Evidence map›Paper›PMID 29791073›Full record

ArticleJournal of diabetes investigation2019

Elevated histone H3 acetylation is associated with genes involved in T lymphocyte activation and glutamate decarboxylase antibody production in patients with type 1 diabetes.

Yanfei Wang, Can Hou, Jonathan Wisler, Kanhaiya Singh, Chao Wu, Zhiguo Xie, Qianjin Lu, Zhiguang Zhou

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of diabetes investigation, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.3field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 21 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Post-translational modifications in the Protein Data Bank.Acta crystallographica. Section D, Structural biology · 2024
    Review
  5. Review
  6. Epigenetic basis of diabetic vasculopathy.Frontiers in endocrinology · 2022
    Review
  7. Article
  8. Review
  9. Article
  10. Review
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 3 countries.

Yanfei WangDepartment of Metabolism & Endocrinology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.ORCID http://orcid.org/0000-0001-6390-6318
Can HouDepartment of Intensive Care Unit, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
Jonathan WislerDepartment of Surgery, Division of Trauma, Critical Care and Burn Surgery, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA.
Kanhaiya SinghDepartment of Surgery, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA.
Chao WuDepartment of Metabolism & Endocrinology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
Zhiguo XieDepartment of Metabolism & Endocrinology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
Qianjin LuDepartment of Dermatology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
Zhiguang ZhouDepartment of Metabolism & Endocrinology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.ORCID http://orcid.org/0000-0002-0374-1838
Central South University · CNThe Ohio State University Wexner Medical Center · US

Funding

China Scholarship Council 201606375127Fundamental Research Funds for the Central Universities of Central South University 502221703Hunan Provincial Natural Science Foundation of China 14JJ3042Key Project of Chinese Ministry of Education 113050ANational Natural Science Foundation of China 81200580National Natural Science Foundation of China 81461168031National Science and Technology Infrastructure Program 2015BAI12B13the Doctoral Fund of Ministry of Education of China 20120162120090
6 · The paper itself

Abstract

AIMS/

introductionGenetic and epigenetic mechanisms have been implicated in the pathogenesis of type 1 diabetes, and histone acetylation is an epigenetic modification pattern that activates gene transcription. However, the genome-wide histone H3 acetylation in new-onset type 1 diabetes patients has not been well described. Accordingly, we aimed to unveil the genome-wide promoter acetylation profile in CD4 MATERIALS AND

methodsA total of 12 patients with new-onset type 1 diabetes who were glutamate decarboxylase antibody-positive were enrolled, and 12 healthy individuals were recruited as controls. The global histone H3 acetylation level of CD4

resultsElevated global histone H3 acetylation level was observed in type 1 diabetes patients, with 607 differentially acetylated genes identified between type 1 diabetes patients and controls by chromatin immunoprecipitation linked to microarrays. The hyperacetylated genes were enriched in biological processes involved in immune cell activation and inflammatory response. Gene-specific assessments showed that increased transcription of inducible T-cell costimulator was in concordance with the elevated acetylation in its gene promoter, along with positive correlation with glutamate decarboxylase antibody titer in type 1 diabetes patients.

conclusionsThe present study generates a genome-wide histone acetylation profile specific to CD4

Indexed as

Lymphocyte ActivationAcetylationAdultAntibodiesCD4-Positive T-LymphocytesDiabetes Mellitus, Type 1Epigenesis, GeneticFemaleGlutamate DecarboxylaseHistonesHumansMaleAntibodiesGlutamate DecarboxylaseHistonesCD4+ T lymphocytesHistone H3 acetylation profileType 1 diabetes

Identifiers

PMID29791073
PMCPMC6319479
OpenAlexW2804473699

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.