ArticleBrain and behavior2018
Alterations of brain network hubs in reflex syncope: Evidence from a graph theoretical analysis based on DTI.
Article in Brain and behavior, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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4 citing papers in PubMed.
- Article
- Application of machine learning analysis based on diffusion tensor imaging to identify REM sleep behavior disorder.Sleep & breathing = Schlaf & Atmung · 2022Article
- Network differences based on arterial spin labeling related to anti-seizure medication response in focal epilepsy.Neuroradiology · 2022Article
- Alterations of brain network hubs in reflex syncope: Evidence from a graph theoretical analysis based on DTI.Brain and behavior · 2018Article
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7 authors.
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Abstract
objectiveWe evaluated global topology and organization of regional hubs in the brain networks and microstructural abnormalities in the white matter of patients with reflex syncope.
methodsTwenty patients with reflex syncope and thirty healthy subjects were recruited, and they underwent diffusion tensor imaging (DTI) scans. Graph theory was applied to obtain network measures based on extracted DTI data, using DSI Studio. We then investigated differences in the network measures between the patients with reflex syncope and the healthy subjects. We also analyzed microstructural abnormalities of white matter using tract-based spatial statistics analysis (TBSS).
resultsMeasures of global topology were not different between patients with reflex syncope and healthy subjects. However, in reflex syncope patients, the strength measures of the right angular, left inferior frontal, left middle orbitofrontal, left superior medial frontal, and left middle temporal gyrus were lower than in healthy subjects. The betweenness centrality measures of the left middle orbitofrontal, left fusiform, and left lingual gyrus in patients were lower than those in healthy subjects. The PageRank centrality measures of the right angular, left middle orbitofrontal, and left superior medial frontal gyrus in patients were lower than those in healthy subjects. Regarding the analysis of the white matter microstructure, there were no differences in the fractional anisotropy and mean diffusivity values between the two groups.
conclusionsWe have identified a reorganization of network hubs in the brain network of patients with reflex syncope. These alterations in brain network may play a role in the pathophysiologic mechanism underlying reflex syncope.
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