ArticleJournal of cognitive neuroscience2018
The Influence of Dopamine on Cognitive Flexibility Is Mediated by Functional Connectivity in Young but Not Older Adults.
Article in Journal of cognitive neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 3 syntheses or guidelines pooled it, 35 citations in OpenAlex.
- Population-Level Age Effects on the White Matter Structure Subserving Cognitive Flexibility in the Human Brain.eNeuro · 2026Pooled it
- A meta-analysis of cognitive flexibility in aging: Perspective from functional network and lateralization.Human brain mapping · 2024Pooled it
- The effect of age on task switching: updated and extended meta-analyses.Psychological research · 2023Pooled it
- Integrating computational modeling, neuroimaging, and neuromodulation to decompose perceptual decision-making in healthy aging: a review of methods, findings, and gaps.Frontiers in aging neuroscience · 2026Review
- Physical activity and neuroplasticity in neurodegenerative disorders: a comprehensive review of exercise interventions, cognitive training, and AI applications.Frontiers in neuroscience · 2025Review
- Pathological and neurochemical correlates of locus coeruleus functional network activity.Biological psychology · 2024Article
- Resting state network connectivity is associated with cognitive flexibility performance in youth in the Adolescent Brain Cognitive Development Study.Neuropsychologia · 2023Article
- Poorer aging trajectories are associated with elevated serotonin synthesis capacity.Molecular psychiatry · 2023Article
- Striatal dopamine synthesis and cognitive flexibility differ between hormonal contraceptive users and nonusers.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Longitudinal effects of choir singing on aging cognition and wellbeing: a two-year follow-up study.Frontiers in human neuroscience · 2023Article
- Interactive effects of locus coeruleus structure and catecholamine synthesis capacity on cognitive function.Frontiers in aging neuroscience · 2023Article
- Elevated Dopamine Synthesis as a Mechanism of Cognitive Resilience in Aging.Cerebral cortex (New York, N.Y. : 1991) · 2022Article
- Advances in simultaneous PET/MR for imaging neuroreceptor function.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2020Review
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- Age-Related Differences in Motivational Integration and Cognitive Control.Cognitive, affective & behavioral neuroscience · 2019Article
- Age-related variability in decision-making: Insights from neurochemistry.Cognitive, affective & behavioral neuroscience · 2019Review
- Dopaminergic Mechanisms Underlying Normal Variation in Trait Anxiety.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Dysfunction between dorsal caudate and salience network associated with impaired cognitive flexibility in obsessive-compulsive disorder: A resting-state fMRI study.NeuroImage. Clinical · 2019Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Dopaminergic signaling in striatum is strongly implicated in executive functions including cognitive flexibility. However, there is a paucity of multimodal research in humans defining the nature of relationships between endogenous dopamine, striatal network activity, and cognition. Here, we measured dopamine synthesis capacity in young and older adults using the PET tracer 6-[
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.