SynthesisPaediatrics and international child health2018
Antibiotic use for community-acquired pneumonia in neonates and children: WHO evidence review.
Synthesis in Paediatrics and international child health, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
41 citing papers in PubMed, 2 syntheses or guidelines pooled it, 129 citations in OpenAlex.
- Antimicrobial resistance in paediatricThe Lancet. Microbe · 2021Pooled it
- Antibiotic therapy versus no antibiotic therapy for children aged 2 to 59 months with WHO-defined non-severe pneumonia and wheeze.The Cochrane database of systematic reviews · 2021Pooled it
- Diagnostic value of cytokine detection in children with Mycoplasma pneumoniae pneumonia complicated by bacterial or viral co-infections.BMC pediatrics · 2026Article
- Risk Factors for Antibiotic-Associated Diarrhoea in Paediatric Patients With Severe Pneumonia: A Retrospective Cohort.Nursing in critical care · 2026Article
- The hidden cost of antibiotics: microbial dysbiosis-induced SCFA imbalance and its underlying mechanisms.Frontiers in immunology · 2026Review
- Handling multiple time-varying exposures in survival analysis using real-world pediatric data from the pedianet database.Scientific reports · 2025Article
- Effects of community-acquired pneumonia on biventricular cardiac functions in children.Italian journal of pediatrics · 2025Article
- Factors associated with neonatal sepsis among neonates admitted in Kibungo Referral Hospital, Rwanda.Scientific reports · 2024Article
- Clinical Efficacy of Azithromycin in the Treatment of PediatricInfection and drug resistance · 2024Article
- Altered hepatic and intestinal homeostasis in a neonatal murine model of short-term total parenteral nutrition and antibiotics.American journal of physiology. Gastrointestinal and liver physiology · 2023Article
- Development over time in point-of-care test use in Danish daytime and out-of-hours general practice: a register-based study.Scandinavian journal of primary health care · 2023Article
- Predicting the causative pathogen among children with pneumonia using a causal Bayesian network.PLoS computational biology · 2023Article
- Indoor bacterial and fungal aerosols as predictors of lower respiratory tract infections among under-five children in Ibadan, Nigeria.BMC pulmonary medicine · 2022Article
- Qiangli Wuhu mixture alleviates LPS-induced pneumonia by inhibiting the TLR4/NF-κB/NLRP3 pathway: a study based on network pharmacology.Pharmaceutical biology · 2022Article
- Epidemiology of community-acquired pneumonia among hospitalised children in Indonesia: a multicentre, prospective study.BMJ open · 2022Article
- A prospective observational study of community-acquired bacterial bloodstream infections in Metro Manila, the Philippines.PLoS neglected tropical diseases · 2022Observational
- Double-signal quantification of amoxicillin based on interaction with 4-aminoantipyrine at copper and nitrogen co-doped carbon quantum dots as an artificial nanozyme.Mikrochimica acta · 2022Article
- Article
- Antibiotic Use and Outcomes in Young Children Hospitalized With Uncomplicated Community-Acquired Pneumonia.Open forum infectious diseases · 2022Article
- Auxiliary Pneumonia Classification Algorithm Based on Pruning Compression.Computational and mathematical methods in medicine · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background Pneumonia is the most common cause of death in children worldwide, accounting for 15% of all deaths of children under 5 years of age. This review summarises the evidence for the empirical antibiotic treatment of community-acquired pneumonia in neonates and children and puts emphasis on publications since the release of the previous WHO Evidence Summary report published in 2014. Methods A systematic search for systematic reviews and meta-analyses of antibiotic therapy for community-acquired pneumonia was conducted between 1 January 2013 and 10 November 2016. Results The optimal dosing recommendation for amoxicillin remains unclear with limited pharmacological and clinical evidence. There is limited evidence from surveillance to indicate whether amoxicillin or broader spectrum antibiotics (e.g. third-generation cephalosporins) are being used most commonly for paediatric CAP in different WHO regions. Data are lacking on clinical efficacy in the context of pneumococcal, staphylococcal and mycoplasma disease and the relative contributions of varying first-line and step-down options to the selection of such resistance. Conclusion Further pragmatic trials are required to optimise management of hospitalised children with severe and very severe pneumonia.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.