Evidence map›Paper›PMID 29791184›Full record

ReviewChildhood obesity (Print)2018

A Narrative Review of Medical and Genetic Risk Factors among Children Age 5 and Younger with Severe Obesity.

Nazrat Mirza, Thao-Ly Phan, June Tester, Angela Fals, Cristina Fernandez, George Datto, Elizabeth Estrada, Ihuoma Eneli

Open access · greenAbstract readReview
In one paragraph

Review in Childhood obesity (Print), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.

  1. New Perspectives in Modulating the Entero-Insular Axis in Pediatric Obesity.International journal of molecular sciences · 2025
    Pooled it
  2. Article
  3. Article
  4. Article
  5. Pediatric Obesity Treatment: Considerations for Diabetes Educators and Clinicians.Diabetes spectrum : a publication of the American Diabetes Association · 2024
    Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 7 institutions in 1 country.

Nazrat Mirza1 Department of Pediatrics and Adolescent Medicine, Children's National Health System, and George Washington University , Washington, DC.
Thao-Ly Phan2 Department of Pediatrics, Sidney Kimmel Medical College at Thomas Jefferson University , Philadelphia, PA.
June Tester4 Division of Endocrinology, UCSF Benioff Children's Hospital Oakland , Oakland, CA.
Angela Fals5 Center for Child and Family Wellness, Florida Hospital for Children , Orlando, FL.
Cristina Fernandez6 Creighton University and Children's Hospital and Medical Center , Omaha, NE.
George Datto2 Department of Pediatrics, Sidney Kimmel Medical College at Thomas Jefferson University , Philadelphia, PA.
Elizabeth Estrada7 Pediatric Endocrinology, University of North Carolina , Chapel Hill, NC.
Ihuoma Eneli8 Center for Healthy Weight and Nutrition, Nationwide Children's Hospital, and Ohio State University , Columbus, OH.
Thomas Jefferson University · USAdventHealth for Children · USChildren's Hospital & Medical Center · USChildren's National · USNationwide Children's Hospital · USUCSF Benioff Children's Hospital · USUniversity of North Carolina at Chapel Hill · US

Funding

WirelessTechnology Assisted Weight Management in Pre-Diabetic Adolescents...P20MD000198 · NIMHD · HOWARD UNIVERSITY · PI JENKINS, RENEE R. · 2002 to 2016
$17.2M
Integrating Parenting Interventions into Pediatric Obesity CareK23HD083439 · NICHD · NEMOURS CHILDREN'S HOSPITAL, DELAWARE · PI PHAN-VO, THAO-LY TAM · 2016 to 2020
$776k
The impact of concurrent food insecurity and obesity in childrenK23HD075852 · NICHD · CHILDREN'S HOSPITAL & RES CTR AT OAKLAND · PI TESTER, JUNE M · 2014 to 2018
$756k
NICHD NIH HHS K23 HD075852NICHD NIH HHS K23 HD083439NIMHD NIH HHS P20 MD000198
6 · The paper itself

Abstract

Severe obesity defined as an age- and gender-specific body mass index ≥120% of the 95th percentile in children younger than 5 years is well recognized as a significant challenge for prevention and treatment. This article provides an overview of the prevalence, classification of obesity severity, patterns of weight gain trajectory, medical and genetic risk factors, and comorbid disorders among young children with an emphasis on severe obesity. Studies suggest rapid weight gain trajectory in infancy, maternal smoking, maternal gestational diabetes, and genetic conditions are associated with an increased risk for severe obesity in early childhood. Among populations of young children with severe obesity seeking care, co-morbid conditions such as dyslipidemia and fatty liver disease are present and families report behavioral concerns and developmental delays. Children with severe obesity by age 5 represent a vulnerable population of children at high medical risk and need to be identified early and appropriately managed.

Indexed as

Genetic Predisposition to DiseaseBody Mass IndexChild, PreschoolComorbidityDiabetes, GestationalDyslipidemiasEthnicityFemaleHumansInfantInsulin ResistanceMaleMaternal BehaviorNon-alcoholic Fatty Liver DiseaseObesity, MorbidPediatric Obesitygeneticsmedical complicationsrisk factorssevere obesityyoung children

Identifiers

PMID29791184
PMCPMC6157342
OpenAlexW2804567010

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.