Evidence map›Paper›PMID 29790737›Full record

ArticleAnalytical chemistry2018

Environmental Stability of Plasmonic Biosensors Based on Natural versus Artificial Antibody.

Jingyi Luan, Ting Xu, John Cashin, Jeremiah J Morrissey, Evan D Kharasch, Srikanth Singamaneni

Open access · greenAbstract readComparative Study
In one paragraph

Article in Analytical chemistry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.8field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 36 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. β-BiNanomaterials (Basel, Switzerland) · 2023
    Article
  5. Article
  6. Review
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Jingyi LuanInstitute of Materials Science and Engineering, Department of Mechanical Engineering and Materials Science , Washington University in St. Louis , St. Louis , Missouri 63130 , United States.
Ting XuInstitute of Materials Science and Engineering, Department of Mechanical Engineering and Materials Science , Washington University in St. Louis , St. Louis , Missouri 63130 , United States.
John CashinInstitute of Materials Science and Engineering, Department of Mechanical Engineering and Materials Science , Washington University in St. Louis , St. Louis , Missouri 63130 , United States.
Jeremiah J MorrisseyORCID 0000-0002-9911-4811
Evan D KharaschThe Center for Clinical Pharmacology , St. Louis College of Pharmacy and Washington University School of Medicine , St. Louis , Missouri 63110 , United States.
Srikanth SingamaneniInstitute of Materials Science and Engineering, Department of Mechanical Engineering and Materials Science , Washington University in St. Louis , St. Louis , Missouri 63130 , United States.ORCID 0000-0002-7203-2613
Washington University in St. Louis · USUniversity of Health Sciences and Pharmacy · US

Funding

URINARY BIOMARKERS OF RENAL CELL CARCINOMASR01CA141521 · NCI · WASHINGTON UNIVERSITY · PI MORRISSEY, JEREMIAH J · 2011 to 2019
$2.6M
POINT OF CARE ACUTE KIDNEY INJURY DETECTION USING MOLECULARLY IMPRINTED GOLD NANOCAGESR21DK100759 · NIDDK · WASHINGTON UNIVERSITY · PI SINGAMANENI, SRIKANTH · 2015 to 2016
$411k
The Role of Bone Morphogenetic Protein-7 in Renal Endothelial Cell BiologyR21DK076000 · NIDDK · WASHINGTON UNIVERSITY · PI MORRISSEY, JEREMIAH J · 2007 to 2008
$376k
NCI NIH HHS R01 CA141521NIDDK NIH HHS R21 DK076000NIDDK NIH HHS R21 DK100759
6 · The paper itself

Abstract

Plasmonic biosensors based on the refractive index sensitivity of localized surface plasmon resonance (LSPR) are considered to be highly promising for on-chip and point-of-care biodiagnostics. However, most of the current plasmonic biosensors employ natural antibodies as biorecognition elements, which can easily lose their biorecognition ability upon exposure to environmental stressors (e.g., temperature and humidity). Plasmonic biosensors relying on molecular imprints as recognition elements (artificial antibodies) are hypothesized to be an attractive alternative for applications in resource-limited settings due to their excellent thermal, chemical, and environmental stability. In this work, we provide a comprehensive comparison of the stability of plasmonic biosensors based on natural and artificial antibodies. Although the natural antibody-based plasmonic biosensors exhibit superior sensitivity, their stability (temporal, thermal, and chemical) was found to be vastly inferior to those based on artificial antibodies. Our results convincingly demonstrate that these novel classes of artificial antibody-based plasmonic biosensors are highly attractive for point-of-care and resource-limited conditions where tight control over transport, storage, and handling conditions is not possible.

Indexed as

AdsorptionAntibodiesBiomimetic MaterialsGoldMolecular ImprintingPolymersProtein StabilitySurface Plasmon ResonanceAntibodiesGoldPolymers

Identifiers

PMID29790737
PMCPMC6481193
OpenAlexW2803353343

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.