medicine2018
Incidence of early-onset sepsis in infants born to women with clinical chorioamnionitis.
Article in Journal of perinatal medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 59 citations in OpenAlex.
- Association Between Endotype of Prematurity and Cystic Periventricular Leukomalacia: A Bayesian Model-Averaged Meta-Analysis.Children (Basel, Switzerland) · 2025Review
- Assessment of Culture-Negative Neonatal Early-Onset Sepsis: Risk Factors and Utility of Currently Used Serum Biomarkers.Children (Basel, Switzerland) · 2025Article
- Article
- Clinical chorioamnionitis at term: definition, pathogenesis, microbiology, diagnosis, and treatment.American journal of obstetrics and gynecology · 2024Review
- Wearable sensors for prediction of intraamniotic infection in women with preterm premature rupture of membranes: a prospective proof of principle study.Archives of gynecology and obstetrics · 2023Article
- Possible Rates of Detection of Neonatal Sepsis Pathogens in the Context of Microbiological Diagnostics in Mothers - Real World Data.Geburtshilfe und Frauenheilkunde · 2023Article
- The Role of Pancreatic Stone Protein (PSP) as a Biomarker of Pregnancy-Related Diseases.Journal of clinical medicine · 2023Article
- Epinephrine vs placebo in neonatal resuscitation: ROSC and brain MRS/MRI in term piglets.Pediatric research · 2023Article
- A retrospective study of risk factors for early-onset neonatal sepsis with intrapartum maternal fever.PeerJ · 2022Article
- Determinants for perinatal adverse outcomes among pregnant women with preterm premature rupture of membrane: A prospective cohort study.Frontiers in reproductive health · 2022Article
- The Distinct Immune Nature of the Fetal Inflammatory Response Syndrome Type I and Type II.ImmunoHorizons · 2021Article
- Neurodevelopmental Outcomes at 18-24 Months of Corrected Age in Very Low Birth Weight Infants with Late-onset Sepsis.Journal of Korean medical science · 2021Article
- A multicenter retrospective study on survival rate and complications of very preterm infants.Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2021Article
- RNA Sequencing Reveals Diverse Functions of Amniotic Fluid Neutrophils and Monocytes/Macrophages in Intra-Amniotic Infection.Journal of innate immunity · 2021Article
- Management of clinical chorioamnionitis: an evidence-based approach.American journal of obstetrics and gynecology · 2020Review
- Article
- Microbial burden and inflammasome activation in amniotic fluid of patients with preterm prelabor rupture of membranes.Journal of perinatal medicine · 2020Article
- Cellular immune responses in amniotic fluid of women with preterm clinical chorioamnionitis.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2020Article
- Neonatal and maternal outcomes of pregnancies with a fetal diagnosis of congenital heart disease using a standardized delivery room management protocol.Journal of perinatology : official journal of the California Perinatal Association · 2020Article
- Evidence that intra-amniotic infections are often the result of an ascending invasion - a molecular microbiological study.Journal of perinatal medicine · 2019Article
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Authors and funding
18 authors at 17 institutions in 1 country.
Funding
Abstract
Objective To determine the frequency of sepsis and other adverse neonatal outcomes in women with a clinical diagnosis of chorioamnionitis. Methods We performed a secondary analysis of a multi-center placebo-controlled trial of vitamins C/E to prevent preeclampsia in low risk nulliparous women. Clinical chorioamnionitis was defined as either the "clinical diagnosis" of chorioamnionitis or antibiotic administration during labor because of an elevated temperature or uterine tenderness in the absence of another cause. Early-onset neonatal sepsis was categorized as "suspected" or "confirmed" based on a clinical diagnosis with negative or positive blood, urine or cerebral spinal fluid cultures, respectively, within 72 h of birth. Adjusted odds ratios (ORs) and 95% confidence intervals (CIs) were estimated by logistic regression. Results Data from 9391 mother-infant pairs were analyzed. The frequency of chorioamnionitis was 10.3%. Overall, 6.6% of the neonates were diagnosed with confirmed (0.2%) or suspected (6.4%) early-onset sepsis. Only 0.7% of infants born in the setting of chorioamnionitis had culture-proven early-onset sepsis versus 0.1% if chorioamnionitis was not present. Clinical chorioamnionitis was associated with both suspected [OR 4.01 (3.16-5.08)] and confirmed [OR 4.93 (1.65-14.74)] early-onset neonatal sepsis, a need for resuscitation within the first 30 min after birth [OR 2.10 (1.70-2.61)], respiratory distress [OR 3.14 (2.16-4.56)], 1 min Apgar score of ≤3 [OR 2.69 (2.01-3.60)] and 4-7 [OR 1.71 (1.43-2.04)] and 5 min Apgar score of 4-7 [OR 1.67 (1.17-2.37)] (vs. 8-10). Conclusion Clinical chorioamnionitis is common and is associated with neonatal morbidities. However, the vast majority of exposed infants (99.3%) do not have confirmed early-onset sepsis.
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